Qualidade das águas e uso e cobertura da terra: subsídios para a gestão de recursos hídricos da bacia hidrográfica do rio Pindaré, Maranhão – Brasil

 This study will discuss surface water quality through an analysis of the Pindaré river basin, located in the Amazon region of Maranhão. To this end, water quality data was assessed at 13 collection points and correlated with land use. The water showed acceptable conditions in the parameters measured, with the exception of some points which showed high turbidity, considerable conductivity and a decrease in dissolved oxygen in areas located adjacent to urban centers, where there is an increase in the dumping of solid waste and in natura sewage into the spring. This research proposes discussions for improving and/or maintaining water quality, identifying the main uses in the face of primary and secondary contact with the population.En este estudio se abordará la calidad de las aguas superficiales mediante el análisis de la cuenca del río Pindaré, situado en la región amazónica de Maranhão. Para ello, se analizaron los datos de calidad del agua en 13 puntos de captación y se correlacionaron con el uso del suelo. El agua presentó condiciones aceptables en los parámetros medidos, con excepción de algunos puntos que presentaron turbidez elevada, conductividad considerable y disminución del oxígeno disuelto en las áreas adyacentes a los centros urbanos, donde hay un aumento del vertido de residuos sólidos y de aguas residuales naturales en el manantial. Esta investigación propone discusiones para mejorar y/o mantener la calidad del agua, identificando los principales usos frente al contacto primario y secundario con la población.Cette étude aborde la qualité des eaux de surface en analysant le bassin du fleuve Pindaré, situé dans la région amazonienne du Maranhão. À cette fin, les données relatives à la qualité de l'eau ont été analysées en 13 points de collecte et mises en corrélation avec l'utilisation des terres. L'eau a montré des conditions acceptables pour les paramètres mesurés, à l'exception de certains points qui ont montré une turbidité élevée, une conductivité considérable et une diminution de l'oxygène dissous dans les zones situées à proximité des centres urbains, où il y a une augmentation du déversement des déchets solides et des eaux usées in natura dans la source. Cette recherche propose des discussions pour améliorer et/ou maintenir la qualité de l'eau, en identifiant les principaux usages face au contact primaire et secondaire avec la population.Questo studio tratterà la qualità delle acque superficiali analizzando nel bacino del fiume Pindaré, situato nella regione amazzonica del Maranhão. A tal fine, sono stati analizzati i dati sulla qualità dell'acqua in 13 punti di raccolta e sono stati messi in relazione con l'uso del suolo. L'acqua ha mostrato condizioni accettabili nei parametri misurati, ad eccezione di alcuni punti che hanno mostrato un'elevata torbidità, una notevole conducibilità e una diminuzione dell'ossigeno disciolto nelle aree adiacenti ai centri urbani, dove si registra un aumento dello scarico di rifiuti solidi e di acque reflue naturali nella sorgente. Questa ricerca propone discussioni per migliorare e/o mantenere la qualità dell'acqua, identificando gli usi principali a fronte del contatto primario e secondario con la popolazione.No presente estudo serão suscitadas discussões voltadas à qualidade das águas superficiais, através de uma análise da bacia hidrográfica do rio Pindaré, localizada na Amazônia maranhense. Para tanto, foram avaliados dados de qualidade de água ao longo de 13 pontos de coleta e sua correlação ao uso da terra. As águas apresentaram condições aceitáveis nos parâmetros aferidos, com exceção de alguns pontos que mostraram alta turbidez, considerável condutividade e diminuição do oxigênio dissolvido em áreas localizadas contíguas a centros urbanos, nas quais há um aumento no despejo de resíduos sólidos e esgotos in natura lançados no manancial. Nesta investigação são propostas discussões para melhoria e/ou manutenção da qualidade das águas, identificando os principais usos diante do contato primário e secundário com a população

GOVERNANÇA CORPORATIVA EM UMA EMPRESA FAMILIAR DE PERNAMBUCO

Este artigo descreve um estudo sobre a implementação da Governança Corporativa numa empresa familiar de capital fechado do estado de PE. O estudo evidencia os motivos que levaram à sua implantação, os benefícios advindos e os aspectos institucionais que foram estimulados pela Governança, utilizando para isso coleta de informações subsidiada com informações constantes no próprio site da empresa e aplicação de questionário, o qual foi respondido pela Gerência de Governança da empresa. A base teórica é composta principalmente de publicações realizadas pelo Instituto Brasileiro de Governança Corporativa (IBGC), artigos e dissertações. O estudo permite concluir que a Governança Corporativa foi difundida e solidificou-se na organização objetivando garantir a sucessão e a perpetuação da organização de forma sustentável, contribuindo para sua longevidade através da disseminação do planejamento estratégico sem perder os valores da família. Observa-se ainda entre os aspectos institucionais estimulados pela Governança as mudanças na cultura da organização, a criação de um conselho de administração e do conselho de família

Distribuicao de dermatofitos isolados de solos de cidades do Estado da Paraiba, Brasil

SUMMARY The dermatophytes, keratinophilic fungi, represent important microorganisms of the soil microbiota, where there are cosmopolitan species and others with restricted geographic distribution. The aim of this study was to broaden the knowledge about the presence of dermatophytes in soils of urban (empty lots, schools, slums, squares, beaches and homes) and rural areas and about the evolution of their prevalence in soils of varying pH in cities of the four mesoregions of Paraiba State, Brazil. Soil samples were collected from 31 cities of Paraiba State. Of 212 samples, 62% showed fungal growth, particularly those from the Mata Paraibana mesoregion (43.5%), which has a tropical climate, hot and humid. Soil pH varied from 4.65 to 9.06, with 71% of the growth of dermatophytes occurring at alkaline pH (7.02 - 9.06) (ρ = 0.000). Of 131 strains isolated, 57.3% were geophilic species, particularly Trichophyton terrestre (31.3%) and Mycrosporum gypseum (21.4%). M. nanum and T. ajelloi were isolated for the first time in Paraiba State. The zoophilic species identified were T. mentagrophytes var. mentagrophytes (31.3 %) and T. verrucosum (7.6 %), and T. tonsurans was isolated as an anthropophilic species. The soils of urban areas including empty lots, schools, slums and squares of cities in the mesoregions of Paraiba State were found to be the most suitable reservoirs for almost all dermatophytes; their growth may have been influenced by environmental factors, soils with residues of human and/or animal keratin and alkaline pH.RESUMO Os dermatófitos, fungos queratinofílicos, representam importantes microrganismos da microbiota do solo, onde existem espécies cosmopolitas e outras de distribuição geográfica restrita. Este estudo teve como objetivo ampliar o conhecimento da distribuição de dermatófitos do solo proveniente de áreas urbanas (terrenos baldios, escolas, favelas, praças, praias e residências) e rurais de quatro mesorregiões paraibanas e da influência do pH na adaptação desse grupo de fungos. Amostras de solos urbanos e rurais foram coletadas de 31 cidades do estado da Paraíba, Brasil. De 212 amostras 62% apresentaram crescimento fúngico, destacando-se a Mesorregião da Mata Paraibana (43.5%), a qual apresenta clima tropical, quente e úmido. O pH das amostras de solo variou de 4.65 a 9.06, com crescimento de 71% dos dermatófitos em pH alcalino (7.02 - 9.06) (ρ = 0.000). Das 131 cepas isoladas 57.3% eram espécies geofílicas, destacando-se Trichophyton terrestre (31.3%) e Microsporum gypseum (21.4%). M. nanum e T. ajelloi foram isolados pela primeira vez no estado da Paraíba. Entre as espécies zoofílicas foram identificadas T. mentagrophytes var. mentagrophytes (31.3%) e T. verrucosum (7.6%) e como espécie antropofílica foi isolada T. tonsurans. Os solos de terrenos baldios, escolas, favelas e praças de cidades paraibanas são os reservatórios mais adequados dos dermatófitos, cujo crescimento pode ter sido influenciado por fatores ambientais, solos com resíduos de queratina humana e ou animal e pH alcalino

A structure-based site-directed mutagenesis study on the neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) catalysis

Neurolysin (EP24.16) and thimet oligopeptidase (EP24.15) are closely related metalloendopeptidases. Site-directed mutagenesis of Tyr(613) (EP24.16) or Tyr(612) (EP24.15) to either Phe or Ala promoted a strong reduction of k(cat)/K-M for both enzymes. These data suggest the importance of both hydroxyl group and aromatic ring at this specific position during substrate hydrolysis by these peptidases. Furthermore, the EP24.15 A607G mutant showed a k(cat)/K-M of 2x10(5) M-1 s(-1) for the Abz-GFSIFRQ-EDDnp substrate, similar to that of EP24.16 (k(cat)/K-M = 3x10(5) M-1 s(-1)) which contains Gly at the corresponding position; the wild type EP24.15 has a k(cat)/K-M of 2.5x10(4) M-1 s(-1) for this substrate. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.Univ Mogi das Cruzes, CIIB, BR-08780911 Mogi Das Cruzes, SP, BrazilInst Butantan, CAT, Ctr Toxicol Aplicada, BR-05467010 São Paulo, BrazilUniv São Paulo, Inst Ciencias Biomed, Program Biol Celular, Dept Histol & Embriol, BR-05508900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biofis, BR-04044020 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biofis, BR-04044020 São Paulo, BrazilWeb of Scienc

Economic feasibility of diets containing different nitrogen sources as a function of weight gain in Saanen breed goats / Viabilidade Econômica de dietas contendo diferentes fontes de nitrogênio em função do ganho de peso de caprinos da raça Saanen

The use of a low cost protein input results in improvements in animal zootechnical indices. The aim of this study was to evaluate the cost of diets containing different nitrogen sources as a function of weight gain in Saanen goats. Eighteen 150-day-old Saanen goats were randomly divided into two groups: control group (CG) and urea group (UG). At the beginning of the experiment and every 7 days, before feeding, the animals were weighed on a mechanical platform scale to obtain live weight over a period of 121 days. The prices of the dietary ingredients were obtained from the local market of Seropédica - RJ, from April to June 2019. For statistical analysis, the GraphPad PRISM 5® software was used. The use of soybean meal or urea in the diet did not influence animal performance in relation to daily weight gain. The difference in values may not appear to be attractive, but the amount of urea used in ruminant diets is much smaller when compared to the amount of soybean meal, which reflects in the final diet price, making urea make a source more viable for the producer

The role of veracity on the load monitoring of professional soccer players: a systematic review in the face of the big data era

Big Data has real value when the veracity of the collected data has been previously identified. However, data veracity for load monitoring in professional soccer players has not been analyzed yet. This systematic review aims to evaluate the current evidence from the scientific literature related to data veracity for load monitoring in professional soccer. Systematic searches through the PubMed, Scopus, and Web of Science databases were conducted for reports onthe data veracity of diverse load monitoring tools and the associated parameters used in professional soccer. Ninety-four studies were finally included in the review, with 39 different tools used and 578 associated parameters identified. The pooled sample consisted of 2066 footballers (95% male: 24 ± 3 years and 5% female: 24 ± 1 years). Seventy-three percent of these studies did not report veracity metrics for anyof the parameters from these tools. Thus, data veracity was found for 54% of tools and 23% of parameters. The current information will assist in the selection of the most appropriate tools and parameters to be used for load monitoring with traditional and Big Data approaches while identifying those still requiring the analysis of their veracity metrics or their improvement to acceptable veracity levels

Fluoxetine: indication of inadequate use

OBJECTIVE: Investigate the use of fluoxetine in Santo André city, SP, by collecting and analyzing special prescriptions (SP) issued by physicians and filed in compounding pharmacies and drugstores of that city. METHODS: Special prescriptions were collected during August 2005 to July 2006 in 13 compounding pharmacies and 27 drugstores, in different regions of Santo André. Each prescription has been examined for the presence of fluoxetine, in combination or not with other active ingredients, and sex (a) patient was noted. RESULTS: We examined 39,782 SP; 16,124 of them were collected from compounding pharmacies and 23,658 from drugstores. Of these totals, 10,919 prescriptions contained fluoxetine as follows: 9,259 from the compounding pharmacies (84.8%) and only 1,660 (15.2%) from drugstores. Fluoxetine was manly prescribed for women (79.8%). In the vast majority of SP, fluoxetine was prescribed in combination with a large number of other active substances reaching more than ten others in almost half of the prescriptions. CONCLUSION: It is suggested that the large use of fluoxetine possibily aims to an aesthetic objective (to lose weight) and not as a therapeutic aim (treatment of depression). This work discusses the risk/benefit of this use which could be described as inappropriate, given the known adverse reactions of fluoxetine and its interference with the cytochrome P450 system.OBJETIVO: Investigar o uso da fluoxetina na cidade de Santo André, SP, por meio de coleta e análise das receitas especiais (RE) prescritas por médicos e arquivadas nas farmácias e drogarias daquela cidade. MÉTODOS: Foram coletadas as receitas especiais retidas durante os meses de agosto do ano de 2005 a julho de 2006, em 13 farmácias de manipulação e em 27 drogarias em diferentes regiões de Santo André. Cada receita especial foi analisada em relação à presença de fluoxetina, em associação ou não a outros princípios ativos, e o sexo do(a) paciente foi anotado. RESULTADOS: Foram analisadas 39.782 RE - 16.124 coletadas das farmácias magistrais e 23.658 das drogarias. Desses totais, 10.919 prescrições continham fluoxetina - 9.259 provenientes das farmácias magistrais (84,8%) e apenas 1.660 (15,2%) das drogarias. As prescrições de fluoxetina eram predominantemente destinadas a mulheres (79,8%). Na imensa maioria das RE, a fluoxetina foi prescrita em associação com um grande número de outras substâncias ativas, inclusive anfetaminas anoréticas, chegando a mais de dez outras em quase a metade das prescrições. Esse tipo de prescrição múltipla, principalmente para mulheres, é comparado com as prescrições de fórmulas magistrais para emagrecer, muito utilizadas no Brasil. CONCLUSÃO: Os dados obtidos sugerem que a utilização de fluoxetina teria um fim estético (perda de peso), e não um fim terapêutico (tratamento de depressão). Discute-se a relação risco-benefício desse possível uso, que poderia ser classificado de inadequado dado as conhecidas reações adversas da fluoxetina e a sua interferência no sistema citocromo P450.Universidade Federal de São Paulo (UNIFESP) Centro Brasileiro de Informações sobre Drogas Psicotrópicas Departamento de PsicobiologiaPrefeitura Municipal de Santo André Secretaria da Saúde Departamento de Assistência à SaúdeUNIFESP, Centro Brasileiro de Informações sobre Drogas Psicotrópicas Depto. de PsicobiologiaSciEL

Omega-3 fatty acids: possible neuroprotective mechanisms in the model of global ischemia in rats

Background. Omega-3 (omega 3) administration was shown to protect against hypoxic-ischemic injury. The objectives were to study the neuroprotective effects of omega 3, in a model of global ischemia. Methods. Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion. The groups were SO, untreated ischemic and ischemic treated rats with omega 3 (5 and 10 mg/kg, 7 days). The SO and untreated ischemic animals were orally treated with 1% cremophor and, 1 h after the last administration, they were behaviorally tested and euthanized for neurochemical (DA, DOPAC, and NE determinations), histological (Fluoro jade staining), and immunohistochemical (TNF-alpha, COX-2 and iNOS) evaluations. The data were analyzed by ANOVA and Newman-Keuls as the post hoc test. Results. Ischemia increased the locomotor activity and rearing behavior that were partly reversed by omega 3. Ischemia decreased striatal DA and DOPAC contents and increased NE contents, effects reversed by omega 3. This drug protected hippocampal neuron degeneration, as observed by Fluoro-Jade staining, and the increased immunostainings for TNF-alpha, COX-2, and iNOS were partly or totally blocked by omega 3. Conclusion. This study showed a neuroprotective effect of omega 3, in great part due to its anti-inflammatory properties, stimulating translational studies focusing on its use in clinic for stroke managing.Faculty of Medicine, Estácio of Juazeiro do Norte (FMJ), Rua Tenente Raimundo Rocha 515, 63040-360 Juazeiro do Norte, CE, BrazilFederal University of Ceará (UFC), Rua Coronel Nunes de Melo 1127, 60430-270 Fortaleza, CE, BrazilFederal University of São Paulo (UNIFESP), Rua Pedro de Toledo 669, 04039-032 São Paulo, SP, BrazilFederal University of São Paulo (UNIFESP), Rua Pedro de Toledo 669, 04039-032 São Paulo, SP, BrazilWeb of Scienc

In vitro evaluation of alkaline lignins as antiparasitic agents and their use as an excipient in the release of benznidazole

Copyright © 2023. Published by Elsevier B.V.The Amazon rainforest is considered the largest tropical timber reserve in the world. The management of native forests in the Amazon is one of the most sensitive geopolitical issues today, given its national and international dimension. In this work, we obtained and characterized physicochemical lignins extracted from branches and leaves of Protium puncticulatum and Scleronema micranthum. In addition, we evaluated in vitro its potential as an antioxidant, cytotoxic agent against animal cells and antiparasitic against promastigotes of Leishmania amazonensis, trypomastigotes of T. cruzi and against Plasmodium falciparum parasites sensitive and resistant to chloroquine. The results showed that the lignins obtained are of the GSH type and have higher levels of guaiacyl units. However, they show structural differences as shown by spectroscopic analysis and radar charts. As for biological activities, they showed antioxidant potential and low cytotoxicity against animal cells. Antileishmanial/trypanocidal assays have shown that lignins can inhibit the growth of promastigotes and trypomastigotes in vitro. The lignins in this study showed low anti-Plasmodium falciparum activity against susceptible strains of Plasmodium falciparum and were able to inhibit the growth of the chloroquine-resistant strain. And were not able to inhibit the growth of Schistosoma mansoni parasites. Finally, lignins proved to be promising excipients in the release of benznidazole. These findings show the potential of these lignins not yet studied to promote different biological activities.publishersversionpublishe