Consider the guidance of the way on radiation and health in kindergarten, elementary and junior high schools consistently: Efforts on radiation education based on viewpoints of health education and science education

平成23年の東日本大震災による福島第一原発事故の災害により，福島県民の健康不安や周りの者からの風評被害が社会問題となり，教育現場においてもいじめなどの深刻な人権問題が生じた。そのことから，今後は，子ども達の放射線に関する基礎的知識の習得，放射線に関する課題についての思考・判断能力の育成が求められると考えられる。 本研究では，発達段階の違いを考慮した上で，実態に即した学習内容を検討するために小学６年生と中学３年生に「放射線に関する認識について」の調査を実施し，実態を比較検討した。その調査結果から，放射線についての教育プログラムを開発検討するにあたり，放射線についての正しい知識を身につけ，より実生活と結びついた教育内容を展開する必要があると考えた。研究結果として，小学６年生と中学３年生では放射線に関する認識・知識に大きな差が見られなかったことから，小学６年生と中学３年生の児童生徒が合同で放射線に関する学習プログラムを展開し，発達段階の異なる者同士が意見交換をしながら思考・判断能力を育むという，学習の相乗効果を見込んだ働きかけも可能であると考えられた。Due to the Fukushima Daiichi nuclear accident due to the Great East Japan Great Earthquake of 2011, damage caused by Fukushima citizen's health and rumors became a social problem and human rights problems such as bullying also occurred in the educational setting. From that, it is required to acquire basic knowledge on children's radiation and to develop thought / judgment abilities. In this research, we aimed to develop radiation education programs by conducting a survey on "radiation recognition perception" in elementary and junior high school students and junior high school graders. As a result, since there was no significant difference in elementary and junior high school students' recognition and knowledge, we thought that synergistic effects of learning can be expected by developing a learning program that elementary school students and junior high school students can jointly perform

Safety education in school based on the report of the Central Educatio Council : The systematic school hygiene safety sducation connected with body,mind,food and nutrition in a kindergarten, an elementary school, an junior high school

近年,大規模な自然災害や子どもが被害者となる事件や事故,災害が多発している。また,子どもの健康課題は多様化・深刻化しており,食教育の在り方が問われている。そこで本研究では,家庭での保護者の意識や教育力を把握し,分析した結果とその後の実践を示すことにした。その結果,家庭で事故やけがに関する会話をよくしている生徒ほど,事故やけがに対する関心が高いことが分かった。食の安全については,保護者・生徒ともに意識が高いが,生徒は意識や知識があってもそれを実際の生活に生かすことは難しい状況にあり,学校で学習したことを実際の生活に生かしていくことができるよう,幼少期から継続して指導を行うことで行動変容を促すことに繋がると考えられる。今後は,子どもたちが主体的に身の回りの危険や状況を判断し,行動できるよう日常の保育教科学習を見据えた取り組みをしていく。そのために子どもたちの発達段階に即した幼少中一貫のモデルプランを開発していきたい

Multiplicative mononuclear small hepatocytes in adult rat liver : Their isolation as a homogeneous population and localization to periportal zone

Adult rat liver contains a minor population of hepatocytes called small hepatocytes (SHs) that are smaller in size and show a higher replicative potential than conventional parenchymal hepatocytes (PHs). However, SHs have been hitherto characterized using a "SH-fraction" that was contaminated with PHs. In the present study, we isolated a PH-free SH-fraction from the adult rat liver using fluorescence-activated cell sorter combined with centrifugal elutriation and characterized the hepatocytes in the fraction. These hepatocytes were designated R3Hs in this study. R3Hs were mononuclear and of lower ploidy. They expressed at high levels genes of Cdc2, connexin 26, hydroxysteroid sulfotransferase, pancreatic secretory trypsin inhibitor, and prostaglandin E2 receptor EP3 subtype. We conclude that SHs dominate the periportal zone in the adult liver, because mRNA or proteins of these genes were exclusively expressed by periportal hepatocytes

Identification of a Crucial Site for Synoviolin Expression

Synoviolin is an E3 ubiquitin ligase localized in the endoplasmic reticulum (ER) and serving as ER-associated degradation system. Analysis of transgenic mice suggested that synoviolin gene dosage is implicated in the pathogenesis of arthropathy. Complete deficiency of synoviolin is fatal embryonically. Thus, alternation of Synoviolin could cause breakdown of ER homeostasis and consequently lead to disturbance of cellular homeostasis. Hence, the expression level of Synoviolin appears to be important for its biological role in cellular homeostasis under physiological and pathological conditions. To examine the control of protein level, we performed promoter analysis to determine transcriptional regulation. Here we characterize the role of synoviolin transcription in cellular homeostasis. The Ets binding site (EBS), termed EBS-1, from position −76 to −69 of the proximal promoter, is responsible for synoviolin expression in vivo and in vitro. Interestingly, transfer of EBS-1 decoy into NIH 3T3 cells conferred not only the repression of synoviolin gene expression but also a decrease in cell number. Fluorescence-activated cell sorter analysis using annexin V staining confirmed the induction of apoptosis by EBS-1 decoy and demonstrated recovery of apoptosis by overexpression of Synoviolin. Our results suggest that transcriptional regulation of synoviolin via EBS-1 plays an important role in cellular homeostasis. Our study provides novel insight into the transcriptional regulation for cellular homeostasis