SYNTHESIS AND EFFECTS OF SOME NEW 2-ARYL-THIAZOLE AMMONIUM SALTS ON ISOLATED ILEUM MOTILITY

Quaternary ammonium compounds are considered among the substances which can influence the contractility of smooth muscles from the digestive tract, acting via cholinergic mechanisms. Based on structural considerations, we synthesized twelve new compounds, derivatives of 2-aryl-thiazole, being substituted in the 2 and 4 positions. In order to elucidate the structure of the obtained compounds, MS determinations and 1 H-NMR spectra were realized. The effect on the smooth muscles was tested using the guinea pig isolated ileum experimental model. The obtained results showed that the contractile effects or the antispasmodic activity of the compounds are influenced by the nature of the substituent in the 4 position, and the intensity of the effect is related to the type of substituent on the phenyl, from the 2 position of the thiazolic nucleus