Viajamos al mundo exterior: herramienta didáctica para gamificar las ciencias sociales en Educación Primaria

La gamificación es una metodología activa en auge consistente en utilizar elementos y técnicas pertenecientes al juego en ambientes no lúdicos, como el educativo, con la finalidad de aumentar el interés de los discentes y, por lo tanto, mejorar su proceso de aprendizaje. Viajamos al mundo exterior es un recurso TIC de gamificación que pretende apoyar a profesores, familias y discentes en el proceso de enseñanza aprendizaje de las Ciencias Sociales (específicamente el Mundo Exterior) para alumnos de 3er curso de Educación Primaria entre cuyas principales dificultades se encuentran la falta de motivación del estudiante y la falta de formación científica del profesorado. En su diseño, se han tenido en cuenta todos los aspectos curriculares atendiendo la legislación vigente y se han definido los elementos de la gamificación. Partiendo de una noticia donde nuestro protagonista, Max, pide ayuda para combatir a la familia Guca que quiere conquistar todos los planetas, se han diseñado una serie de retos donde los alumnos irán obteniendo puntos que podrán canjear por recompensas individuales y grupales e ir subiendo de nivel. Se presenta el diseño de la secuencia didáctica completa, propuesta para llevarse a cabo en 10 sesiones, donde se incluye el sistema de evaluación

DNA extraction as a didactic strategy to learn about the cell in primary and secondary education

Today’s society is widely influenced by the great scientific and technological advances that have been developed since the last century. This implies that citizens face in their daily problematic situations that require the implementation of scientific skills, establishing the importance of the development of scientific literacy, which allows reflection, reasoning and the establishment of connections to solve them satisfactorily. In this sense, practical work is an optimal tool in the classroom, since they place students at the center of the teaching-learning process, seeking solutions to facts that are part of their daily lives through observation and manipulation, transforming them into school scientific facts and thus acquiring new knowledge. Therefore, this work analyzes a practical experience: DNA extraction. To this end, the structure of DNA is presented, the steps that are usually carried out in any process of extraction of this macromolecule are analyzed and a proposal is designed for Primary Education and another for Compulsory Secondary Education in which students extract DNA from everyday material and acquire knowledge about its structure following the scientific method. As results, both proposals have been validated through an expert judgment, highlighting that they are innovative and attractive to students. In conclusion, it is recommended to implement the proposals as well as to take into account the time needed for their development and the importance of the number of students present in the classroom.La sociedad actual está ampliamente influenciada por los grandes adelantos científicos y tecnológicos que se han desarrollado desde el siglo pasado. Esto implica que la ciudadanía se enfrenta diariamente a situaciones problemáticas que requieren la puesta en marcha de competencias científicas, estableciendo la importancia del desarrollo de la alfabetización científica, que permite la reflexión, el razonamiento y el establecimiento de conexiones para resolverlas de manera satisfactoria. En este sentido, los trabajos de tipo práctico suponen una herramienta óptima en las aulas, puesto que sitúan al alumnado en el centro del proceso de enseñanza-aprendizaje, buscando soluciones a hechos que forman parte de su vida cotidiana mediante la observación y la manipulación, transformándolos en hechos científicos escolares y adquiriendo así nuevos conocimientos. Por todo ello, en este trabajo se analiza una experiencia práctica: la extracción de ADN. A tal efecto, se presenta la estructura de ADN, se analizan los pasos que suelen llevarse a cabo en cualquier proceso de extracción de esta macromolécula y se diseña una propuesta para Educación Primaria y otra para Educación Secundaria Obligatoria en las que los estudiantes extraen ADN de material cotidiano y adquieren conocimientos sobre su estructura siguiendo el método científico. Como resultados, ambas propuestas han sido validadas a través de un juicio de expertos destacando que son innovadoras y atractivas para los alumnos. Como conclusión se recomienda implementar las propuestas, así como tener en cuenta el tiempo necesario para su desarrollo y la importancia del número de alumnos presentes en el aula

Development and Validation of a Prediction Model and Score for Transthyretin Cardiac Amyloidosis Diagnosis: T-Amylo

Amyloidosis; Prediction model; TransthyretinAmiloïdosi; Model de predicció; TranstiretinaAmiloidosis; Modelo de predicción; TranstiretinaBackground Although transthyretin cardiac amyloidosis (ATTR-CA) is often underdiagnosed, clinical suspicion is essential for early diagnosis. Objectives The aim of this study was to develop and validate a feasible prediction model and score to facilitate the diagnosis of ATTR-CA. Methods This retrospective multicenter study enrolled consecutive patients who underwent 99mTc-DPD scintigraphy for suspected ATTR-CA. ATTR-CA was diagnosed if Grade 2 or 3 cardiac uptake was evidenced on 99mTc-DPD scintigraphy in the absence of a detectable monoclonal component or by demonstration of amyloid by biopsy. A prediction model for ATTR-CA diagnosis was developed in a derivation sample of 227 patients from 2 centers using multivariable logistic regression with clinical, electrocardiography, analytical, and transthoracic echocardiography variables. A simplified score was also created. Both of them were validated in an external cohort (n = 895) from 11 centers. Results The obtained prediction model combined age, gender, carpal tunnel syndrome, interventricular septum in diastole thickness, and low QRS interval voltages, with an area under the curve (AUC) of 0.92. The score had an AUC of 0.86. Both the T-Amylo prediction model and the score showed a good performance in the validation sample (ie, AUC: 0.84 and 0.82, respectively). They were tested in 3 clinical scenarios of the validation cohort: 1) hypertensive cardiomyopathy (n = 327); 2) severe aortic stenosis (n = 105); and 3) heart failure with preserved ejection fraction (n = 604), all with good diagnostic accuracy. Conclusions The T-Amylo is a simple prediction model that improves the prediction of ATTR-CA diagnosis in patients with suspected ATTR-CA.Part of this project was funded by Pfizer through an independent general research grant (number 64764667). This study has been partially funded by Instituto de Salud Carlos III through the project "PI20/01379” (co-funded by European Regional Development Fund/European Social Fund "A way to make Europe"/"Investing in your future"). The CNIC is supported by the ISCIII, MCIN, the Pro-CNIC Foundation, and the Severo Ochoa grant (CEX2020-001041-S). Dr Basurte Elorz has received a consultant fee from Pfizer. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose

Evaluation of the user experience of an industrial robotic environment in virtual reality

Industry 4.0 is leading to a whole new level of process automation, thus redefining the role of humans, and altering existing jobs in yet unknown ways. Although the number of robots in the manufacturing industry has been steadily increasing for several decades, the current growth trend is remarkable given the number and variety of industries using robots. Operators need to have positive and fit-for-purpose experiences through trust-based, smooth, safe, and satisfying interaction to integrate robots as a natural part of their daily lives. In this sense, virtual reality is presented as an optimal technology to evaluate this interaction while ensuring safe conditions, but the impact it has on human factors still has unknowns to be solved. This research paper presents an evaluation study of the human factors resulting from collaboration with an industrial robot in a virtual environment taking into account the gender perspective. For this purpose, the behaviour of the users (n=8) has been analysed and the interaction has been evaluated by means of two questionnaires to correlate task performance and subjective perception.La Industria 4.0 está conduciendo a un nivel completamente nuevo de automatización de procesos, redefiniendo así el papel de las personas y alterando los puestos de trabajo existentes en formatos aún desconocidos. Aunque el número de robots en la industria manufacturera no ha dejado de aumentar desde hace varias décadas, la tendencia actual de crecimiento es notable dado el número y la variedad de industrias que utilizan robots. Los operarios deben tener experiencias positivas y adecuadas a su propósito mediante una interacción basada en la confianza, fluida, segura y satisfactoria para integrar los robots como parte natural de su cotidianeidad. En este sentido, la realidad virtual se presenta como una tecnología óptima para evaluar esta interacción garantizando condiciones de seguridad, pero el impacto que tiene en los factores humanos todavía tiene incógnitas por resolver. Este trabajo de investigación presenta un estudio de evaluación de los factores humanos resultantes de la colaboración con un robot industrial en un entorno virtual teniendo en cuenta la perspectiva de género. Para ello, se ha analizado el comportamiento de los usuarios (n=8) y se ha evaluado la interacción mediante dos cuestionarios para correlacionar el rendimiento de la tarea y la percepción subjetiva

La microbiología en la XI edición de ZIENTZIASTEA, la semana de la ciencia, la tecnología y la innovación de UPV/EHU

Poster presentado a la XI Semana de la Ciencia, Tecnología y la Innovación celebrada del 9 al 13 de noviembre de 201

Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study

Methods: We examined whether immune cell profiles differ between healthy women (n = 38) and breast cancer survivors (n = 27) within 2 years of treatment, and whether any group-differences were influenced by age, cytomegalovirus infection, cardiorespiratory fitness and body composition. Using flow cytometry, CD4+ and CD8+ T cell subsets, including naïve (NA), central memory (CM) and effector cells (EM and EMRA) were identified using CD27/CD45RA. Activation was measured by HLA-DR expression. Stem cell-like memory T cells (TSCMs) were identified using CD95/CD127. B cells, including plasmablasts, memory, immature and naïve cells were identified using CD19/CD27/CD38/CD10. Effector and regulatory Natural Killer cells were identified using CD56/CD16. Results: Compared to healthy women, CD4+ CM were +Δ21% higher among survivors (p = 0.028) and CD8+ NA were −Δ25% lower (p = 0.034). Across CD4+ and CD8+ subsets, the proportion of activated (HLA-DR+) cells was +Δ31% higher among survivors: CD4+ CM (+Δ25%), CD4+ EM (+Δ32%) and CD4+ EMRA (+Δ43%), total CD8+ (+Δ30%), CD8+ EM (+Δ30%) and CD8+ EMRA (+Δ25%) (p 0.305, p < 0.019). The association between fat mass index and HLA-DR+ CD8+ EMRA T cells withstood statistical adjustment for all variables, including age, CMV serostatus, lean mass and cardiorespiratory fitness, potentially implicating these cells as contributors to inflammatory/immune-dysfunction in overweight/obesity

A phenomic perspective on factors influencing breast cancer treatment: integrating aging and lifestyle in blood and tissue biomarker profiling

Breast cancer is the most common malignancy among women worldwide. Over the last four decades, diagnostic and therapeutic procedures have improved substantially, giving patients with localized disease a better chance of cure, and those with more advanced cancer, longer periods of disease control and survival. However, understanding and managing heterogeneity in the clinical response exhibited by patients remains a challenge. For some treatments, biomarkers are available to inform therapeutic options, assess pathological response and predict clinical outcomes. Nevertheless, some measurements are not employed universally and lack sensitivity and specificity, which might be influenced by tissue-specific alterations associated with aging and lifestyle. The first part of this article summarizes available and emerging biomarkers for clinical use, such as measurements that can be made in tumor biopsies or blood samples, including so-called liquid biopsies. The second part of this article outlines underappreciated factors that could influence the interpretation of these clinical measurements and affect treatment outcomes. For example, it has been shown that both adiposity and physical activity can modify the characteristics of tumors and surrounding tissues. In addition, evidence shows that inflammaging and immunosenescence interact with treatment and clinical outcomes and could be considered prognostic and predictive factors independently. In summary, changes to blood and tissues that reflect aging and patient characteristics, including lifestyle, are not commonly considered clinically or in research, either for practical reasons or because the supporting evidence base is developing. Thus, an aim of this article is to encourage an integrative phenomic approach in oncology research and clinical management

Effectiveness of a Structured Group Intervention Based on Pain Neuroscience Education for Patients with Fibromyalgia in Primary Care: a Multicentre Randomized Open-Label Controlled Trial

Background There has been increased interest in pain neuroscience education (PNE) as a therapeutic approach for the management of fibromyalgia (FM). Methods A multicentre randomized, open-label, controlled trial was conducted to assess the effectiveness of a structured group intervention based on PNE in patients with FM. A total of 139 patients were included in the study and randomized to the intervention group (7 group sessions of education in neurobiology of pain) or to the control group (treatment as usual only). The primary outcome was the improvement of functional status and pain measured with the Fibromyalgia Impact Questionnaire (FIQ), and secondary outcomes were the reduction in the impact of pain and other symptoms (catastrophizing, anxiety and depression) and number of patients reaching no worse than moderate functional impairment (FIQ score <39). Differences between groups were calculated by linear mixed-effects (intention-to-treat approach) and mediational models through path analyses. Results At 1 year, improvements in FIQ scores were higher in the intervention group with moderate or high effect size, and decreases of >= 20% in 69.1% of patients (20.9% in the control group) and of >= 50% in 39.7% (4.5% in the control group). Also, 52.9% of patients had a FIQ <39 points (13.4% in the control group). Conclusions In this sample of patients with FM, the improvement in quality of life and control of symptoms obtained by adding a PNE intervention showed promising results, equalling or surpassing previously reported outcomes. Significance A structured group intervention based on pain neuroscience education for 1 year in patients with fibromyalgia was associated with significant amelioration of the impact of the disease on scores of the Fibromyalgia Impact Questionnaire, the Health Assessment Questionnaire, the Hospital Anxiety and Depression Scale, the Pain Catastrophizing Scale and the Polysymptomatic Distress Scale as compared with only treatment as usual. These findings are clinically relevant considering the challenges posed by fibromyalgia to clinicians and patients alike.Partial reduction of routine work tasks of the principal investigator, MJ Barrenengoa-Cuadra, was supported by a grant from OSI Bilbao Basurto Osakidetza, Basque country, Spain (the grant was paid to the Health Service to substitute MJ Barrenengoa-Cuadra while research work)

Revisión bibliográfica sobre la sintomatología cognitiva en la malformación de Chiari tipo I

Chiari malformation (CM) is a rare pathology with low prevalence. CM is within the group of malformations of the craniocervical junction, it is an anatomical alteration of the cranial base. There are considered to be 6 types of CM, being MC type I the most common one. &nbsp;The symptomatology can be very varied, having been reported cases of totally asymptomatic patients and others with serious neurological affections. Furthermore, recent research shows that congenital pathologies of the cerebellum such as CM can be accompanied by neuropsychological deficits. It is difficult to diagnose it due to the complexity of the lesion and the symptoms present in patients. However, the diagnosis is made by neuroimaging techniques, being the most widely used technique the magnetic resonance. Regarding to treatment, surgery is one of the main actions to be carried out after the diagnosis of CM. This review presents an exhaustive analysis of the existing literature on the cognitive functions affected of type I MC. It also describes the effects of surgical treatments on neuropsychological symptoms. The results show the presence of cognitive deficits; however, there is no agreement about exactly what cognitive functions are affected.La malformación de Chiari (MC) es una patología rara de baja prevalencia y cuya patogenia actualmente sigue siendo objeto de debate. La MC está dentro del grupo de las malformaciones de la unión craneocervical, es una alteración anatómica de la base craneal. A día de hoy se considera que hay 6 tipos de MC, siendo la MC tipo I la más común. La sintomatología puede ser muy variada habiéndose reportado casos de pacientes totalmente asintomáticos y otros con graves afecciones de tipo neurológicas. Recientes investigaciones manifiestan que las patologías congénitas del cerebelo como la MC, pueden acompañarse de déficits neuropsicológicos. Es de difícil diagnóstico debido a la complejidad de la lesión y sintomatología presente en los pacientes. No obstante, el diagnóstico se realiza mediante técnicas de neuroimagen siendo la técnica más utilizada la resonancia magnética. En cuanto al tratamiento, la cirugía es una de las principales actuaciones a llevar a cabo ante el diagnóstico de MC. Esta revisión presenta un análisis exhaustivo de la literatura existente sobre las funciones cognitivas afectadas de la MC tipo I. Asimismo, realiza una descripción de los efectos de los tratamientos quirúrgicos en la sintomatología neuropsicológica. Los resultados evidencian la presencia de déficits cognitivos; sin embargo, no hay acuerdo sobre cuáles son exactamente las funciones cognitivas afectadas