Mouse models of primary aldosteronism: from physiology to pathophysiology

Primary aldosteronism (PA) is a common form of endocrine hypertension that is characterized by the excessive production of aldosterone relative to suppressed plasma renin levels. PA is usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Somatic mutations have been identified in several genes that encode ion pumps and channels that may explain the aldosterone excess in over half of aldosterone-producing adenomas, whereas the pathophysiology of bilateral adrenal hyperplasia is largely unknown. A number of mouse models of hyperaldosteronism have been described that recreate some features of the human disorder although none replicate the genetic basis of human PA. Animal models that reproduce the genotype-phenotype associations of human PA are required to establish the functional mechanisms that underlie the endocrine autonomy and deregulated cell growth of the affected adrenal and for preclinical studies of novel therapeutics. Herein, we discuss the differences in adrenal physiology across species and describe the genetically-modified mouse models of PA that have been developed to date

Danzando bajo el hain: cuidados, cuerpos y territorios afectados por la pandemia

La publicación es el resultado de la investigación sobre el impacto del COVID-19 en la vida de las mujeres afrodescendientes, originarias, campesinas, migrantes, trans, disidencias, trabajadoras de cooperativas, de la economía solidaria y de barrios populares.Fil: Bidaseca, Karina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Altos Estudios Sociales; ArgentinaFil: Aragao Guimaraes Costa, Michelly. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Brighenti, Maura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Altos Estudios Sociales; ArgentinaFil: Ruggero, Santiago. No especifíca;Fil: García Corredor, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Altos Estudios Sociales; ArgentinaFil: Nuñez Lodwick, Lucía Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Altos Estudios Sociales; ArgentinaFil: Moura, Karina Violeta. No especifíca;Fil: Wappner, Lucía. No especifíca;Fil: Molino, Agustina. No especifíca;Fil: Núñez Iglesias, Javier. No especifíca;Fil: Virosta, Leticia Irene. No especifíca