3 research outputs found
Mouse models of primary aldosteronism: from physiology to pathophysiology
Primary aldosteronism (PA) is a common form of endocrine hypertension that is characterized by the excessive production of aldosterone relative to suppressed plasma renin levels. PA is usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Somatic mutations have been identified in several genes that encode ion pumps and channels that may explain the aldosterone excess in over half of aldosterone-producing adenomas, whereas the pathophysiology of bilateral adrenal hyperplasia is largely unknown. A number of mouse models of hyperaldosteronism have been described that recreate some features of the human disorder although none replicate the genetic basis of human PA. Animal models that reproduce the genotype-phenotype associations of human PA are required to establish the functional mechanisms that underlie the endocrine autonomy and deregulated cell growth of the affected adrenal and for preclinical studies of novel therapeutics. Herein, we discuss the differences in adrenal physiology across species and describe the genetically-modified mouse models of PA that have been developed to date
Thyroid Hormone Beta Receptor Mutation Causes Renal Dysfunction and Impairment of ClC-2 Chloride Channel Expression in Mouse Kidney
Danzando bajo el hain: cuidados, cuerpos y territorios afectados por la pandemia
La publicaciĂłn es el resultado de la investigaciĂłn sobre el impacto del COVID-19 en la vida de las mujeres afrodescendientes, originarias, campesinas, migrantes, trans, disidencias, trabajadoras de cooperativas, de la economĂa solidaria y de barrios populares.Fil: Bidaseca, Karina Andrea. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de San MartĂn. Instituto de Altos Estudios Sociales; ArgentinaFil: Aragao Guimaraes Costa, Michelly. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Brighenti, Maura. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de San MartĂn. Instituto de Altos Estudios Sociales; ArgentinaFil: Ruggero, Santiago. No especifĂca;Fil: GarcĂa Corredor, Laura. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de San MartĂn. Instituto de Altos Estudios Sociales; ArgentinaFil: Nuñez Lodwick, LucĂa Jimena. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de San MartĂn. Instituto de Altos Estudios Sociales; ArgentinaFil: Moura, Karina Violeta. No especifĂca;Fil: Wappner, LucĂa. No especifĂca;Fil: Molino, Agustina. No especifĂca;Fil: NĂșñez Iglesias, Javier. No especifĂca;Fil: Virosta, Leticia Irene. No especifĂca