26 research outputs found
High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea and premenstrual syndrome in adolescents
Vitamin D has a crucial role in female reproduction, possibly through its effects on calcium homeostasis, cyclic sex steroid hormone fluctuations, or neurotransmitter function. We have assessed the effects of vitamin D supplementation on dysmenorrhea and premenstrual syndrome (PMS) in adolescents. In this study, 897 adolescent girls living in Mashhad and Sabzevar, Iran, received 9 high-dose vitamin D supplements (as 50000 IU/ week of cholecalciferol) and were followed up over 9 weeks. We evaluated the effect of vitamin D supplementation on individuals in 4 categories: those with only PMS; individuals with only dysmenorrhea; subjects with both PMS and dysmenorrhea and normal subjects. The prevalence of PMS after the intervention fell from 14.9% to 4.8% (P<0.001). Similar results were also found for the prevalence of subjects with dysmenorrhea (35.9% reduced to 32.4%), and in subjects with both PMS and dysmenorrhea (32.7% reduced 25.7%). Vitamin D supplementation was associated with a reduction in the incidence of several symptoms of PMS such as backache and tendency to cry easily as well decrement in pain severity of dysmenorrhea (P<0.05). High dose vitamin D supplementation can reduced the prevalence of PMS and dysmenorrhea as well has positive effects on the physical and psychological symptoms of PMS
Delamanid-containing regimens and multidrug-resistant tuberculosis: A systematic review and meta-analysis
Introduction: Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening condition needing long poly-chemotherapy regimens. As no systematic reviews/meta-analysis is available to comprehensively evaluate the role of delamanid (DLM), we evaluated its effectiveness and safety. Methods: We reviewed the relevant scientific literature published up to January 20, 2022. The pooled success treatment rate with 95% confidence intervals (CI) was assessed using a random-effect model. We assessed studies for quality and bias, and considered P0.05). The overall pooled treatment success rate in DLM and bedaquiline-containing regimens was 75.2% (95% CI 68.1-81.1) with no evidence of publication bias (Begg's test; P >0.05). In experimental studies the pooled treatment success rate of DLM-containing regimens was 72.5 (95% CI 44.2-89.8, P 0.05). Conclusions: In MDR-TB patients receiving DLM, culture conversion and treatment success rates were high despite extensive resistance with limited adverse events
The highest prevalence of human metapneumovirus in Ahwaz children accompanied by acute respiratory infections
Purpose: The newly described human metapneumovirus (hMPV) has been
recently discovered as an etiological agent of acute respiratory
infections (ARTI) in infants and children. The aim of this study was to
determine the prevalence of hMPV and its potential role as causative
agent of ARTI in Ahwaz children. Methods: In the present study, we
examined 124 nasal swabs from infants affected by ARTI for the presence
of hMPV by RT-PCR technique. Results: Sixty-eight out of 124 (54.4%)
cases were positive for hMPV which is the highest incidence of hMPV
ever reported in the world, 94.1% of positive cases belonged to
genotype A; whereas no B genotype was detected. Our positive hMPV
children were affected by upper (URTI) as well as lower respiratory
tract infection (LRTI); however, LARTIs had higher prevalence.
Conclusions: We suggest a probable role of F protein alteration as the
causative agent for the highest prevalence of hMPV infection among
Ahvaz children