In Vivo Tissue Regeneration with Robotic Implants

Robots that reside inside the body to restore or enhance biological function have long been a staple of science fiction. Creating such robotic implants poses challenges both in signaling between the implant and the biological host as well as in implant design. To investigate these challenges, we created a robotic implant to perform in vivo tissue regeneration via mechano-stimulation. The robot is designed to induce lengthening of tubular organs, such as the esophagus and intestines, by computer-controlled application of traction forces. Esophageal testing in swine demonstrates that the applied forces can induce cell proliferation and lengthening of the organ without a reduction in diameter, while the animal is awake, mobile and able to eat normally. Such robots can serve as research tools for studying mechanotransduction-based signaling and can also be employed clinically for conditions such as long-gap esophageal atresia and short bowel syndrome

ASSESSMENT OF THE EFFECT OF ANESTHESIA METHODS ON HRV AND PAIN SYNDROME AFTER SEPTOPLASTY

Aims: to evaluate various methods of anesthesia during septoplasty for changes in heart rate variability (HRV) and acute pain syndrome in the early postoperative period. Patients and methods. All patients received local anesthesia with 2% procaine solution. In group 1(105 people) premedication was used with 2% promedol solution and 60 mg of ketorolac in the evening, in group 2 (108 people) -fentanyl, propofol, cisatracuria besylate, tranexamic acid, atropine and metoclopramide, in group 3 (78 people) - atracuria besylate, sodium thiopental, nitrous oxide and halothane. In groups 2 and 3, 100 mg of ketoprofen was administered intramuscularly in the evening on the day of surgery. The frequency domain of HRV was estimated per day. Pain was assessed using a visual analogue scale (VAS). Results. ULF and LF were significantly higher in groups 2 and 3 than in the local anesthetic group. VLF in the second group was significantly lower than in groups 1 and 3. Groups 2 and 3 had low HF. The VHF of group 2 was significantly lower than in groups 1 and 3, which also differed from each other - the VHF values in group 1 were higher than in group 2. Total power in group 2 was significantly lower than in groups 1 and 3. Pain syndrome was less pronounced in group 2. Conclusion. The following scheme may be less stressful when performing septopalstics for general anesthesia: fentanyl, propofol, cisatracuria besylate, tranexamic acid, atropine and metoclopramide