2,224 research outputs found

    Calculating Biological Behaviors of Epigenetic States in Phage lambda Life Cycle

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    Gene regulatory network of lambda phage is one the best studied model systems in molecular biology. More 50 years of experimental study has provided a tremendous amount of data at all levels: physics, chemistry, DNA, protein, and function. However, its stability and robustness for both wild type and mutants has been a notorious theoretical/mathematical problem. In this paper we report our successful calculation on the properties of this gene regulatory network. We believe it is of its first kind. Our success is of course built upon numerous previous theoretical attempts, but following 3 features make our modeling uniqu: 1) A new modeling method particular suitable for stability and robustness study; 2) Paying a close attention to the well-known difference of in vivo and in vitro; 3) Allowing more important role for noise and stochastic effect to play. The last two points have been discussed by two of us (Ao and Yin, cond-mat/0307747), which we believe would be enough to make some of previous theoretical attempts successful, too. We hope the present work would stimulate a further interest in the emerging field of gene regulatory network.Comment: 16 pages, 3 figures, 1 tabl

    Phase slip in a superfluid Fermi gas near a Feshbach resonance

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    In this paper, we study the properties of a phase slip in a superfluid Fermi gas near a Feshbach resonance. The phase slip can be generated by the phase imprinting method. Below the superfluid transition temperature, it appears as a dip in the density profile, and becomes more pronounced when the temperature is lowered. Therefore the phase slip can provide a direct evidence of the superfluid state. The condensation energy of the superfluid state can be extracted from the density profile of the phase slip, due to the unitary properties of the Fermi gas near the resonance. The width of the phase slip is proportional to the square root of the difference between the transition temperature and the temperature. The signature of the phase slip in the density profile becomes more robust across the BCS-BEC crossover.Comment: 5 pages, 2 figures, the density profile of a phase slip under experimental conditions was calculate

    WNT Signaling in the early development of Zebrfish Swimbladder and Xenopus Lung

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