Burkitt's Lymphoma as Primary Adrenal Lymphoma Diagnosed on Fine Needle Aspiration Cytology : A Rare Case Report

Introduction :Primary adrenal lymphoma presenting as Burkitt’s lymphoma  is an extremely rare entity. Although biopsy or excision is often needed for definitive diagnosis computed tomography guided fine needle aspiration has great diagnostic value in detection of primary adrenal lymphoma.Presentation of case : A case  of a 20 yr old male with a right adrenal mass diagnosed as Burkitts lymphoma on Fine Needle Aspiration Cytology (confirmed by bone marrow and cytogenetics) has been reported.Conclusion : Fine Needle Aspiration Cytology  as an initial investigation tool can be very effective for detection of unusual presentation like an adrenal mass in a case of Burkitt's lymphom

Familial disseminated plaque type porokeratosis with multiple horns and squamous cell carcinoma involving anal skin

Porokeratosis is a disorder of keratinization showing a well-defined lesion with a hyperkeratotic ridge on the border that contains the coronoid lamella. We report familial (autosomal dominant with reduced penetrance) disseminated plaque type (Mibelli′s type) porokeratosis in a father and son. In the father, there were multiple horns and a large squamous cell carcinoma in a large lesion over the perianal region that reached up to the squamo-columnar junction of the anal mucosa and even invaded the anal sphincteric muscles. Disseminated lesions of the Mibelli′s type, development of horns, and malignancy in this unusual location have not been previously reported

A case of prolonged fever with pulmonary nodules-looking beyond neoplasms

We present an unusual case of a middle aged female without other known co-morbidities presenting clinically with isolated prolonged fever and a radiological evidence of persisting focal lung opacity mimicking neoplasm. She was subsequently diagnosed to have nonspecific interstitial pneumonia on video-assisted thoracoscopic surgery guided lung biopsy. She responded excellently to oral corticosteroids both clinically and radiologically. This case illustrated the need to think beyond infective and neoplastic etiologies in a patient with persistent lung nodule

Hepatoblastoma in the neonatal period: An unusual presentation

Hepatoblastoma (HBL) is a rare primary malignant liver tumor affecting mainly pediatric patients in the age group 6 months to 3 years. Presentation of HBL in the neonatal period is rare. HBL can be diagnosed on cytology along with subtyping. Estimation of serum alpha-fetoprotein (AFP) is essential as a tumor marker. Fetal type HBL usually shows high AFP level. In this report, diagnosis of HBL in a 10-day-old baby with low serum AFP is being described for its unusual presentation

Cytology microarray on cell block preparation: A novel diagnostic approach in fluid cytology

Background: The cytological examination of serous body effusions to diagnose and stage malignancy is well accepted in clinical medicine. Conventional smear (CS) and cell block (CB) study has to be complemented with immunohistochemistry (IHC) for a definitive diagnosis of malignancy and also to differentiate it from reactive mesothelial cells. Cytology microarray (CMA) is a modification of tissue microarray which involves core needle biopsy of multiple cell blocks and embedding it in a single block. Aim: The aim of this study was to assess the effectiveness of IHC technique in CMA for rapid diagnosis of malignancy and to reduce the cost of testing. Materials and Methods: In this study, 82 pleural fluids were collected and subjected to CS and CB study followed by IHC in CMA blocks. Six commonly used antibodies were applied to confirm malignancy and diagnose the primary. Results: Nineteen cases were diagnosed as malignancy by CB method. MOC-31 confirmed adenocarcinoma deposit in 67% cases of which 44% were proved to be of lung primary by TTF1. Conclusions: IHC on CMA blocks of effusion fluids is a very effective technique that can significantly reduce the cost of testing by >70%