7 research outputs found
Microwave assisted synthesis, characterization and investigation of antibacterial activity of 3-(5- (substituted-phenyl)-4,5-dihydro-1H-pyrazol-3- yl)-2H-chromen-2-one derivatives
A variety of 3-(5-(substituted-phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives
3a–j were synthesized through microwave assisted thermal annulation of corresponding
a,b-unsaturated ketones (chalcones) 2a–j via hydrazinolysis. Chalcones 2a–j were
prepared from 3-acetyl-coumarin 1 which was previously accessed by Pechmann condensation
reaction of salicylaldehyde. The series of pyrazoline-based coumarin motifs 3a–j synthesized,
were structurally confirmed by analytical and spectral data. They were then evaluated
for their antimicrobial activities using agar diffusion method. The result showed that microwave
assisted method (MAM) for the reaction was remarkably successful and gave the targeted
products 3a–j in higher yields at shorter reaction times compared to conventional
synthetic method (CSM). The results showed that these skeletal frameworks exhibited
marked potency as antibacterial agents. The most active antibacterial agent was 3-(5-(4-
(diethylamino) phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-2H-chromen-2-one 3j with MIC and MBC
values of 3.92 ± 0.22 mg/mL and 7.82 ± 0.43 mg/mL respectively.The World Academy of Sciences (TWAS)https://www.tandfonline.com/loi/tabs20am2020Chemistr
Dataset on phytochemical screening, FTIR and GC–MS characterisation of Azadirachta indica and Cymbopogon citratus as reducing and stabilising agents for nanoparticles synthesis
The dataset for this article contains phytochemical and FTIR data for three different extracts from two indigenous medicinal plants obtained from Ogun State, Southwest Nigeria and the GC–MS characterisation data for their ethanolic extracts. To obtain this data, the leaves of Azadirachta indica and Cymbopogon citratus were collected from the premises of Covenant University, Nigeria. The plants were dried, pulverized and extracted with ethanol, distilled water and ethanol:water (50:50), before phytochemical screening (qualitative and quantitative), FTIR and GC–MS analyses were carried out. The dataset provides insight into the presence of bioactive phyto-constituents such as polyphenols and tannins as potential precursors for green-based nanoparticle synthesis