Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules

The association between HLA-B27 and the group of autoimmune inflammatory arthritic diseases, the spondyloarthropathies (SpAs) which include ankylosing spondylitis (AS) and Reactive Arthritis (ReA), has been well established and remains the strongest association between any HLA molecule and autoimmune disease. The mechanism behind this striking association remains elusive; however animal model and biochemical data suggest that HLA-B27 misfolding may be key to understanding its association with the SpAs. Recent investigations have focused on the unusual biochemical structures of HLA-B27 and their potential role in SpA pathogenesis. Here we discuss how these unusual biochemical structures may participate in cellular events leading to chronic inflammation and thus disease progression

Some aspects of the Liouville equation in mathematical physics and statistical mechanics

This paper presents some mathematical aspects of Classical Liouville theorem and we have noted some mathematical theorems about its initial value problem. Furthermore, we have implied on the formal frame work of Stochastic Liouville equation (SLE)

A new SPS programme

A new experiemntal program to study hadron production in hadron-nucleus and nucleus-nucleus collisions at the CERN SPS has been recently proposed by the NA49-future collaboration. The physics goals of the program are: (i) search for the critical point of strongly interacting matter and a study of the properties of the onset of deconfinemnt in nucleus-nucleus collisions, (ii) measurements of correlations, fluctuations and hadron spectra at high transverse momentum in proton-nucleus collisions needed as for better understanding of nucleus-nucleus results, (iii) measurements of hadron production in hadron-nucleus interactions needed for neutrino (T2K) and cosmic-ray (Pierre Auger Observatory and KASCADE) expriments. The physics of the nucleus-nucleus program is reviewed in this presentation

Search for the QCD critical point at SPS energies

Lattice QCD calculations locate the QCD critical point at energies accessible at the CERN Super Proton Synchrotron (SPS). We present average transverse momentum and multiplicity fluctuations, as well as baryon and anti-baryon transverse mass spectra which are expected to be sensitive to effects of the critical point. The future CP search strategy of the NA61/SHINE experiment at the SPS is also discussed.Lattice QCD calculations locate the QCD critical point at energies accessible at the CERN Super Proton Synchrotron (SPS). We present average transverse momentum and multiplicity fluctuations, as well as baryon and anti-baryon transverse mass spectra which are expected to be sensitive to effects of the critical point. The future CP search strategy of the NA61/SHINE experiment at the SPS is also discussed

论创业投资中的风险控制

创业投资是资本市场培育高新技术产业的一种创新的制度安排，有别于一般的投资活动。由于被投资企业的不确定性、交易中信息的高度不对称及投资参与方以外的因素，使得创业投资在获得高收益回报的同时，要承担比一般投资活动大得多的风险，高风险是其核心特征。对风险的有效控制成为创业投资成功获得预期收益的关键。在我国目前这种环境下，由于经济体制和市场机制的缺陷，创业投资蕴含的风险更大，更有必要强调风险控制。全文共分三章，主要内容如下： 第一章比较创业投资与一般投资的主要区别，阐明创业投资风险的特殊性和风险控制的重点。 第二章这是文章的重点，针对创业投资的三个风险来源：被投资企业的不确定性、交易中信息的高度不对...学位：经济学硕士院系专业：经济学院经济系_政治经济学学号：19980900

Measuring Synthesis and Degradation of MHC Class I Molecules

Major histocompatibility complex (MHC) class I molecules function to present pathogen-derived peptides to cytotoxic T cells or act as ligands for Natural Killer cells, thus alerting the immune system to the presence of invading pathogens. Furthermore MHC class I molecules can be strongly associated with autoimmune diseases. Therefore understanding not only the biosynthesis and the degradation pathways of MHC class I molecules has become important in determining their role in pathogen and autoimmune-related diseases. Here we describe how using epitope-tagged MHC class I molecules can aid in the analysis of MHC class I molecule biosynthesis and degradation and also complement studies using conventional conformationally specific antibodies. Coupled together with pharmacological manipulation which can target both biosynthetic and degradative pathways, this offers a powerful tool in analyzing MHC class I molecules