Disseny d’una solució basada en microserveis aplicada al projecte ecoMobility

[CA] En aquest treball exposarem una proposta arquitectònica per a convertir l’arquitectura monolítica d’ecoMobility a una solució orientada als microserveis. Els objectius d’ecoMobility són l’eficiència energética i la reducció d’emissions de gasos contaminants provocats per el tràfic rodat que circula a través de les poblacions. Per a poder abastir aquestos objectius ecoMobility té desplegada una xarxa de sensors a diferents zones de València, aquestos mitjançant gestors de missatgería envíen la informació cap a l’aplicació monolítica encarregada de transformar el missatge “en brut” rebut dels sensors i reenviar la informació processada cap als diferents serveis que gestionen el tràfic de la zona que engloben. A més de la reconversió d’aplicació monolítica cap a una arquitectura de microserveis, implementarem una nova funcionalitat que modificarà els límits de velocitat de les zones controlades per els sensors. Així doncs, en funció de les emissions que registren els sensors s’augmentarà o es disminuirà la velocitat dels carrers o trams de carretera que envolten les ciutats. Per al desenvolupament de la nostra proposta ens recolzarem amb Spring-boot una tecnologia que ens permet crear microserveis molt fàcilment i que funciona una capa per damunt del framework Spring, el descobridor de microserveis desenvolupat per Netflix anomenat Eureka i el broker RabbitMQ que ens permet implementar el protocol lleuger de missatgeria asíncrona MQTT i definir cues de treball asíncrones AMQP.[ES] En este trabajo expondremos una propuesta arquitectónica para convertir la arquitectura monolítica de ecoMobility a una solución orientada hacia los microservicios. Los objetivos de ecoMobility son la eficiencia energética y la reducción de emisiones de gases contaminantes provocados por el tráfico rodado que circula a través de las poblaciones. Para poder alcanzar estos objetivos ecoMobility tiene desplegada una red de sensores en diferentes zonas de Valencia, los cuales mediante gestores de mensajería envían la información hacia la aplicación monolítica encargada de transformar el mensaje recibido “en sucio” de los sensores y reenviar la información procesada hacia los diferentes servicios que gestionan el tráfico de la zona que engloban. Además de la reconversión de aplicación monolítica hacia una arquitectura de microservicios, implementaremos una nueva funcionalidad que modificará los límites de velocidad de las zonas controladas por los sensores. Así pues, en función de las emisiones que registren los sensores se aumentará o disminuirá la velocidad de las calles o de los tramos de carretera que existen alrededor de las ciudades. Para el desarrollo de nuestra propuesta nos apoyaremos en Spring-boot que es una tecnología que nos permite crear microservicios de forma sencilla y que funciona una capa por encima del framework Spring, el descubridor de microservicios desarrollado por Netflix llamado Eureka y el broker RabbitMQ que nos permite implementar el protocolo asíncrono de mensajería MQTT y definir colas de trabajo asíncronas AMQP.[EN] In this project we will present an architectural proposal to convert the monolithic architecture of ecoMobility into a microservices-oriented solution. The main objectives of ecoMobility are energy efficiency and reduction of polluting gases caused by traffic circulating in cities. To achieve these objectives, ecoMobility have distributed sensor networks in different areas of Valencia, these sensors through asynchronous messaging send messages that contains pollution information to the monolithic application which is on charge to process this information and forward the processed information to the different services that manage the traffic of the area that they cover. In addition to the conversion of the monolithic application to microservicesoriented solution, we implemented a new functionality that modifies the speed limits of the areas controlled by the sensors. Therefore, depending on the emissions recorded by the sensors, the speed of the streets or road sections that exist around the cities can be increased or decreased. For the development of our proposal, we have use Spring-boot, which is a technology that allows us to create microservices in a simple way, it works a layer above of the Spring framework, the microservices discover developed by Netflix called Eureka and the broker RabbitMQ which allow us to implement the light weight messaging protocol MQTT and define AMQP asynchronous work queues.Tallá Vivó, A. (2018). Disseny d’una solució basada en microserveis aplicada al projecte ecoMobility. http://hdl.handle.net/10251/110837TFG

Nieblas de otoño : (poesías originales)

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201

On the Exact Solution of a Class of Homogeneous Strongly Coupled Mixed Parabolic Problems

[EN] In this paper an exact series solution for homogeneous parabolic coupled systems is constructed using a projection method. An illustrative example is given.This work has been supported by Spanish Ministerio de Economía y Competitividad and the European Regional Development Fund (ERDF) TIN2014-59294-P.Defez Candel, E.; Soler Basauri, V.; Romero Vivó, S.; Verdoy González, JA. (2019). On the Exact Solution of a Class of Homogeneous Strongly Coupled Mixed Parabolic Problems. Filomat. 33(3):897-915. https://doi.org/10.2298/FIL1903897DS89791533

High incidence of chromosomal abnormalities in large-headed and multiple-tailed spermatozoa

Rodrigo Vivo, Lorena, [email protected] ; Prados Dodd, Nicolas, [email protected] ; Gil Salom, Manuel Luis, [email protected] ; Remohi Gimenez, Jose Alejandro, [email protected]

Programa Genérico de Evaluación

Se presenta un programa multimedia flexible para la gestión de una base de datos de conocimiento orientada a la (auto)evaluación. Se puede utilizar tanto en entorno de red como doméstico. Los contenidos multimedia son desarrollados mediante herramientas externas. Estos contenidos son referenciados desde la BD de conocimiento, pero no incluidos en ella. Soporta contextos sobre los que pueden realizarse preguntas y respuestas en diferentes medios, grados de dificultad y tipos (test, huecos, asociación,...). También jerarquiza los temas teóricos, asocia preguntas a contenidos teóricos multimedia y facilita la gestión del conocimiento por parte del profesor. Está abierto a cualquier tipo de docencia y nivel

Surveying a Sixteenth-Century Full-Scale Working Drawing. The Tracing for the Sail Vault at the Vestry of Murcia Cathedral

Full-scale tracings, drawn in plaster surfaces or engraved in stone walls and floors, were used frequently in Renaissance construction, in order to control the execution of ashlar masonry. In many occasions, these tracings furnished the shape of the templates used in the dressing process, either in true size or orthogonal projection. A large example of these tracings appeared in 2009 in the vestry of Murcia cathedral, when the sacristy drawers were disassembled in order to execute a conservation treatment against woodworm. At first sight, the tracing seemed to be related to the vault over the vestry, built in 1525 by Jacopo Torni l'Indaco, one of the first examples of ashlar sail vaults in Europe; a number of surveys confirmed that the tracing corresponds with the vault quite precisely. After an introductory section dealing with tracings and dressing techniques, the authors explain the measuring methods used in the surveys, describe the tracing, compare the tracing and the built vault, and discuss the relevance of the tracing for the history of dressing methods in European ashlar masonry.Colegio Oficial de Arquitectos de Murcia Deán y Cabildo de la Catedral de Murci

False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3

In this work, false positive rate of an arrayCGH platform for its use in day-3 single-blastomere analysis was calculated. For this purpose, 38 embryos diagnosed as abnormal on day-3 by FISH were re-biopsied on day-4. Single-cell day-4 arrayCGH diagnosis was then performed. A successful amplification was obtained in 97.4 % (37/38) of the day-4 cells analysed by arrayCGH. Day-3 FISH and day-4 arrayCGH diagnosis were concordant in 35/37 cases. The two discordant embryos were spread and all the cells from each embryo were re-analysed by FISH on day 5. The same error rate (2.7 %) for day-3 FISH and day-4 arrayCGH was obtained when comparing day-5 FISH re-analysis. After this pre-clinical phase, the platform was used for day-3 arrayCGH clinical application in 320 patients (1,760 embryos). Day-3 amplification rate was 98.6 %. An optimal reproductive outcome was obtained when applying arrayCGH to a clinical program: clinical pregnancy rate per cycle of 38.4 % and 60.3 % per transference were obtained, with an implantation rate of 53.5 %. Overall miscarriage rate was 10.6 %. Additionally, day-5 FISH re-analysis was performed in 42 of the embryos from the clinical phase, obtaining a concordance rate of 97.6 % with day-3 arrayCGH.Electronic supplementary materialThe online version of this article (doi:10.1007/s10815-012-9918-4) contains supplementary material, which is available to authorized users

The genomic history of the Iberian Peninsula over the past 8000 years

We assembled genome-wide data from 271 ancient Iberians, of whom 176 are from the largely unsampled period after 2000 BCE, thereby providing a high-resolution time transect of the Iberian Peninsula.We document high genetic substructure between northwestern and southeastern hunter-gatherers before the spread of farming.We reveal sporadic contacts between Iberia and North Africa by ~2500 BCE and, by ~2000 BCE, the replacement of 40% of Iberia's ancestry and nearly 100% of its Y-chromosomes by people with Steppe ancestry.We show that, in the Iron Age, Steppe ancestry had spread not only into Indo-European-speaking regions but also into non-Indo-European-speaking ones, and we reveal that present-day Basques are best described as a typical Iron Age population without the admixture events that later affected the rest of Iberia. Additionally, we document how, beginning at least in the Roman period, the ancestry of the peninsula was transformed by gene flow from North Africa and the eastern Mediterranean

Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease : A Multicentre Study of Geteccu

Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered "exposed". The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2-2.0), urgent surgery (OR: 1.6; 95% CI: 1.2-2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1-1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3-2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97-1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03-2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections

Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu

Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered “exposed”. The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2–2.0), urgent surgery (OR: 1.6; 95% CI: 1.2–2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1–1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3–2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97–1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03–2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections