O cuidado com pessoas com deficiência em tempos do COVID-19: considerações acerca do tema/ Caring for people with disabilities in COVID-19 TIMES: considerations on the theme

Este artigo tem como objetivo suscitar uma reflexão acerca dos cuidados que as Pessoas com Deficiência têm por direito no enfretamento da pandemia do COVID- 19. Nasce de uma inquietação a partir de entrevistas de especialistas apresentadas nas redes sociais informativas da web do que os especialistas julgam ser grupo de risco para a COVID- 19 e seus protocolos de atendimento, assim como da análise das políticas públicas emergenciais a que todos supostamente têm o direito, mas que de fato não vem acontecendo. Este texto reflexivo na sua essência busca dialogar com alguns autores como Fernandes & Orrico (2016-2012); Castel (1987) & Santos (2020); além de análise de alguns dispositivos normativos editados em protocolos internacionais pelo governo federal

Analysis of the Effects of Technological and Organizational Features on Intranet and Portal Usage

The paper’s purpose is to analyze the effects of technological and organizational features on intranet and portal usage. Technological features comprise common intranet functions such as collaboration, search engine, personalization, workflow and content management. Intranet organizational features were associated with intranet support team’s profile, existence of specific budget for the intranet project and relationship with users. The research model was based on TAM, TTF and on several checklists from intranet literature. A survey was conducted with intranet managers from 98 Brazilian and 70 Portuguese organizations. Factor analysis revealed intranet integration features as a separate construct from technological features. The results showed that many analyzed intranets were at the basic stages. There was evidence that intranet integration and organizational features had more impact on intranet quality and usage than technological features

Predisposing factors for amputation of lower extremities in diabetic patients with foot ulceration in the state of Sergipe

OBJECTIVE: To determine the predisposing factors for amputation of lower limbs in diabetic patients with foot ulceration. METHODS: The research was carried out in hospitals, and all diabetic patients with foot ulceration were included. Amputation was studied in relation to age, sex, previous amputation, number of ulcers, time of diagnosis of diabetes mellitus, time of ulceration, average number of days in hospital, Wagner's classification, and presence of foot pulse. RESULTS: We verified that 55% (44/80) of the patients progressed to some type of amputation of the lower limbs; mean age was 61 years, but the occurrence of amputation was significantly higher in the age group between 60 and 90 years (P = 0.03). We did not observe a significant variation in the following variables: time of diagnosis of diabetes, time of ulceration, and hospitalization time in relation to the group of patients who were amputated. Nevertheless, the most severe lesions, when evaluated by Wagner's classification (P <0.001) and by the absence of both distal pulses (P <0.001) of lower limbs, turned out to be very significant in relation to the amputation outcome. CONCLUSION: The severity of lesions, the absence of pulse and age over 60 years were considered predisposing factors for amputation in these patients.OBJETIVO: Determinar os fatores predisponentes para a amputação de membros inferiores nos doentes internados com diabetes melito e úlceras nos pés. MÉTODOS: Foram acompanhados os pacientes diabéticos com úlceras nos pés internados no período de 6 meses e analisadas as amputações nesses doentes em relação à idade, sexo, amputação prévia, número de ulcerações, tempo de diagnóstico do diabete, tempo de ulceração, tempo médio de internação, gravidade das lesões, presença de pulso. RESULTADOS: Verificou-se que 55% (44/80) dos doentes evoluíram para algum tipo de amputação de membros inferiores; a mediana das idades foi de 61 anos, porém a ocorrência de amputação foi significativamente maior na faixa etária dos 60 aos 90 anos (P = 0,03). Não se observou uma variação significativa da mediana do tempo de diagnóstico do diabetes, do tempo de ulceração e do tempo médio de internação em relação ao grupo de pacientes que foram amputados. Entretanto, as lesões mais graves, quando avaliadas pela classificação de Wagner (P <0,001) e pela ausência de detecção dos dois pulsos distais (P <0,001) dos membros inferiores, revelaram-se bastante significativas com relação ao desfecho de amputação. CONCLUSÃO: Foram considerados fatores predisponentes para a ocorrência de amputação nesses doentes a gravidade das lesões, a ausência de pulsos e as idades acima de 60 anos.Universidade TiradentesUniversidade Federal de Sergipe Departamento de MedicinaFundação Universitária de Ciências da Saúde de Alagoas Departamento de Medicina SocialEscola de Ciências Médicas de Alagoas Fundação Universitária de Ciências da Saúde de Alagoas Departamento de Clínica CirúrgicaUniversidade Federal de São Paulo (UNIFESP) Departamento de CirurgiaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, Depto. de CirurgiaUNIFESP, EPMSciEL

The Lontras Shale (Permian, Paraná Basin) and its Fossils: Discovery, Taxonomic Identification and Present Knowledge

The Shaler Memorial Fund created in 1907 by students and admirers of the geologist Nathaniel Southgate Shaler, professor from Harvard University, allowed in its first contribution to fostering research, the organization of an expedition to the South and Southeast of Brazil. The expedition had the purpose to confirm Nathaniel`s ideas about the existence of glacial layers older then the Pleistocene. Led by the North American geologist Jay Backus Woodworthy and counting with participation of the Brazilian geologist Euzébio de Oliveira, the expedition not only proved the presence of glacial evidence but also discovered an intercalated fossiliferous marine shale, later known as Lontras Shale, Itararé Group. The fossils, initially studied by the American paleontologist Rudolf Ruedemann and by Euzébio de Oliveira, had its studies intensified from the 1980s with the identification of new outcrops and due the new data of the geological evolution of the carboniferous and permian sedimentary sucessions of the Paraná Basin. Economic disputes and discussion about the preservation of Lontras Shale outcrops, besides the discovered of new site namely as CAMPÁLEO, have reactivated the scientific interest about this unit and its paleontological content, increasing its studies. Poorly known by the Brazilian academic community, the historical context of the Lontras Shale is here reported, highlighting the importance of the Shale Memorial Fund as responsible for the geological and paleontological discoveries that have followed, for more than a century

The cost of type 1 diabetes: a nationwide multicentre study in Brazil

Objective To determine the direct medical costs of type 1 diabetes mellitus (T1DM) to the National Brazilian Health-Care System (NBHCS) and quantify the contribution of each individual component to the total cost.Methods A retrospective, cross-sectional, nationwide multicentre study was conducted between 2008 and 2010 in 28 public clinics in 20 Brazilian cities. the study included 3180 patients with T1DM (mean age 22 year's +/- 11.8) who were surveyed while receiving health care from the NBHCS. the mean duration of their diabetes was 10.3 years (+/- 8.0). the costs of tests and medical procedures, insulin pumps, and supplies for administration, and supplies for self-monitoring of blood glucose (SMBG) were obtained from national and local health system sources for 2010-2011. Annual direct medical costs were derived by adding the costs of medications, supplies, tests, medical consultations, procedures and hospitalizations over the year preceding the interview.Findings the average annual direct medical cost per capita was 1319.15 United States dollars (US$). Treatment-related expenditure - US$ 1216.33 per patient per year represented 92.20% of total direct medical costs. Insulin administration supplies and SMBG (US$696.78 per patient per year) accounted for 52.82$ 75.64 per patient per year) of direct medical costs. Consultations accounted for 1.94% of direct medical costs (US$ 25.62 per patient per year).Conclusion Health technologies accounted for most direct medical costs of T1DM. These data can serve to reassess the distribution of resources for managing T1DM in Brazil's public health-care system.Farmanguinhos/Fundacao Oswaldo Cruz/National Health MinistryBrazilian Diabetes SocietyFundacao do Amparo a Pesquisa do Estado do Rio de JaneiroConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)State Univ Hosp Rio de Janeiro, BR-20551030 Rio de Janeiro, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilBauru Diabet Assoc, Bauru, BrazilJoinville Endocrinol & Diabet Inst, Joinville, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc

A structure-based site-directed mutagenesis study on the neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) catalysis

Neurolysin (EP24.16) and thimet oligopeptidase (EP24.15) are closely related metalloendopeptidases. Site-directed mutagenesis of Tyr(613) (EP24.16) or Tyr(612) (EP24.15) to either Phe or Ala promoted a strong reduction of k(cat)/K-M for both enzymes. These data suggest the importance of both hydroxyl group and aromatic ring at this specific position during substrate hydrolysis by these peptidases. Furthermore, the EP24.15 A607G mutant showed a k(cat)/K-M of 2x10(5) M-1 s(-1) for the Abz-GFSIFRQ-EDDnp substrate, similar to that of EP24.16 (k(cat)/K-M = 3x10(5) M-1 s(-1)) which contains Gly at the corresponding position; the wild type EP24.15 has a k(cat)/K-M of 2.5x10(4) M-1 s(-1) for this substrate. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.Univ Mogi das Cruzes, CIIB, BR-08780911 Mogi Das Cruzes, SP, BrazilInst Butantan, CAT, Ctr Toxicol Aplicada, BR-05467010 São Paulo, BrazilUniv São Paulo, Inst Ciencias Biomed, Program Biol Celular, Dept Histol & Embriol, BR-05508900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biofis, BR-04044020 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biofis, BR-04044020 São Paulo, BrazilWeb of Scienc

Hematologia de tilápias‑do‑nilo alimentadas com dietas com óleos vegetais e estimuladas pelo frio

The objective of this work was to evaluate the effect of diets with different omega-6 and omega-3 polyunsaturated fatty acid ratios on the hematological parameters and plasma lipids of Nile tilapia before and after cold stress. A total of 320 tilapia juveniles sex-inverted males (±7.50 g) were randomly distributed into 40 tanks (250 L) and feed with eight diets: basal (without oil supplementation), 6% sunflower oil (SO), 5% SO + 1% linseed oil (LO), 4% SO + 2% LO, 3% SO + 3% LO, 2% SO + 4% LO, 1% SO + 5% LO, and 6% LO. Hematological parameters and plasma lipids were evaluated 85 days after cultivation and three days after cold stress. Diets had no effect on any of the analyzed variables before cold stress. The number of leukocytes decreased in fish fed the 6% LO diet, after cold stress. Cold stress worsened fish health, causing leukopoenia. Nile tilapia fed 6% LO diet presented less resistance to cold.O objetivo deste trabalho foi avaliar os efeitos de dietas com diferentes relações entre ácidos graxos poliinsaturados ômega-6 e ômega-3 nos parâmetros hematológicos e lipídeos plasmáticos de tilápias-do-nilo, antes e após estímulo pelo frio. Foram utilizados 320 alevinos invertidos para macho (±7,5 g), distribuídos aleatoriamente em 40 tanques (250 L) e alimentados com oito dietas: basal (sem adição de óleo), 6% de óleo de girassol (OG), 5% de OG + 1% de óleo de linhaça (OL), 4% de OG + 2% OL, 3% de OG + 3% de OL, 2% de OG + 4% de OL, 1% de OG + 5% de OL e 6% de OL. Os parâmetros hematológicos e os lipídeos plasmáticos foram determinados ao final de 85 dias de cultivo e após três dias de estímulo pelo frio. Não houve efeito das dietas sobre nenhuma das variáveis analisadas no período anterior ao estímulo. O número de leucócitos foi reduzido em peixes alimentados com a dieta 6% de OL, após estímulo pelo frio. O estímulo pelo frio provocou um declínio do estado geral de saúde, como leucopenia. Tilápias-do-nilo alimentadas com dietas com 6% de OL apresentaram menor resistência ao frio

Comparison of Fetal Nuchal Fold Thickness Measurements by Two- and Three-Dimensional Ultrasonography (3DXI Multislice View)

Purpose. To compare the measurements of fetal nuchal fold (NF) thickness by two-dimensional (2D) and three-dimensional (3D) ultrasonography using the three-dimensional extended imaging (3DXI). Methods. A cross-sectional study was performed with 60 healthy pregnant women with a gestational age between 16 and 20 weeks and 6 days. The 2D-NF measurements were made as the distance from the outer skull bone to the outer skin surface in the transverse axial image in the suboccipital-bregmatic plane of the head. For the 3D we employed the 3DXI multislice view software, in which 3 × 2 tomographic planes was displayed on the screen and the distance between the tomographic slices was 0.5 mm. Maximum, minimum, mean, and standard deviation were calculated for 2D and 3D ultrasonography, as well the maximum and minimum, mean, and standard deviation for the difference between both methods. The Wilcoxon signed-rank test was used to compare the two different techniques. Results. 2D-NF showed a mean of thickness of 3.52 ± 0.95 mm (1.69–7.14). The mean of 3D-NF was 3.90 ± 1.02 mm (2.13–7.72). The mean difference between the methods was 0.38 mm, with a maximum difference of 3.12 mm. Conclusion. The NF thickness measurements obtained by 3D ultrasonography were significantly larger than those detected with 2D ultrasonography