4 research outputs found
HDAC1 links early life stress to schizophrenia-like phenotypes.
Significance
Early life stress (ELS) is an important risk factor for schizophrenia. Our study shows that ELS in mice increases the levels of histone-deacetylase (HDAC) 1 in brain and blood. Although altered
Hdac1
expression in response to ELS is widespread, increased
Hdac1
levels in the prefrontal cortex are responsible for the development of schizophrenia-like phenotypes. In turn, administration of an HDAC inhibitor ameliorates ELS-induced schizophrenia-like phenotypes. We also show that
Hdac1
levels are increased in the brains of patients with schizophrenia and in blood from patients who suffered from ELS, suggesting that the analysis of
Hdac1
expression in blood could be used for patient stratification and individualized therapy.
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