Evaluation of Ischemic Stroke Hybrid Segmentation in a Rat Model of Temporary Middle Cerebral Artery Occlusion using Ground Truth from Histologic and MR data

A segmentation method that quantifies cerebral infarct using rat data with ischemic stroke is evaluated using ground truth from histologic and MR data. To demonstrate alternative approach to rapid quantification of cerebral infarct volumes using histologic stained slices that requires scarifying animal life, a study with MR acquire volumetric rat data is proposed where ground truth is obtained by manual delineations by experts and automated segmentation is assessed for accuracy. A framework for evaluation of segmentation is used that provides more detailed accuracy measurements than mere cerebral infarct volume. Our preliminary experiment shows that ground truth derived from MRI data is at least as good as the one obtained from the histologic slices for evaluating segmentation algorithms for accuracy. Therefore we can develop and evaluate automated segmentation methods for rapid quantification of stroke without the necessitating animal sacrifice

Ground Truth for Evaluation of Ischemic Stroke Hybrid Segmentation in a Rat Model of Temporary Middle Cerebral Artery Occlusion

In vivo rodent models of focal cerebral ischemia have been developed to investigate stroke therapy. Typically these models require rapid quantification of cerebral infarct volumes using vital stains with tetrazolium salts to delineate the extent of neuronal death. To avoid animal sacrifice, we sought a study with MR acquired volumetric rata data where surrogate of ground truth is obtained by repeated manual delineation by experts, and an automated hybrid segmentation is evaluated for accuracy. We propose a rating system for the expert delineations that captures intra- and inter-expert discrepancy. Our preliminary results show that surrogate ground truth derived from MR data is at least as good as the one derived from histologic stained slices. Hence animal sacrifice is not necessary to evaluate ischemic stroke automated segmentation in a rat model of temporary middle cerebral artery occlusion

Placemaking from Interstitial Spaces: Participatory planning and collaborative community design as strategies to revitalize a service alleyway in Montreal (Bishop/Mackay)

This project explores participatory planning and community design methodologies (i.e. pattern language design, placemaking, community planning charrettes, planning-in-situ, open planning and peer to peer urbanism) to revitalize a service alleyway in downtown Montreal. The objective of this project is to democratize planning and urban design practices and to engage ordinary citizens in the planning of their own spaces. After a series of visioning workshops, brainstorming sessions and a community planning charrette, this project incorporates inputs from stakeholders, students and ordinary citizens into a collaborative urban design project. The project proposes interventions such as a woonerf, a planning committee, a cubic/fractal scaffolding structure, art murals and wall projections (among others). With the objective of encouraging future adaptations and transformations, this project is published under a Creative Commons license. Adopt and adapt these ideas (but cite and acknowledge accordingly)

The nature of Hart Crane’s vision : a study of White buildings

Note:This thesis is a detailed, thematic study of Hart Crane's first book of poetry, White Buildings. This volume has commonly been thought to lack a significant theme and to be haphazardly organized. My thesis is that White Buildings does have a major, pervasive theme: the 'irreconcilable tension between those moments of illumination known as "vision" and the restrictions of everyday reality (the human condition). This dual awareness was basic to Crane's sensibility and is the dominant concern of White Buildings. I have argued as well that ~-~bite Buildings is not merely a randomly arranged collection of poems, but that Crane carefully and purposefully organized it in terms of a progressive strengthening of the poetic role. Finally, in order to elucidate this poetry, I have pointed at the many parallels that exist between his personal "vision" and a well-established philosophic (Plato, Nietzsche, Emerson) and poetic (Blake, Keats, Whitman, etc.) visionary tradition. It becomes clear that Crane was not an undisciplined, poorly read poet (as is generally believed), but that he responded sensitively and creatively to these artists, and this is reflected throughout White Buildings.Cette thèse étudie en plénitude le premier ouvrage du poète Hart Crane s'intitulant White Buildings. Ce volume fut cru par plusieurs comma étant dépourvu et d’un thème significative et d'une organisation logique. Je soutiens au contraire que White Buildings contient un thème principale - celle de la tension incoinçable entre les moments d'imagination illuminée connus comme la "vision" et les restrictions de la réalité quotidienne (la condition humaine). Cette double conscience rut fondamentale à la sensibilité de Crane et je constate qu’elle est la préoccupation dominante de son ouvrage. Aussi, j'argue que White Buildings n'est pas une simple collection de poèmes disposées à l'arbitraire, mais que Crane l'a soucieusement et intentionnellement organisé en fonction d'un renforcement graduel du rôle poétique. Finalement, en fin d’élucider cette poésie, je fais observer les diverses comparaisons existantes entre sa "vision" personnelle et une tradition visionnaire bien établie, soit de nature philosophique (Plato, Nietzsche, Emerson), soit de nature poétique (Blake, Keats, Whitman, etc.). [...

The 1,3-rearrangement Of Ortho-amino Phenylcarbinols.

PhDOrganic chemistryUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/182577/2/5904987.pd