The ethanol extract of Euphorbia hirta exhibits in vitro antidiabetic potentials by sensitization of the insulin

The objective of current investigation was to assess the mechanism of action of Euphorbia hirta for its antidiabetic properties. Materials &Methods: The authenticated leaves of plant Euphorbia hirta were dried and powdered. The powdered drug was defatted with petroleum ether and subjected to ethanol extraction. The ethanol extract of Euphorbia hirta was subjected to preliminary phytochemical investigation. The glucose up takes by rat hemi-diaphragm (skeletal muscle) model was also used evaluate potentials of the ethanol extract of Euphorbia hirta to enhance utilization of the blood glucose by peripheral tissues. The overnight fasted albino rat was sacrificed and dissected to hemidiaphragm. Weighed quantity of skeletal muscle was incubated with glucose in Tyrode solution for 30 mins at 37oC and the amount of glucose utilized by the tissue was determined. Results: The ethanol extract of Euphorbia hirta significantly increased the glucose utilization by skeletal muscle which its shows potency to sensitize the insulin. Conclusion: The results of the presents investigation recommends that, one of the mechanisms of ethanol extract of Euphorbia hirta for antidiabetic activity is reduction of insulin resistance