Environmental enteropathy in undernourished Pakistani children: Clinical and histomorphometric analyses

Despite nutrition interventions, stunting thought to be secondary to underlying environmental enteropathy (EE) remains pervasive among infants residing in resource-poor countries and remains poorly characterized. From a birth cohort of 380 children, 65 malnourished infants received 12 weeks of nutritional supplementation with ready-to-use therapeutic food (RUTF). Eleven children with insufficient response to RUTF underwent upper endoscopy with duodenal biopsies, which were compared with U.S., age-matched specimens for healthy, celiac disease, non-celiac villous atrophy, non-celiac intraepithelial lymphocytosis, and graft-versus-host disease patients. Of the 11 children biopsied, EE was found in 10 (91%) with one subject with celiac disease. Morphometry demonstrated decreased villus-to-crypt (V:C) ratios in EE relative to healthy and non-celiac lymphocytosis patients. Environmental enteropathy villus volumes were significantly decreased relative to healthy controls. In EE, average CD3+ cells per 100 epithelial cells and per 1,000 µm2 of lamina propria and the number of lamina propria CD20+ B-cell aggregates were increased relative to all other groups. Our results indicate that V:C ratios are reduced in EE but are less severe than in celiac disease. Environmental enteropathy intraepithelial and lamina propria T lymphocytosis is of greater magnitude than that in celiac disease. The increases in lamina propria B and T lymphocytes suggest that non-cytolytic lymphocytic activation may be a more prominent feature of EE relative to celiac disease. These results provide new insights into shared yet distinct histological and immunological features of EE and celiac disease in children

One-to-many-relations in morphology, syntax, and semantics

The standard view of the form-meaning interfaces, as embraced by the great majority of contemporary grammatical frameworks, consists in the assumption that meaning can be associated with grammatical form in a one-to-one correspondence. Under this view, composition is quite straightforward, involving concatenation of form, paired with functional application in meaning. In this book, we discuss linguistic phenomena across several grammatical sub-modules (morphology, syntax, semantics) that apparently pose a problem to the standard view, mapping out the potential for deviation from the ideal of one-to-one correspondences, and develop formal accounts of the range of phenomena. We argue that a constraint-based perspective is particularly apt to accommodate deviations from one-to-many correspondences, as it allows us to impose constraints on full structures (such as a complete word or the interpretation of a full sentence) instead of deriving such structures step by step. Most of the papers in this volume are formulated in a particular constraint-based grammar framework, Head-driven Phrase Structure Grammar. The contributions investigate how the lexical and constructional aspects of this theory can be combined to provide an answer to this question across different linguistic sub-theories

One-to-many-relations in morphology, syntax, and semantics

The standard view of the form-meaning interfaces, as embraced by the great majority of contemporary grammatical frameworks, consists in the assumption that meaning can be associated with grammatical form in a one-to-one correspondence. Under this view, composition is quite straightforward, involving concatenation of form, paired with functional application in meaning. In this book, we discuss linguistic phenomena across several grammatical sub-modules (morphology, syntax, semantics) that apparently pose a problem to the standard view, mapping out the potential for deviation from the ideal of one-to-one correspondences, and develop formal accounts of the range of phenomena. We argue that a constraint-based perspective is particularly apt to accommodate deviations from one-to-many correspondences, as it allows us to impose constraints on full structures (such as a complete word or the interpretation of a full sentence) instead of deriving such structures step by step. Most of the papers in this volume are formulated in a particular constraint-based grammar framework, Head-driven Phrase Structure Grammar. The contributions investigate how the lexical and constructional aspects of this theory can be combined to provide an answer to this question across different linguistic sub-theories

One-to-many-relations in morphology, syntax, and semantics

The standard view of the form-meaning interfaces, as embraced by the great majority of contemporary grammatical frameworks, consists in the assumption that meaning can be associated with grammatical form in a one-to-one correspondence. Under this view, composition is quite straightforward, involving concatenation of form, paired with functional application in meaning. In this book, we discuss linguistic phenomena across several grammatical sub-modules (morphology, syntax, semantics) that apparently pose a problem to the standard view, mapping out the potential for deviation from the ideal of one-to-one correspondences, and develop formal accounts of the range of phenomena. We argue that a constraint-based perspective is particularly apt to accommodate deviations from one-to-many correspondences, as it allows us to impose constraints on full structures (such as a complete word or the interpretation of a full sentence) instead of deriving such structures step by step. Most of the papers in this volume are formulated in a particular constraint-based grammar framework, Head-driven Phrase Structure Grammar. The contributions investigate how the lexical and constructional aspects of this theory can be combined to provide an answer to this question across different linguistic sub-theories

One-to-many-relations in morphology, syntax, and semantics

The standard view of the form-meaning interfaces, as embraced by the great majority of contemporary grammatical frameworks, consists in the assumption that meaning can be associated with grammatical form in a one-to-one correspondence. Under this view, composition is quite straightforward, involving concatenation of form, paired with functional application in meaning. In this book, we discuss linguistic phenomena across several grammatical sub-modules (morphology, syntax, semantics) that apparently pose a problem to the standard view, mapping out the potential for deviation from the ideal of one-to-one correspondences, and develop formal accounts of the range of phenomena. We argue that a constraint-based perspective is particularly apt to accommodate deviations from one-to-many correspondences, as it allows us to impose constraints on full structures (such as a complete word or the interpretation of a full sentence) instead of deriving such structures step by step. Most of the papers in this volume are formulated in a particular constraint-based grammar framework, Head-driven Phrase Structure Grammar. The contributions investigate how the lexical and constructional aspects of this theory can be combined to provide an answer to this question across different linguistic sub-theories

One-to-many-relations in morphology, syntax, and semantics

The standard view of the form-meaning interfaces, as embraced by the great majority of contemporary grammatical frameworks, consists in the assumption that meaning can be associated with grammatical form in a one-to-one correspondence. Under this view, composition is quite straightforward, involving concatenation of form, paired with functional application in meaning. In this book, we discuss linguistic phenomena across several grammatical sub-modules (morphology, syntax, semantics) that apparently pose a problem to the standard view, mapping out the potential for deviation from the ideal of one-to-one correspondences, and develop formal accounts of the range of phenomena. We argue that a constraint-based perspective is particularly apt to accommodate deviations from one-to-many correspondences, as it allows us to impose constraints on full structures (such as a complete word or the interpretation of a full sentence) instead of deriving such structures step by step. Most of the papers in this volume are formulated in a particular constraint-based grammar framework, Head-driven Phrase Structure Grammar. The contributions investigate how the lexical and constructional aspects of this theory can be combined to provide an answer to this question across different linguistic sub-theories

One-to-many-relations in morphology, syntax, and semantics

The standard view of the form-meaning interfaces, as embraced by the great majority of contemporary grammatical frameworks, consists in the assumption that meaning can be associated with grammatical form in a one-to-one correspondence. Under this view, composition is quite straightforward, involving concatenation of form, paired with functional application in meaning. In this book, we discuss linguistic phenomena across several grammatical sub-modules (morphology, syntax, semantics) that apparently pose a problem to the standard view, mapping out the potential for deviation from the ideal of one-to-one correspondences, and develop formal accounts of the range of phenomena. We argue that a constraint-based perspective is particularly apt to accommodate deviations from one-to-many correspondences, as it allows us to impose constraints on full structures (such as a complete word or the interpretation of a full sentence) instead of deriving such structures step by step. Most of the papers in this volume are formulated in a particular constraint-based grammar framework, Head-driven Phrase Structure Grammar. The contributions investigate how the lexical and constructional aspects of this theory can be combined to provide an answer to this question across different linguistic sub-theories

One-to-many-relations in morphology, syntax, and semantics

The standard view of the form-meaning interfaces, as embraced by the great majority of contemporary grammatical frameworks, consists in the assumption that meaning can be associated with grammatical form in a one-to-one correspondence. Under this view, composition is quite straightforward, involving concatenation of form, paired with functional application in meaning. In this book, we discuss linguistic phenomena across several grammatical sub-modules (morphology, syntax, semantics) that apparently pose a problem to the standard view, mapping out the potential for deviation from the ideal of one-to-one correspondences, and develop formal accounts of the range of phenomena. We argue that a constraint-based perspective is particularly apt to accommodate deviations from one-to-many correspondences, as it allows us to impose constraints on full structures (such as a complete word or the interpretation of a full sentence) instead of deriving such structures step by step. Most of the papers in this volume are formulated in a particular constraint-based grammar framework, Head-driven Phrase Structure Grammar. The contributions investigate how the lexical and constructional aspects of this theory can be combined to provide an answer to this question across different linguistic sub-theories

One-to-many-relations in morphology, syntax, and semantics

The standard view of the form-meaning interfaces, as embraced by the great majority of contemporary grammatical frameworks, consists in the assumption that meaning can be associated with grammatical form in a one-to-one correspondence. Under this view, composition is quite straightforward, involving concatenation of form, paired with functional application in meaning. In this book, we discuss linguistic phenomena across several grammatical sub-modules (morphology, syntax, semantics) that apparently pose a problem to the standard view, mapping out the potential for deviation from the ideal of one-to-one correspondences, and develop formal accounts of the range of phenomena. We argue that a constraint-based perspective is particularly apt to accommodate deviations from one-to-many correspondences, as it allows us to impose constraints on full structures (such as a complete word or the interpretation of a full sentence) instead of deriving such structures step by step. Most of the papers in this volume are formulated in a particular constraint-based grammar framework, Head-driven Phrase Structure Grammar. The contributions investigate how the lexical and constructional aspects of this theory can be combined to provide an answer to this question across different linguistic sub-theories