Apesar de você, a poética do riso na dança : o risível cênico-coreográfico a partir da Macarenando Dance Concept

O presente estudo tem como propósito investigar a poética do riso na dança a partir de composição coreográfica em dança. No referencial teórico entre o riso e a dança há uma escassez de material escrito. Portanto, neste trabalho, foram utilizados autoras e autores clássicos do campo do risível e autorus contemporâneos do campo da dança e do humor. Há uma relevância (política e econômica) realizar um estudo a partir de uma pesquisa de observação e participação em um grupo e empreendimento cultural local da cidade de Porto Alegre – Macarenando Dance Concept e seu procedimento-cênico: Dance a Letra. Ao abrir camadas de significação através da Etnometodologia e da escritura, identificar os elementos do risível e trazer essa discussão produz que o trabalho possa auxiliar criações diversas, além da produção de conhecimento sobre o assunto. Compreendendo a relação da pesquisadora e pesquisades no contexto criando uma rede de significado e espaço para todas as vozes, identificando os elementos da poética do riso na criação em dança na trajetória do grupo, pois é um de seus traços poéticos, e na coreografia criada pela artistapesquisadora que teceu a trama cênica-coreográfica do espetáculo Sobrevida que ocorreu em 2016. Conclui-se abrindo em linhas de fuga, pois a poética pode criar derivas já que o processo criativo não se finaliza, mas tem intervalos e é ativo na produção de sentidos.The present study investigate a poetics of laughter in dance, based on dance choreographic composition. In the theoretical framework between laughter and dance, there is a shortage of written material, therefore, classic authors from the field of the laughable and contemporary authors from the field of dance and humor were used. There is a research (political and economic) to carry out a study, from a research of observation and participation in a group and local cultural enterprise of the city of Porto Alegre - Macarenando Dance Concept and they scenic-procedure: Dance a Letra. When opening layers of meaning through Ethnomethodology and writing, identifying the elements of the laughable and bringing this discussion produces that the work can help different creations, in addition to the production of knowledge on the subject. Understanding the relationship between the researcher and those researched in the context creating a network of meaning and space for all voices. Identifying the elements of the poetics of laughter in dance creation in the group's trajectory, it is one of they traits, and in the choreography created by the artist-researcher who wove the scenic-choreographic plot of the show Sobrevida that took place in 2018. It concludes by opening in lines of flight, as poetics can create drifts since the creative process does not end, but has intervals and is active in the production of meanings

Em algum lugar do corpo se inscreve um nome : experimentações dramatúrgicas em dança com possíveis representatividades LgBTqiaP+

O presente trabalho busca criar dramaturgicamente em dança abrangendo possíveis representatividades LgBTqiaP+, nos contextos de Porto Alegre e Canoas - RS/Brasil, em dois experimentos: em algum lugar do corpo se inscreve e Diz o nome. Compreende-se a potência do campo da Dança nas criações e autoria dos corpos, contudo percebe-se a ausência de discursos pertencentes à comunidade LgBTqiaP+ em cena. Para se relacionar com os materiais da pesquisa e o tema, utiliza-se da metodologia cartográfica, incluindo as etapas de rastreio, toque, pouso e reconhecimento. Assim, mapeia-se espaços agentes da dança, na cidade de Porto Alegre, reflete-se sobre conceitos de representatividade, representação, dramaturgia e termos que condizem a comunidade LgBTqiaP+ e cria-se dramaturgias em dança com em algum lugar do corpo se inscreve e Diz o nome, projeto financiado pelo Programa de Incentivo à Cultura de Canoas e com apoio do SESC Canoas. A fim de criar um espaço em que a representação tenha um possível efeito de representatividade, um dos caminhos encontrados foi apostar no trabalho da dramaturgia da dança e reconhecer as autorias das pessoas que estão criando a obra artística, buscando construir espaços não apenas possíveis, mas seguros e acolhedores para as criações em dança.This work aims to create dramaturgically in dance, encompassing possible LgBTqiaP+ representations in the contexts of Porto Alegre and Canoas - RS/Brazil, through two experiments: Somewhere in the Body is Inscribed and Say the Name. The potential of the dance field in the creations and authorship of bodies is understood, but there is a noticeable absence of LgBTqiaP+ community discourses on stage. To engage with the research materials and the theme, a cartographic methodology is employed, including stages of tracing, touch, landing, and recognition, in order to map dance agent spaces in the city of Porto Alegre, reflect on concepts of representation, dramaturgy, and terms related to the LgBTqiaP+ community, and create dramaturgies in dance with Somewhere in the Body is Inscribed and Say the Name, a project funded by Canoas Cultural Incentive Program and supported by SESC Canoas. In order to create a space where representation has a possible effect of representativeness, one of the paths found was to invest in the work of dance dramaturgy and recognize the authorship of the people who are creating the artistic work, seeking to build spaces that are not only possible but also safe and welcoming for dance creations

Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study

<p>Abstract</p> <p>Background</p> <p>The prebiotic potential of lactulose is well established and preclinical studies demonstrated a protective effect of lactulose in murine models of colitis. The aim of the present study was to investigate the clinical and histological efficacy of lactulose in patients with inflammatory bowel disease (IBD), for which probiotic therapy yielded promising results.</p> <p>Methods</p> <p>Patients were treated with standard medication alone or combined with 10 g lactulose daily as adjuvant therapy for 4 months. Clinical efficacy of treatment was assessed using clinical activity indices, a quality of life index (IBDQ), endoscopic scores, defecation frequency and monitoring corticosteroid medication. Orsomucoid, alpha1-antitrypsin and other laboratory parameters were determined. In addition, in some participants colonic biopsies were analyzed with haematoxylin-eosin staining or with antibodies against HLA-DR, CD68, IgA and CD3, and evaluated systematically. All measurements were performed both at enrolment and at the end of the trial.</p> <p>Results</p> <p>14 patients presenting ulcerative colitis (UC) and 17 patients presenting Crohn's disease (CD), most of them in a clinically active state, were enrolled in this pilot study. After 4 month no significant improvement of clinical activity index, endoscopic score or immunohistochemical parameters was observed in CD or UC patients receiving lactulose in comparison to the control group. However, significant improvement of quality of life was observed in UC patients receiving lactulose compared to the control group (p = 0.04).</p> <p>Conclusion</p> <p>The findings of the present pilot study indicate that oral lactulose has no beneficial effects in IBD patients in particular with regard to clinical activity, endoscopic score or immunohistochemical parameters. The importance of the beneficial effect of lactulose in UC patients regarding the quality of life needs further evaluation in larger controlled clinical trials.</p> <p>Trial registration</p> <p>Current Controlled Trials ISRCTN92101486</p

Carotid artery volumetric measures associate with clinical ten-year cardiovascular (CV) risk scores and individual traditional CV risk factors in rheumatoid arthritis; a carotid-MRI feasibility study

Background: Common carotid artery intima-media thickness (CIMT), as measured by ultrasound, has utility in stratification of the accelerated cardiovascular risk seen in rheumatoid arthritis (RA); however, the technique has limitations. Carotid magnetic resonance imaging (MRI) is emerging as a useful research tool in the general population, but has yet to be applied in RA populations. Our objectives were to describe the utility of carotid artery MRI (carotid-MRI) in patients with RA in comparison to healthy controls and to describe the association with RA disease phenotype. Methods: Sixty-four patients with RA and no history of cardiovascular (CV) disease/diabetes mellitus were assessed for RA and CV profile, including homeostasis model assessment-estimated insulin resistance (HOMA-IR) and N-terminal pro-brain natriuretic peptide (NT-proBNP). All underwent carotid-MRI (3 T), and were compared to 24 healthy controls. Univariable analysis (UVA) and multivariable linear regression models (MVA) were used to determine associations between disease phenotype and carotid-MRI measures. Results: There were no significant differences in carotid arterial wall measurements between patients with RA and controls. Wall and luminal volume correlated with 10-year CV risk scores (adjusted as per 2017 European League Against Rheumatism (EULAR) guidance); rho = 0.33 (p = 0.012) and rho = 0.35 (p = 0.008), respectively, for Joint British Societies-2 risk score. In UVA, carotid-MRI volumetric measures predominantly were associated with traditional CV risk factors including age, ever-smoking and HOMA-IR (p < 0.05). Lower body mass index was associated with wall maximum thickness (r = − 0.25 p = 0.026). In MVA, age was independently associated with wall volume (B 1.13 (95% CI 0.32, 1.93), p = 0.007) and luminal volume (B 3.69 (95% CI 0.55, 6.83, p = 0.022), and RA disease duration was associated with luminal volume (B 3.88 (95% CI 0.80, 6.97), p = 0.015). Conclusions: This study demonstrates the utility of carotid-MRI in RA, reporting an association between three-dimensional measures in particular and CV risk scores, individual traditional CV risk factors and RA disease duration. Carotid-MRI in RA is a promising research tool in the investigation of CVD

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p&lt;0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p&lt;0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p&lt;0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP &gt;5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification