Effects of Feeding Level and Diet Energy Density on Cattle Exposed to Heat

Under hot environment conditions, individually fed steers maintained lower body temperatures and grater intakes when limit fed when compared to steers fed the same diet ad libitum

Die Situation der Generika in der Schweiz

Die Ärzte verschreiben mehr Generika und die Apotheker machen häufiger von ihrem Substitutionsrecht Gebrauch. Trotzdem behalten die Originalpräparate einen wichtigen Platz. [Hrsg.]]]> Drugs, Generic ; Managed Care Programs ger oai:serval.unil.ch:BIB_F16FA56C34D4 2022-05-07T01:29:53Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_F16FA56C34D4 Ovine microsatellites at the OarHH35, OarHH41, OarHH44, OarHH47 and OarHH64 loci info:doi:10.1111/j.1365-2052.1993.tb00300.x info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2052.1993.tb00300.x info:eu-repo/semantics/altIdentifier/pmid/8363109 Henry, H. M. Penty, J. M. Pierson, C. A. Crawford, A. M. info:eu-repo/semantics/article article 1993-06 Animal Genetics, vol. 24, no. 3, pp. 222 info:eu-repo/semantics/altIdentifier/pissn/0268-9146 Alleles Animals Base Sequence DNA, Satellite/*chemistry Gene Frequency Gene Library Molecular Sequence Data Polymerase Chain Reaction/veterinary Repetitive Sequences, Nucleic Acid Sheep/*genetics oai:serval.unil.ch:BIB_F1707A8BA422 2022-05-07T01:29:53Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_F1707A8BA422 Sudden paraplegia due to an anterior spinal artery syndrome during the course of Staphylococcus aureus septicemia. info:doi:10.1159/000106514 info:eu-repo/semantics/altIdentifier/doi/10.1159/000106514 info:eu-repo/semantics/altIdentifier/pmid/17675832 Pantet, O. Frischknecht, R. Croquelois, A. info:eu-repo/semantics/article article 2007 Cerebrovascular Diseases, vol. 24, no. 2-3, pp. 307-309 info:eu-repo/semantics/altIdentifier/pissn/1015-9770 urn:issn:1015-9770 Anterior Spinal Artery Syndrome/complications; Anterior Spinal Artery Syndrome/microbiology; Anti-Infective Agents/therapeutic use; Combined Modality Therapy; Decompression, Surgical; Drainage; Epidural Abscess/complications; Epidural Abscess/microbiology; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Paraplegia/microbiology; Paraplegia/pathology; Sepsis/complications; Sepsis/microbiology; Spinal Cord Compression/complications; Spinal Cord Compression/microbiology; Staphylococcus aureus/isolation &amp; purification; Treatment Outcome eng oai:serval.unil.ch:BIB_F170F432E72A 2022-05-07T01:29:53Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_F170F432E72A Development and Clinical Validation of a Blood Test Based on 29-Gene Expression for Early Detection of Colorectal Cancer. info:doi:10.1158/1078-0432.CCR-15-2057 info:eu-repo/semantics/altIdentifier/doi/10.1158/1078-0432.CCR-15-2057 info:eu-repo/semantics/altIdentifier/pmid/27126992 Ciarloni, L. Ehrensberger, S.H. Imaizumi, N. Monnier-Benoit, S. Nichita, C. Myung, S.J. Kim, J.S. Song, S.Y. Kim, T.I. van der Weg, B. Meier, R. Borovicka, J. Beglinger, C. Vallet, C. Maerten, P. Rüegg, C. Dorta, G. info:eu-repo/semantics/article article 2016-09-15 Clinical cancer research, vol. 22, no. 18, pp. 4604-4611 info:eu-repo/semantics/altIdentifier/pissn/1078-0432 urn:issn:1078-0432 <![CDATA[A blood test for early detection of colorectal cancer is a valuable tool for testing asymptomatic individuals and reducing colorectal cancer-related mortality. The objective of this study was to develop and validate a novel blood test able to differentiate patients with colorectal cancer and adenomatous polyps (AP) from individuals with a negative colonoscopy. A case-control, multicenter clinical study was designed to collect blood samples from patients referred for colonoscopy or surgery. Predictive algorithms were developed on 75 controls, 61 large AP (LAP) ≥1 cm, and 45 colorectal cancer cases and independently validated on 74 controls, 42 LAP, and 52 colorectal cancer cases (23 stages I-II) as well as on 245 cases including other colorectal findings and diseases other than colorectal cancer. The test is based on a 29-gene panel expressed in peripheral blood mononuclear cells alone or in combination with established plasma tumor markers. The 29-gene algorithm detected colorectal cancer and LAP with a sensitivity of 79.5% and 55.4%, respectively, with 90.0% specificity. Combination with the protein tumor markers carcinoembryonic antigen (CEA) and CYFRA21-2 resulted in a specificity increase (92.2%) with a sensitivity for colorectal cancer and LAP detection of 78.1% and 52.3%, respectively. We report the validation of a novel blood test, Colox®, for the detection of colorectal cancer and LAP based on a 29-gene panel and the CEA and CYFRA21-1 plasma biomarkers. The performance and convenience of this routine blood test provide physicians a useful tool to test average-risk individuals unwilling to undergo upfront colonoscopy. Clin Cancer Res; 22(18); 4604-11. ©2016 AACR

Quelles prestations du pharmacien d'officine peuvent améliorer l'efficience des traitements médicamenteux? : le pharmacien d'officine et l'efficience des traitements médicamenteux : prestations actuelles et futures et conditions pour leur mise en oeuvre

[Table des matières] 1. Introduction. 2. But de l'étude et méthodes de travail. 3. Les médicaments. 3.1. Le marché des médicaments en Suisse. 3.2. Les caractéristiques des médicaments. 3.3. Les problèmes liés aux médicaments. 3.4. Morbidité et mortalité liées aux médicaments. 4. Rôle du pharmacien. 4.1. Evolution du rôle du pharmacien d'officine. 4.2. Situation actuelle en Suisse. 4.3. Fédération internationale pharmaceutique. 4.3.1. Philosophie de base adoptée par la FIP. 5. Nouvelles prestations du pharmacien. 5.1. Assistance pharmaceutique des homes. 5.1.2. Résultats d'une expérience fribourgeoise. 5.2. Les cercles de qualité. 5.3. Self-care. 5.4. Les soins pharmaceutiques, la gestion par pathologie. 6. Changement de pratique en Suisse

Determinants of generic drug substitution in Switzerland.

Background: Since generic drugs have the same therapeutic effect as the original formulation but at generally lower costs, their use should be more heavily promoted. However, a considerable number of barriers to their wider use have been observed in many countries. The present study examines the influence of patients, physicians and certain characteristics of the generics' market on generic substitution in Switzerland.Methods: We used reimbursement claims' data submitted to a large health insurer by insured individuals living in one of Switzerland's three linguistic regions during 2003. All dispensed drugs studied here were substitutable. The outcome (use of a generic or not) was modelled by logistic regression, adjusted for patients' characteristics (gender, age, treatment complexity, substitution groups) and with several variables describing reimbursement incentives (deductible, co-payments) and the generics' market (prices, packaging, co-branded original, number of available generics, etc.).Results: The overall generics' substitution rate for 173,212 dispensed prescriptions was 31%, though this varied considerably across cantons. Poor health status (older patients, complex treatments) was associated with lower generic use. Higher rates were associated with higher out-of-pocket costs, greater price differences between the original and the generic, and with the number of generics on the market, while reformulation and repackaging were associated with lower rates. The substitution rate was 13% lower among hospital physicians. The adoption of the prescribing practices of the canton with the highest substitution rate would increase substitution in other cantons to as much as 26%.Conclusions: Patient health status explained a part of the reluctance to substitute an original formulation by a generic. Economic incentives were efficient, but with a moderate global effect. The huge interregional differences indicated that prescribing behaviours and beliefs are probably the main determinant of generic substitution