Functional heterogeneity of CD4+ T cells in liver inflammation

Frugal dentistry is derived from the term 'frugal' (meaning simple, economical, usable, suitable). It focuses on dental interventions, which on one hand leads to a cost reduction compared to treatment alternatives and on the other hand focuses on dental core functionalities taking into account the patient's needs. In 2020, the World Health Organization (WHO) highlighted the urgency to prioritize cost-effective and affordable interventions.Against this background, a classification and review of frugal dentistry is carried out in this article. To what extent its objectives can be substantiated is investigated. Based on literature sources and an exemplary clinical presentation, options for frugal dentistry are shown. In addition, examples of potential frugal interventions and innovations are named and explained for a number of subject fields in dentistry. There are serious deficits in the systematic development and implementation of frugal dentistry. Numerous efforts in research, teaching, and patient care are therefore still required

Anti-inflammatory microenvironment of esophageal adenocarcinomas negatively impacts survival

Objective!#!Reflux promotes esophageal adenocarcinomas (EACs) creating a chronic inflammatory environment. Survival rates are low due to early local recurrences and distant metastasis. Hence, there is a need for new potential treatment options like immunotherapies. However, the inflammatory microenvironment in EACs and its impact on patient outcome remain to be fully understood.!##!Methods!#!mRNA expression levels of pro- and anti-inflammatory markers in 39 EAC patients without neoadjuvant radio-chemotherapy were measured. Data were confirmed using flow cytometric analysis of freshly resected surgical specimens. Inflammatory alterations in premalignant lesions of Barrett's esophagus were analyzed by immunohistochemistry.!##!Results!#!Expression levels of IL22 were reduced in EAC, while expression levels of FOXP3, IL10 and CTLA4 were increased. Flow cytometry demonstrated a strong infiltration of CD4!##!Conclusion!#!EAC shows an anti-inflammatory environment, which strongly affects patient survival. The microscopically unaltered peritumoral tissue shows a similar anti-inflammatory pattern indicating an immunological field effect, which might contribute to early local recurrences despite radical resection. These data suggest that using checkpoint inhibitors targeting anti-inflammatory T cells would be a promising therapeutic strategy in EAC