5 research outputs found
Myelodysplastic syndrome and secondary acute leukemia after treatment of essential thrombocythemia with hydroxyurea
Somatostatin receptor scintigraphy in cutaneous malignant lymphomas
Background: Lymphoid cells may express somatostatin receptors (SS-Rs) on their cell surface.
Therefore radiolabeled somatostalin analogues may be used to visualize SS-R-positive
lymphoid neoplasms in vivo. Exact staging is the basis for treatment decisions in cutaneous
malignant lymphoma. We considered the possibility that SS-R scintigraphy might offer a
clinically useful method of diagnostic imaging in patients with cutaneous malignant
lymphoma.
Objective: We evaluated SS-R scintigraphy in comparison with conventional staging methods
in the staging of cutaneous malignant lymphoma.
Methods: We conducted a prospective study in 14 consecutive patients with histologically
proven cutaneous malignant lymphoma. SS-R scintigraphy was compared with physical, radiologic,
and bone marrow examinations. Lymph node excisions were performed in patients
with palpable lymph nodes.
Results: SS-R scintigraphy was positive in the lymph nodes in all four patients with malignant
lymph node infiltration and negative in the three patients with dermatopathic lymphadenopathy.
In two patients, previously unsuspected lymphoma localizations were visualized by
SS-R scintigraphy. In only three patients all skin lesions were visualized by SS-R scintigraphy;
these three patients had not been treated with topical corticosteroids. SS-R scintigraphy
failed to detect an adrenal mass in one patient and bone marrow infiltration in two patients.
Conclusion: SS-R scintigraphy may help distinguish dermatopathic lymphadenopathy from
malignant lymph node infiltration in patients with cutaneous malignant lymphoma