Temporal profile curves for calcium transients during single twitch activation (A) and tetanic stimulation (B).

<p>Each line corresponds to the average of all single fiber measurements that have been included in the statistical analysis. For improving the visibility of group differences, the time interval was adjusted accordingly. The red and black dashed lines indicate the drift of the baseline calcium during the tetanic stimulation. Treatment of fibers with 25 μM FK506 (red line) leads to an elevated inter-peak-baseline level compared to untreated control fibers (black line). </p

Energy utilization in FDB fibers.

<p>The graph shows the estimates for the relative baseline change ± SEM after different treatment conditions (pretreatment/injection). Changes, displayed in %, are statistically valuated by the corresponding p-value. The increased SERCA activity observed after FK506 injection can be incompletely normalized by pretreatment with JTV-519.</p

The graph shows the estimates for the AUC (mean±SEM) for the four groups.

<p>Changes, displayed in %, are statistically valuated by the corresponding p-value. n: number of fibers measured per group. Control (n=42), FK506 (n=42), JTV-519 (n=53) and JTV-519 + FK506 (n= 44).</p