Фторидная технология получения титановых порошков

Обоснована необходимость разработки новой технологии переработки титансодержащих концентратов. Выполнено исследование процесса фторирования рутилового концентрата элементным фтором. Описаны процессы, протекающие при электролитическом получении титановых порошков во фторидных расплавах TiF4. Для отмывки от примесей катодного осадка предложено две технологии – в смеси неорганических кислот и безводным HF; показаны преимущества отмывки HF; содержание примесей в порошке титана, полученном отмывкой в безводном HF несколько ниже, чем при "кислотной" отмывке. При промышленном осуществлении процесса HF рециркулирует в схеме, обеспечивая экологическую безопасность и низкую себестоимость Ti.The brief review of industrial technologies of processing the titanium containing concentrates has been carried out. The research of the fluorination process of rutile concentrates with element fluorine was carried out. The processes occurring during the electrolysis of titanic powders from fluoride fusions, from TiF4, are described. In order to wash off impurities of cathode deposit, two techniques were proposed - in a mixture of inorganic acids and anhydrous HF; advantages of washing off with HF are shown; the impurity content in the titanium powder obtained by washing off in anhydrous HF is slightly lower than at "acid" washing off. In the industrial process implementation HF recycles tin a circuit that ensures environmental safety of production and low production cost of obtained Ti

Внедрение организационных инноваций в обустройстве инфраструктуры нефтегазовой отрасли

Инфраструктура занимает одну из важнейших должностей в организации, при грамотной инфраструктуре: организация несёт значительно меньше производственных потерь. Мы рассмотрим возможность внедрения инноваций в организационную деятельность в обустройстве инфраструктуры нефтегазовой отрасли.Infrastructure occupies one of the most important positions in the organization, with a competent infrastructure: the organization suffers significantly less production losses. We will consider the possibility of introducing innovations in organizational activities in arranging the infrastructure of the oil and gas industry

Jejunalsonden bei Kindern und Jugendlichen

<jats:title>Zusammenfassung</jats:title><jats:p>Die Ernährung über eine jejunale Sonde wird immer häufiger bei jenen Kindern notwendig, deren kalorischer Bedarf durch gastrale Ernährung nicht ausreichend gedeckt werden kann. Ursächlich hierfür können die Intoleranz gastral zugeführter Nahrung oder eine ausgeprägte gastroösophageale Refluxkrankheit (GÖRK) sein. Da nach Anlage der Jejunalsonde häufig regelmäßige Sondenwechsel notwendig werden, ist eine jejunale Sonde oft nur eine vorübergehende Lösung bis zur perkutanen Anlage eines Jejunostomas (mit oder ohne Antirefluxoperation) oder als Alternative vor einer etwaigen Antirefluxoperation.</jats:p><jats:p>Bevor eine jejunale Sonde gelegt wird, sollte eine Nahrungsintoleranz aufgrund anatomischer oder nicht gastrointestinal bedingter Probleme ausgeschlossen werden.</jats:p><jats:p>Die Versorgung eines Kindes, bei dem die Anlage einer jejunalen Sonde geplant ist, sollte durch ein multidisziplinäres Team, bestehend aus u. a. einem Kindergastroenterologen/einer Kindergastroenterologin, einer Ernährungsfachkraft, einem Psychologen/einer Psychologin und einem Logopäden/einer Logopädin, erfolgen. Das multidisziplinäre Team sollte bereits vor Indikationsstellung die Nahrung anpassen, das Kind logopädisch evaluiert haben und die Familie psychologisch und medizinisch mitbetreuen.</jats:p><jats:p>Eine adäquate Planung, welche auch ethische Aspekte beinhaltet, garantiert, dass sowohl der Patient/die Patientin, die Eltern und Betreuungspersonen wie auch das behandelnde Team ein klares Verständnis der Indikation und Gründe für die Anlage einer jejunalen Sonde haben. Dabei sollten auch die Fortsetzung einer möglichen oralen Ernährung und eine Sondenentwöhnung diskutiert werden.</jats:p><jats:p>Diese Übersicht beinhaltet Handlungsempfehlungen zur Indikationsstellung für den Einsatz jejunaler Sonden, gepaart mit praktischen Überlegungen, welche die Verwendung und die Sicherheit der jejunalen Sondenernährung im Kindes- und Jugendalter optimieren sollen.</jats:p&gt

Jejunal tube feeding in children and adolescents

Jejunal tube feeding is increasingly becoming the standard of care for children in whom gastric tube feeding is insufficient to fulfil caloric needs. Jejunal tube feeding is defined as postpyloric feeding through a feeding tube with its tip placed distally to the Treitz ligament. The jejunal tube bypasses the stomach when gastric feeding is not tolerated or is associated with unacceptable complications including significant gastroesophageal reflux disease. There is growing evidence suggesting that feeding by jejunal tube is a safe and effective means of enteral feeding in children and adolescents; however, because of the frequent need for tube maintenance and replacement leading to increased morbidity, gastrojejunal tube feeding is more a temporary alternative to, for example, cutaneous jejunostomy and antireflux surgery. A number of factors should be considered before placement of a jejunal or a gastrojejunal tube. The symptoms of feeding failure, such as nausea, vomiting, gagging, retching and volume intolerance may be caused by anatomical or nongastrointestinal problems, which will need to be dealt with before considering placement of a jejunal tube. The decision to place a jejunal tube has to be made by a multidisciplinary team, working in close cooperation and providing active follow-up and care. The management of a child awaiting a jejunal feeding tube should begin well before its insertion. The multidisciplinary team should be familiar with and have access to a range of alternative strategies to the insertion of a jejunal feeding tube. These may include food or regimen changes, specific feeding therapy, speech and swallowing assessments and access to psychological support. The team should include a pediatric gastroenterologist, a dietitian, a psychologist, and a speech and language therapist. Adequate planning, including discussion of ethical issues, guarantees that all parties have a clear understanding of the indications and rationale for placement of a jejunal tube. In addition, ongoing and future strategies to increase possible oral feeding and enable weaning off the jejunal tube should be discussed. The aim of this article is to provide a comprehensive guide for healthcare professionals on the safe, effective, and appropriate use of jejunal feeding tubes in children and adolescents

Crohn' s Disease Exclusion Diet - an alternative to exlusive enteral nutritional therapy in children and adolescentswith Crohn 's disease? Statement of the GPGE working groups CEDATA and Nutrition/Nutrition Medicine

Epidemiological an clinical observations as well as results from animal studies indicate that nutrition can play a role in the development of inflammatory bowel disease (IBD). Exclusive enteral nutrition therapy represents an example for modulating inflammatory responses solely through diet modification. Therefore, caretakers, patients, families, doctors and nutritionists seek for more dietary options to control IBD. These options include partial enteral nutrition therapy as for example the socalled Crohn's disease exclusion diet. The following statement summarizes existing data and provides recommendations for the current management of enteral nutrition therapy in pediatric Crohn's disease

[Fecal Microbiota Transfer (FMT) in Children and Adolescents - Review and statement by the GPGE microbiome working group].

The human microbiome and especially the gastrointestinal microbiota are associated with health and disease. Disturbance in the composition or function of fecal microbiota (dysbiosis) plays a role in the development of pediatric gastrointestinal diseases. Fecal microbiota transfer (FMT) is a special intervention, where microbiota are transferred from a healthy donor.In this review we describe the current state of knowledge for FMT in pediatric patients. There is satisfactory evidence concerning FMT in patients with recurrent C. difficile infection. For inflammatory bowel disease, few studies show a potential benefit.Adverse events occurred frequently in clinical studies, but were mostly mild and transient. There are hardly any data on long-term side effects of FMT, which are particularly significant for pediatrics. In practice, there is uncertainty as to which application route, dosage or frequency should be used. Legally, donor stool is considered a drug in German-speaking countries, for which no marketing authorization exists.In conclusion, knowledge about physiology, efficacy and side effects of FMT is insufficient and legal concerns complicate its implementation. More studies on this topic are needed urgently

Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results

Cystic fibrosis (CF; OMIM 219700) is a rare genetic disorder caused by a chloride channel defect, resulting in lung disease, pancreas insufficiency and liver impairment. Altered L-arginine (Arg)/nitric oxide (NO) metabolism has been observed in CF patients’ lungs and in connection with malnutrition. The aim of the present study was to investigate markers of the Arg/NO pathway in the plasma and urine of CF patients and to identify possible risk factors, especially associated with malnutrition. We measured the major NO metabolites nitrite and nitrate, Arg, a semi-essential amino acid and NO precursor, the NO synthesis inhibitor asymmetric dimethylarginine (ADMA) and its major urinary metabolite dimethylamine (DMA) in plasma and urine samples of 70 pediatric CF patients and 78 age-matched healthy controls. Biomarkers were determined by gas chromatography–mass spectrometry and high-performance liquid chromatography. We observed higher plasma Arg (90.3 vs. 75.6 µM, p < 0.0001), ADMA (0.62 vs. 0.57 µM, p = 0.03), Arg/ADMA ratio (148 vs. 135, p = 0.01), nitrite (2.07 vs. 1.95 µM, p = 0.03) and nitrate (43.3 vs. 33.1 µM, p < 0.001) concentrations, as well as higher urinary DMA (57.9 vs. 40.7 µM/mM creatinine, p < 0.001) and nitrate (159 vs. 115 µM/mM creatinine, p = 0.001) excretion rates in the CF patients compared to healthy controls. CF patients with pancreatic sufficiency showed plasma concentrations of the biomarkers comparable to those of healthy controls. Malnourished CF patients had lower Arg/ADMA ratios (p = 0.02), indicating a higher NO synthesis capacity in sufficiently nourished CF patients. We conclude that NO production, protein-arginine dimethylation, and ADMA metabolism is increased in pediatric CF patients. Pancreas and liver function influence Arg/NO metabolism. Good nutritional status is associated with higher NO synthesis capacity and lower protein-arginine dimethylation