Hemmung der osteoklastären Funktion durch neue Src-Kinaseinhibitoren vom Pyrazolo[3,4-d]pyrimidin-typ

Im Rahmen dieser Diplomarbeit wurden Substanzen vom Pyrazolo[3,4 d]pyrimidin-typ mit den Kurzbezeichnungen SI83, S7, SI20, S13 und S31 auf ihre Eigenschaft hin untersucht, osteoklastäre Prozesse und Funktionen sowie die Genese von Osteoklasten zu hemmen

Математическое моделирование процесса сушки древесного биотоплива

Объектом исследования является древесина хвойных (кедр, сосна, лиственница, пихта) и лиственных (береза, осина, клен, тополь) пород. Предмет исследования – математическое моделирование процесса сушки древесной биомассы. Цель работы - теоретическое исследование влияния теплофизических свойств материалов растительного происхождения на процесс сушки и анализ процесса тепломассопереноса при сушке влажной древесины различного типа.The object of the study is coniferous wood (cedar, pine, larch, fir) and deciduous (birch, aspen, maple, poplar) rocks. The subject of the study is mathematical modeling of the drying process of wood biomass. The aim of the work is a theoretical study of the effect of thermal properties of materials of plant origin on the drying process and an analysis of the process of heat and mass transfer when drying moist wood of various types

Implementation of REACH in the New Member States. Part one: Overview of the Chemical and Speciality Chemical Sector in the New Member States

This report informs about potential impacts of the European regulation concerning the registration, evaluation, authorisation and restriction of chemicals REACH (Regulation (EC) No 1907/2006) in the New Member States. It consists of two parts: 1) "Implementation of REACH in the New Member States – Part one: overview of the chemical and specialty chemical sector in the New Member States", and 2) "Implementation of REACH in the New Member States – Part two: Business case studies in selected New Member States". The first report gives a general overview of the chemical sector in all New Member States and provides key macroeconomic data for the description of the chemical sector as a whole in each of the countries. This includes the sectors development, major developments including trade with EU-15 and non-EU countries, and a description of sub-sectors according to NACE categories. Furthermore, the first report describes the impact on the chemical industry through the implementation of the Chemicals Acquis and the Accession to the EU, and derives the implications for the adoption of REACH in the New Member States. Finally, the report outlines REACH Impact studies which are available in the New Member States. The second report analyses the ability of specialty chemicals companies in selected countries to implement REACH. This ability is examined on the basis of techno-economic case studies. From the economic aspect, the impact on costs and prices is analysed, substance withdrawal, administrative impact, capacity needs and the competitiveness on European and international markets. From the technological point of view the impact of REACH on innovation, replacement of substances and process adaptation is looked at. The strategic analysis looked at alternatives to cope with REACH (such as the import of components, relocation to non-EU countries etc.), the potential of companies to adapt to the changing legal framework (including the implementation of the environmental acquis) and the relative importance of REACH as one amongst different drivers for change.JRC.J.2-Competitiveness and Sustainabilit

Исследование влияния природы растворителя, используемого при получении электродной мембраны, на работу Ni-селективного электрода при определении ионов никеля (LL) в водных средах

Исследовано влияние природы растворителей (бензиловый спирт и хлорфенол), используемых для изготовления полимерной электродной мембраны твердофазного никельселективного электрода на основе никельгексационоферратов ({Ni2[Fe(CN)6]}), иммобилизованных в полиэтилентерефталатную (ПЭТФ) матрицу для определения ионов никеля в водных средах. Установлено, что мембраны, полученные на основе бензилового спирта имеют более высокие электродные показатели по сходимости и воспроизводимости потенциалов, стабильности работы, низком дрейфе и времени отклика электрода по сравнению с мембранами на основе хлорфенола и могут быть рекомендованы к использованию в никель селективных электродах.The influence of the nature of the solvents (benzyl alcohol and chlorophenol) used to fabricate a polymer electrode membrane of a solid-phase nickel selective electrode based on nickelhexacetanoferrates ({Ni2 [Fe (CN) 6]}) immobilized in a polyethylene terephthalate (PET) matrix for the determination of nickel ions in aqueous media . It has been established that membranes obtained on the basis of benzyl alcohol have higher electrode indices for the convergence and reproducibility of potentials, stability of operation, low drift and electrode response time compared to chlorophenol-based membranes, and can be recommended for use in nickel selective electrodes

Implementation of REACH in the New Member States - Part two: Business Case Studies in Selected New Member States

This report informs about potential impacts of the European regulation concerning the registration, evaluation, authorisation and restriction of chemicals REACH (Regulation (EC) No 1907/2006) in the New Member States . It consists of two parts: 1) "Implementation of REACH in the New Member States – Part one: overview of the chemical and specialty chemical sector in the New Member States", and 2) "Implementation of REACH in the New Member States – Part two: Business case studies in selected New Member States". The first report gives a general overview of the chemical sector in all New Member States and provides key macroeconomic data for the description of the chemical sector as a whole in each of the countries. This includes the sectors development, major developments including trade with EU-15 and non-EU countries, and a description of sub-sectors according to NACE categories. Furthermore, the first report describes the impact on the chemical industry through the implementation of the Chemicals Acquis and the Accession to the EU, and derives the implications for the adoption of REACH in the New Member States. Finally, the report outlines REACH Impact studies which are available in the New Member States . The second report analyses the ability of specialty chemicals companies in selected countries to implement REACH . This ability is examined on the basis of techno-economic case studies. From the economic aspect, the impact on costs and prices is analysed, substance withdrawal, administrative impact, capacity needs and the competitiveness on European and international markets. From the technological point of view the impact of REACH on innovation, replacement of substances and process adaptation is looked at. The strategic analysis looked at alternatives to cope with REACH (such as the import of components, relocation to non-EU countries etc.), the potential of companies to adapt to the changing legal framework (including the implementation of the environmental acquis) and the relative importance of REACH as one amongst different drivers for change.JRC.J.2-Competitiveness and Sustainabilit

Renewable Energy in the Context of Sustainable Development

Historically, economic development has been strongly correlated with increasing energy use and growth of greenhouse gas (GHG) emissions. Renewable energy (RE) can help decouple that correlation, contributing to sustainable development (SD). In addition, RE offers the opportunity to improve access to modern energy services for the poorest members of society, which is crucial for the achievement of any single of the eight Millennium Development Goals. Theoretical concepts of SD can provide useful frameworks to assess the interactions between SD and RE. SD addresses concerns about relationships between human society and nature. Traditionally, SD has been framed in the three-pillar model—Economy, Ecology, and Society—allowing a schematic categorization of development goals, with the three pillars being interdependent and mutually reinforcing. Within another conceptual framework, SD can be oriented along a continuum between the two paradigms of weak sustainability and strong sustainability. The two paradigms differ in assumptions about the substitutability of natural and human-made capital. RE can contribute to the development goals of the three-pillar model and can be assessed in terms of both weak and strong SD, since RE utilization is defined as sustaining natural capital as long as its resource use does not reduce the potential for future harvest. The relationship between RE and SD can be viewed as a hierarchy of goals and constraints that involve both global and regional or local considerations. Though the exact contribution of RE to SD has to be evaluated in a country specifi c context, RE offers the opportunity to contribute to a number of important SD goals: (1) social and economic development; (2) energy access; (3) energy security; (4) climate change mitigation and the reduction of environmental and health impacts. The mitigation of dangerous anthropogenic climate change is seen as one strong driving force behind the increased use of RE worldwide. The chapter provides an overview of the scientific literature on the relationship between these four SD goals and RE and, at times, fossil and nuclear energy technologies. The assessments are based on different methodological tools, including bottom-up indicators derived from attributional lifecycle assessments (LCA) or energy statistics, dynamic integrated modelling approaches, and qualitative analyses. Countries at different levels of development have different incentives and socioeconomic SD goals to advance RE. The creation of employment opportunities and actively promoting structural change in the economy are seen, especially in industrialized countries, as goals that support the promotion of RE. However, the associated costs are a major factor determining the desirability of RE to meet increasing energy demand and concerns have been voiced that increased energy prices might endanger industrializing countries’ development prospects; this underlines the need for a concomitant discussion about the details of an international burden-sharing regime. Still, decentralized grids based on RE have expanded and already improved energy access in developing countries. Under favorable conditions, cost savings in comparison to non-RE use exist, in particular in remote areas and in poor rural areas lacking centralized energy access. In addition, non-electrical RE technologies offer opportunities for modernization of energy services, for example, using solar energy for water heating and crop drying, biofuels for transportation, biogas and modern biomass for heating, cooling, cooking and lighting, and wind for water pumping. RE deployment can contribute to energy security by diversifying energy sources and diminishing dependence on a limited number of suppliers, therefore reducing the economy’s vulnerability to price volatility. Many developing countries specifically link energy access and security issues to include stability and reliability of local supply in their definition of energy security. Supporting the SD goal to mitigate environmental impacts from energy systems, RE technologies can provide important benefits compared to fossil fuels, in particular regarding GHG emissions. Maximizing these benefits often depends on the specific technology, management, and site characteristics associated with each RE project, especially with respect to land use change (LUC) impacts. Lifecycle assessments for electricity generation indicate that GHG emissions from RE technologies are, in general, considerably lower than those associated with fossil fuel options, and in a range of conditions, less than fossil fuels employing carbon capture and storage (CCS). The maximum estimate for concentrating solar power (CSP), geothermal, hydropower, ocean and wind energy is less than or equal to 100 g CO2eq/kWh, and median values for all RE range from 4 to 46 g CO2eq/kWh. The GHG balances of bioenergy production, however, have considerable uncertainties, mostly related to land management and LUC. Excluding LUC, most bioenergy systems reduce GHG emissions compared to fossil-fueled systems and can lead to avoided GHG emissions from residues and wastes in landfill disposals and co-products; the combination of bioenergy with CCS may provide for further reductions. For transport fuels, some first-generation biofuels result in relatively modest GHG mitigation potential, while most next-generation biofuels could provide greater climate benefits. To optimize benefits from bioenergy production, it is critical to reduce uncertainties and to consider ways to mitigate the risk of bioenergy-induced LUC. RE technologies can also offer benefits with respect to air pollution and health. Non-combustion-based RE power generation technologies have the potential to significantly reduce local and regional air pollution and lower associated health impacts compared to fossil-based power generation. Impacts on water and biodiversity, however, depend on local conditions. In areas where water scarcity is already a concern, non-thermal RE technologies or thermal RE technologies using dry cooling can provide energy services without additional stress on water resources. Conventional water-cooled thermal power plants may be especially vulnerable to conditions of water scarcity and climate change. Hydropower and some bioenergy systems are dependent on water availability, and can either increase competition or mitigate water scarcity. RE specific impacts on biodiversity may be positive or negative; the degree of these impacts will be determined by site-specific conditions. Accident risks of RE technologies are not negligible, but the technologies’ often decentralized structure strongly limits the potential for disastrous consequences in terms of fatalities. However, dams associated with some hydropower projects may create a specific risk depending on site-specific factors. The scenario literature that describes global mitigation pathways for RE deployment can provide some insights into associated SD implications. Putting an upper limit on future GHG emissions results in welfare losses (usually measured as gross domestic product or consumption foregone), disregarding the costs of climate change impacts. These welfare losses are based on assumptions about the availability and costs of mitigation technologies and increase when the availability of technological alternatives for constraining GHGs, for example, RE technologies, is limited. Scenario analyses show that developing countries are likely to see most of the expansion of RE production. Increasing energy access is not necessarily beneficial for all aspects of SD, as a shift to modern energy away from, for example, traditional biomass could simply be a shift to fossil fuels. In general, available scenario analyses highlight the role of policies and finance for increased energy access, even though forced shifts to RE that would provide access to modern energy services could negatively affect household budgets. To the extent that RE deployment in mitigation scenarios contributes to diversifying the energy portfolio, it has the potential to enhance energy security by making the energy system less susceptible to (sudden) energy supply disruption. In scenarios, this role of RE will vary with the energy form. With appropriate carbon mitigation policies in place, electricity generation can be relatively easily decarbonized through RE sources that have the potential to replace concentrated and increasingly scarce fossil fuels in the building and industry sectors. By contrast, the demand for liquid fuels in the transport sector remains inelastic if no technological breakthrough can be achieved. Therefore oil and related energy security concerns are likely to continue to play a role in the future global energy system; as compared to today these will be seen more prominently in developing countries. In order to take account of environmental and health impacts from energy systems, several models have included explicit representation of these, such as sulphate pollution. Some scenario results show that climate policy can help drive improvements in local air pollution (i.e., particulate matter), but air pollution reduction policies alone do not necessarily drive reductions in GHG emissions. Another implication of some potential energy trajectories is the possible diversion of land to support biofuel production. Scenario results have pointed at the possibility that climate policy could drive widespread deforestation if not accompanied by other policy measures, with land use being shifted to bioenergy crops with possibly adverse SD implications, including GHG emissions. 712 Renewable Energy in the Context of Sustainable Development Chapter 9 The integration of RE policies and measures in SD strategies at various levels can help overcome existing barriers and create opportunities for RE deployment in line with meeting SD goals. In the context of SD, barriers continue to impede RE deployment. Besides market-related and economic barriers, those barriers intrinsically linked to societal and personal values and norms will fundamentally affect the perception and acceptance of RE technologies and related deployment impacts by individuals, groups and societies. Dedicated communication efforts are therefore a crucial component of any transformation strategy and local SD initiatives can play an important role in this context. At international and national levels, strategies should include: the removal of mechanisms that are perceived to work against SD; mechanisms for SD that internalize environmental and social externalities; and RE strategies that support low-carbon, green and sustainable development including leapfrogging. The assessment has shown that RE can contribute to SD to varying degrees; more interdisciplinary research is needed to close existing knowledge gaps. While benefi ts with respect to reduced environmental and health impacts may appear more clear-cut, the exact contribution to, for example, social and economic development is more ambiguous. In order to improve the knowledge regarding the interrelations between SD and RE and to fi nd answers to the question of an effective, economically effi cient and socially acceptable transformation of the energy system, a much closer integration of insights from social, natural and economic sciences (e.g., through risk analysis approaches), refl ecting the different (especially intertemporal, spatial and intra-generational) dimensions of sustainability, is required. So far, the knowledge base is often limited to very narrow views from specifi c branches of research, which do not fully account for the complexity of the issue

Exposure assessment of process-related contaminants in food by biomarker monitoring

Exposure assessment is a fundamental part of the risk assessment paradigm, but can often present a number of challenges and uncertainties. This is especially the case for process contaminants formed during the processing, e.g. heating of food, since they are in part highly reactive and/or volatile, thus making exposure assessment by analysing contents in food unreliable. New approaches are therefore required to accurately assess consumer exposure and thus better inform the risk assessment. Such novel approaches may include the use of biomarkers, physiologically based kinetic (PBK) modelling-facilitated reverse dosimetry, and/or duplicate diet studies. This review focuses on the state of the art with respect to the use of biomarkers of exposure for the process contaminants acrylamide, 3-MCPD esters, glycidyl esters, furan and acrolein. From the overview presented, it becomes clear that the field of assessing human exposure to process-related contaminants in food by biomarker monitoring is promising and strongly developing. The current state of the art as well as the existing data gaps and challenges for the future were defined. They include (1) using PBK modelling and duplicate diet studies to establish, preferably in humans, correlations between external exposure and biomarkers; (2) elucidation of the possible endogenous formation of the process-related contaminants and the resulting biomarker levels; (3) the influence of inter-individual variations and how to include that in the biomarker-based exposure predictions; (4) the correction for confounding factors; (5) the value of the different biomarkers in relation to exposure scenario’s and risk assessment, and (6) the possibilities of novel methodologies. In spite of these challenges it can be concluded that biomarker-based exposure assessment provides a unique opportunity to more accurately assess consumer exposure to process-related contaminants in food and thus to better inform risk assessment

Determination of nutrient salts by automatic methods both in seawater and brackish water: the phosphate blank

9 páginas, 2 tablas, 2 figurasThe main inconvenience in determining nutrients in seawater by automatic methods is simply solved: the preparation of a suitable blank which corrects the effect of the refractive index change on the recorded signal. Two procedures are proposed, one physical (a simple equation to estimate the effect) and the other chemical (removal of the dissolved phosphorus with ferric hydroxide).Support for this work came from CICYT (MAR88-0245 project) and Conselleria de Pesca de la Xunta de GaliciaPeer reviewe