Electrodeposition of conducting polymer fibers

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.Includes bibliographical references (leaf 35).Conducting polymers are materials that possess the electrical conductivity of metals while still retaining the mechanical properties such as flexibility of traditional polymers. Polypyrrole (PPy) is one of the more commonly studied electrically conducting polymers due to its high conductivity and stability in ambient conditions. A one step electrochemical process for growing macroscopic conducting polymer fibers previously described in Li et al's article (Science, 1993) was used to grow PPy fibers. Based on a schematic of the electrochemical flow cell used in the electrodeposition process, a physical electrochemical flow cell was constructed. Several trials were carried out in an attempt to repeatedly grow polymer fibers. The fibers grown from successful trials were analyzed and characterized by qualities such as length, diameter, surface texture, conductivity, and elasticity. There is room for further study involving optimization of parameters such as temperature, monomer concentration, and flow velocity of the monomer solution.by Angela Y. Chen.S.B

Large displacement fast conducting polymer actuators

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.Includes bibliographical references (leaves 93-96).Conducting polymers are a promising class of electroactive materials that undergo volumetric changes under applied potentials, which make them particularly useful for many actuation applications. Polypyrrole , is one of the most common conducting polymers of choice for the development of actuator technologies and has been well characterized in its mechanical, electrical, and electrochemical response. Although capable of producing almost 10 times more active stress for a given cross-sectional area than skeletal muscle, strains are relatively low on the order of 1 to 2 %, as are strain rates, which are on the order of a couple percent per second. Small strains can be amplified to produce large bending displacements by configuring the conducting polymer film in a trilayer configuration with two conducting polymer films sandwiching an electrolyte gel layer. This thesis focuses on the development of conducting polymer bending actuators in air. There is a strong correlation found between applied voltage, temperature, and the speed of actuation. Several experiments were carried out to determine the effect of temperature on the mechanical, electrical, and electrochemical properties of the components of the trilayer.(cont.) This data coupled with thermal profiles of trilayers during actuation, electrochemical profiles, and force generation plots of the trilayers shed light on how these bending actuators can be optimized and integrated into different applications such as propulsion mechanisms for autonomous underwater vehicles.by Angela Ying Ju Chen.S.M

EUSO-SPB2 sensitivity to macroscopic dark matter

Macroscopic dark matter (or macro) provides a broad class of alternative candidates to particle dark matter. These candidates would transfer energy primarily through elastic scattering, and this linear energy deposition would produce observable signals if a macro were to traverse the atmosphere. We study the fluorescence emission produced by a macro passing through the atmosphere. We estimate the sensitivity of EUSO-SPB2 to constrain the two-dimensional parameter space ($\sigma$ vs. $M$), where $M$ is the macro mass and $\sigma$ its cross sectional area.Comment: To be published in the Proceedings of the 37th International Cosmic Ray Conference (ICRC 2012), Berlin, 12 -23 July 202

Objective response to immune checkpoint inhibitor therapy in NRAS-mutant melanoma: A systematic review and meta-analysis

INTRODUCTION: METHODS: We performed a comprehensive literature search across several large databases. Inclusion criteria were trials, cohorts, and large case series that analyzed the primary outcome of objective response rate by RESULTS: Data on 1770 patients from ten articles were pooled for meta-analysis, and the objective response rate to ICIs was calculated to compare DISCUSSION: In this meta-analysis evaluating the impact o

Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells

Mutations in the gene encoding DNA methyltransferase 3A

Modular Superconducting Qubit Architecture with a Multi-chip Tunable Coupler

We use a floating tunable coupler to mediate interactions between qubits on separate chips to build a modular architecture. We demonstrate three different designs of multi-chip tunable couplers using vacuum gap capacitors or superconducting indium bump bonds to connect the coupler to a microwave line on a common substrate and then connect to the qubit on the next chip. We show that the zero-coupling condition between qubits on separate chips can be achieved in each design and that the relaxation rates for the coupler and qubits are not noticeably affected by the extra circuit elements. Finally, we demonstrate two-qubit gate operations with fidelity at the same level as qubits with a tunable coupler on a single chip. Using one or more indium bonds does not degrade qubit coherence or impact the performance of two-qubit gates.Comment: 9 pages, 6 figure

MTORC1 signaling and regulation of pancreatic β-cell mass

The capacity of β cells to expand in response to insulin resistance is a critical factor in the development of type 2 diabetes. Proliferation of β cells is a major component for these adaptive responses in animal models. The extracellular signals responsible for β-cell expansion include growth factors, such as insulin, and nutrients, such as glucose and amino acids. AKT activation is one of the important components linking growth signals to the regulation of β-cell expansion. Downstream of AKT, tuberous sclerosis complex 1 and 2 (TSC1/2) and mechanistic target of rapamycin complex 1 (mTORC1) signaling have emerged as prime candidates in this process, because they integrate signals from growth factors and nutrients. Recent studies demonstrate the importance of mTORC1 signaling in β cells. This review will discuss recent advances in the understanding of how this pathway regulates β-cell mass and present data on the role of TSC1 in modulation of β-cell mass. Herein, we also demonstrate that deletion of Tsc1 in pancreatic β cells results in improved glucose tolerance, hyperinsulinemia and expansion of β-cell mass that persists with aging

Cultural threats in culturally mixed encounters hamper creative performance for individuals with lower openness to experience

Ministry of Education, Singapore under its Academic Research Funding Tier

Biomarker discovery for colon cancer using a 761 gene RT-PCR assay

<p>Abstract</p> <p>Background</p> <p>Reverse transcription PCR (RT-PCR) is widely recognized to be the gold standard method for quantifying gene expression. Studies using RT-PCR technology as a discovery tool have historically been limited to relatively small gene sets compared to other gene expression platforms such as microarrays. We have recently shown that TaqMan^®RT-PCR can be scaled up to profile expression for 192 genes in fixed paraffin-embedded (FPE) clinical study tumor specimens. This technology has also been used to develop and commercialize a widely used clinical test for breast cancer prognosis and prediction, the Onco <it>type</it>DX™ assay. A similar need exists in colon cancer for a test that provides information on the likelihood of disease recurrence in colon cancer (prognosis) and the likelihood of tumor response to standard chemotherapy regimens (prediction). We have now scaled our RT-PCR assay to efficiently screen 761 biomarkers across hundreds of patient samples and applied this process to biomarker discovery in colon cancer. This screening strategy remains attractive due to the inherent advantages of maintaining platform consistency from discovery through clinical application.</p> <p>Results</p> <p>RNA was extracted from formalin fixed paraffin embedded (FPE) tissue, as old as 28 years, from 354 patients enrolled in NSABP C-01 and C-02 colon cancer studies. Multiplexed reverse transcription reactions were performed using a gene specific primer pool containing 761 unique primers. PCR was performed as independent TaqMan^®reactions for each candidate gene. Hierarchal clustering demonstrates that genes expected to co-express form obvious, distinct and in certain cases very tightly correlated clusters, validating the reliability of this technical approach to biomarker discovery.</p> <p>Conclusion</p> <p>We have developed a high throughput, quantitatively precise multi-analyte gene expression platform for biomarker discovery that approaches low density DNA arrays in numbers of genes analyzed while maintaining the high specificity, sensitivity and reproducibility that are characteristics of RT-PCR. Biomarkers discovered using this approach can be transferred to a clinical reference laboratory setting without having to re-validate the assay on a second technology platform.</p