The galaxy-halo connection of DESI luminous red galaxies with subhalo abundance matching

We use subhalo abundance and age distribution matching to create magnitude-limited mock galaxy catalogs at $z\sim0.43$, $0.52$, and $0.63$ with $z$-band and $3.4$ micron $W1$-band absolute magnitudes and ${r-z}$ and ${r-W1}$ colors. From these magnitude-limited mocks we select mock luminous red galaxy (LRG) samples according to the $(r-z)$-based (optical) and $(r-W1)$-based (infrared) selection criteria for the LRG sample of the Dark Energy Spectroscopic Instrument (DESI) Survey. Our models reproduce the number densities, luminosity functions, color distributions, and projected clustering of the DESI Legacy Surveys that are the basis for DESI LRG target selection. We predict the halo occupation statistics of both optical and IR DESI LRGs at fixed cosmology, and assess the differences between the two LRG samples. We find that IR-based SHAM modeling represents the differences between the optical and IR LRG populations better than using the $z$-band, and that age distribution matching overpredicts the clustering of LRGs, implying that galaxy color is uncorrelated with halo age in the LRG regime. Both the optical and IR DESI LRG target selections exclude some of the most luminous galaxies that would appear to be LRGs based on their position on the red sequence in optical color-magnitude space. Both selections also yield populations with a non-trivial LRG-halo connection that does not reach unity for the most massive halos. We find the IR selection achieves greater completeness ($\gtrsim 90\%$) than the optical selection across all redshift bins studied.Comment: 20 pages, 14 figures, submitted to Ap

Inorganic nanoparticles as potential regulators of immune response in dendritic cells

Aim: The spontaneous adsorption of proteins on nanoparticles (NPs) in biological media is exploited to prepare complexes of NPs and proteins from cancer cells’ lysates for application in cancer immunotherapy. Materials &amp; methods: Gold (Au) and silica NPs were synthesized, incubated with cancer cells’ lysates and characterized. Dendritic cells (DCs) were challenged with protein-coated NPs, their maturation, viability and morphology were evaluated and lymphocytes T proliferation was determined. Results: Silica and Au NPs bound different pools of biomolecules from lysates, and are therefore promising selective carriers for antigens. When incubated with immature DCs, NPs were efficiently endocytosed without cytotoxicity. Finally, protein-coated AuNPs promoted DC maturation and DC-mediated lymphocyte proliferation, at variance with lysate alone and protein-coated silica NPs, that did not promote DCs maturation. Conclusion: These results demonstrate that the spontaneous formation of protein coronas on NPs represents a possible approach to fast, easy, cost-effective DCs stimulation. </jats:p

Optical Coherence Tomography in Myocardial Infarction Management: Enhancing Precision in Percutaneous Coronary Intervention

Abstract: In acute myocardial infarction (AMI), the urgency of coronary revascularization through percutaneous coronary intervention (PCI) is paramount, offering notable advantages over pharmaco- logic treatment. However, the persistent risk of adverse events, including recurrent AMI and heart failure post-revascularization, underscores the necessity for enhanced strategies in managing coro- nary artery disease. Traditional angiography, while widely employed, presents significant limitations by providing only two-dimensional representations of complex three-dimensional vascular structures, hampering the accurate assessment of plaque characteristics and stenosis severity. Intravascular imaging, specifically optical coherence tomography (OCT), significantly addresses these limitations with superior spatial resolution compared to intravascular ultrasound (IVUS). Within the context of AMI, OCT serves dual purposes: as a diagnostic tool to accurately identify culprit lesions in ambiguous cases and as a guide for optimizing PCI procedures. Its capacity to differentiate between various mechanisms of acute coronary syndrome, such as plaque rupture and spontaneous coronary dissection, enhances its diagnostic potential. Furthermore, OCT facilitates precise lesion preparation, optimal stent sizing, and confirms stent deployment efficacy. Recent meta-analyses indicate that OCT- guided PCI markedly improves safety and efficacy in revascularization, subsequently decreasing the risks of mortality and complications. This review emphasizes the critical role of OCT in refining patient-specific therapeutic approaches, aligning with the principles of precision medicine to enhance clinical outcomes for individuals experiencing AMI

Uncertainties in limits on TeV-gravity from neutrino-induced showers

In models with TeV-scale gravity, ultrahigh energy cosmic rays can generate microscopic black holes in the collision with atmospheric and terrestrial nuclei. It has been proposed that stringent bounds on TeV-scale gravity can be obtained from the absence of neutrino cosmic ray showers mediated by black holes. However, uncertainties in the cross section of black hole formation and, most importantly, large uncertainties in the neutrino flux affects these bounds. As long as the cosmic neutrino flux remains unknown, the non-observation of neutrino induced showers implies less stringent limits than present collider limits.Comment: Changes to match published versio

Predictors of Influenza Vaccination Uptake and the Role of Health Literacy among Health and Social Care Volunteers in the Province of Prato (Italy)

Annual influenza vaccination is recommended for volunteers involved in primary health and social services. Little is known about the volunteers’ adhesion to influenza vaccination recommendations. The aim of this study was to assess influenza vaccination determinants among a group of volunteers who provided essential activities during the first SARS-CoV-2 pandemic wave in the province of Prato, Tuscany (Italy) and to evaluate the role of health literacy in influencing vaccination determinants. Method: In this cross-sectional study, the predictors of influenza vaccination uptake were assessed through the administration of a questionnaire. Variables significantly associated with influenza vaccination uptake were included in five multivariate logistic regression models through a backward stepwise procedure. Results: Among the 502 enrolled volunteers, 24.3% reported being vaccinated in the 2019–2020 season. Vaccination uptake was 48.8% in participants aged 65 years or older and 15.7% in those aged 64 years or younger. Considering the whole sample in the final model of multivariate logistic regression analysis, the predictors of influenza vaccination uptake were age (OR = 1.05; 95% CI = 1.03–1.07), presence of heart diseases (OR = 2.98; 95% CI = 1.24–7.19), pulmonary diseases (OR = 6.18; 95% CI = 2.01–19.04) and having undergone surgery under general anesthesia in the prior year (OR = 3.14; 95% CI = 1.23–8.06). In the multivariate model considering only participants with a sufficient level of health literacy (HL), none of these predictors resulted in significant associations with vaccination uptake, except for age (OR= 1.04; 95% CI = 1.02–1.07). Conclusions: Our findings revealed a very low influenza vaccination uptake among volunteers, suggesting the need to increase awareness in this at-risk group by means of a better communication approach

Active Galactic Nuclei in Groups and Clusters of Galaxies: Detection and Host Morphology

The incidence and properties of Active Galactic Nuclei (AGN) in the field, groups, and clusters can provide new information about how these objects are triggered and fueled, similar to how these environments have been employed to study galaxy evolution. We have obtained new XMM-Newton observations of seven X-ray selected groups and poor clusters with 0.02 < z < 0.06 for comparison with previous samples that mostly included rich clusters and optically-selected groups. Our final sample has ten groups and six clusters in this low-redshift range (split at a velocity dispersion of $\sigma = 500$ km/s). We find that the X-ray selected AGN fraction increases from $f_A(L_X>10^{41}; M_R<M_R^*+1) = 0.047^{+0.023}_{-0.016}$ in clusters to $0.091^{+0.049}_{-0.034}$ for the groups (85% significance), or a factor of two, for AGN above an 0.3-8keV X-ray luminosity of $10^{41}$ erg/s hosted by galaxies more luminous than $M_R^*+1$. The trend is similar, although less significant, for a lower-luminosity host threshold of $M_R = -20$ mag. For many of the groups in the sample we have also identified AGN via standard emission-line diagnostics and find that these AGN are nearly disjoint from the X-ray selected AGN. Because there are substantial differences in the morphological mix of galaxies between groups and clusters, we have also measured the AGN fraction for early-type galaxies alone to determine if the differences are directly due to environment, or indirectly due to the change in the morphological mix. We find that the AGN fraction in early-type galaxies is also lower in clusters $f_{A,n>2.5}(L_X>10^{41}; M_R<M_R^*+1) = 0.048^{+0.028}_{-0.019}$ compared to $0.119^{+0.064}_{-0.044}$ for the groups (92% significance), a result consistent with the hypothesis that the change in AGN fraction is directly connected to environment.Comment: 18 pages, 9 figures; accepted by The Astrophysical Journal; for higher-resolution versions of some figures, see http://u.arizona.edu/~tjarnold/Arnold09

Antibacterial Properties of Bacterial Endophytes Isolated from the Medicinal Plant Origanum heracleoticum L

Background: Bacterial endophytic communities associated with medicinal plants synthesize a plethora of bioactive compounds with biological activities. Their easy isolation and growth procedures make bacterial endophytes an untapped source of novel drugs, which might help to face the problem of antimicrobial resistance. This study investigates the antagonistic potential of endophytic bacteria isolated from different compartments of the medicinal plant O. heracleoticum against human opportunistic pathogens. Methods: A panel of endophytes was employed in cross-streaking tests against multidrug-resistant human pathogens, followed by high-resolution chemical profiling using headspace-gas chromatography/mass spectrometry. Results: Endophytic bacteria exhibited the ability to antagonize the growth of opportunistic pathogens belonging to the Burkholderia cepacia complex (Bcc). The different inhibition patterns observed were related to their taxonomic attribution at the genus level; most active strains belong to the Gram-positive genera Bacillus, Arthrobacter, and Pseudarthrobacter. Bcc strains of clinical origin were more sensitive than environmental strains. Cross-streaking tests against other 36 human multidrug-resistant pathogens revealed the highest antimicrobial activity towards the Coagulase-negative staphylococci and Klebsiella pneumoniae strains. Interestingly, strains of human origin were the most inhibited, in both groups. Concerning the production of volatile organic compounds (VOCs), the strain Arthrobacter sp. OHL24 was the best producer of such compounds, while two Priestia strains were good ketones producers and so could be considered for further biotechnological applications. Conclusions: Overall, this study highlights the diverse antagonistic activities of O. heracleoticum-associated endophytes against both Bcc and multidrug-resistant (MDR) human pathogens. These findings hold important implications for investigating bacterial endophytes of medicinal plants as new sources of antimicrobial compounds