11 research outputs found
Sialyl Lewis X-Carboxymethylpullulan Conjugate: A Novel Homing Device to Spleen and Lymph Nodes
Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region
A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands
Distribution of MGL1 Binding Sites and MGL1/2-positive Cells in Lymph Nodes during the Sensitization Phase of Contact Hypersensitivity
Siglec-mediated regulation of immune cell function in disease
All mammalian cells display a diverse array of glycan structures that differ from those found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin-like receptors that participate in the discrimination of âselfâ and ânon-selfâ and regulate the functions of cells in the innate and adaptive immune systems through recognition of their glycan ligands. In this review, we describe the recent advances in our understanding of the roles of Siglecs in the regulation of immune cell functions in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer