99 research outputs found
Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes
BACKGROUND: Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population. METHODS: Eleven variants selected by a candidate gene approach capturing the common and low-frequency variation of AGPAT6 were genotyped in 12,068 Danes from four study populations of middle-aged individuals. The case–control study involved 4,638 type 2 diabetic and 5,934 glucose-tolerant individuals, while studies of quantitative metabolic traits were performed in 5,645 non-diabetic participants of the Inter99 Study. RESULTS: None of the eleven AGPAT6 variants were robustly associated with type 2 diabetes in the Danish case–control study. Moreover, none of the AGPAT6 variants showed association with measures of obesity (waist circumference and BMI), serum lipid concentrations, fasting or 2-h post-glucose load levels of plasma glucose and serum insulin, or estimated indices of insulin secretion or insulin sensitivity. CONCLUSIONS: Common and low-frequency variants in AGPAT6 do not significantly associate with type 2 diabetes susceptibility, or influence related phenotypic traits such as obesity, dyslipidemia or indices of insulin sensitivity or insulin secretion in the population studied
Recent Results from the BRAHMS Experiment
We present recent results obtained by the BRAHMS experiment at the
Relativistic Heavy Ion Collider (RHIC) for the systems of Au + Au and Cu + Cu
at \rootsnn{200} and at 62.4 GeV, and p + p at \rootsnn{200}. Nuclear
modification factors for Au + Au and Cu + Cu collisions are presented. Analysis
of anti-particle to particle ratios as a function of rapidity and collision
energy reveal that particle populations at the chemical freeze-out stage for
heavy-ion reactions at and above SPS energies are controlled by the baryon
chemical potential. From the particle spectra we deduce significant radial
expansion ( 0.75), as expected for systems created with a large
initial energy density. We also measure the elliptic flow parameter
versus rapidity and \ptn. We present rapidity dependent ratios within
for Au + Au and Cu + Cu at \rootsnn{200}. \Raa is found to increase
with decreasing collision energy, decreasing system size, and when going
towards more peripheral collisions. However, \Raa shows only a very weak
dependence on rapidity (for ), both for pions and protons.Comment: 16 pages and 14 figures, proceedings for plenary talk at Quark Matter
2005, Budapest, Hungar
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