8 research outputs found
Myositis Ossificans Circumscripta Without History of Trauma
Myositis ossificans circumscripta is a form of heterotopic ossification that is benign in nature associated to a trauma, but may appear clinically and radiologically as a malignant neoplasm. We describe a rare case of calcifying of myositis ossificans not associated to trauma in a 35-year-old woman with a mass in her upper third and external of right thigh. We discuss some of the difficulties of diagnosis and histological evolution of the lesion
Smoothelin and WT-1 expression in glomus tumors and glomuvenous malformations
Background: Smoothelin is a specific marker
for smooth muscle cells with contractile capacity which
has not been widely studied in glomus lesions. In the
same way, the expression for Wilms tumor 1 (WT1) has
only been studied occasionally in the endothelial cells of
glomovenous malformations and in the glomus cells of
glomus tumours. Objective: We studied the significance
of immunohistochemical expression of smoothelin and
WT1 in 25 glomus lesions. Methods: We assessed 9
cases of solid glomus tumors (SGT), 8 cases of glomus
tumors with vascular ectasia (VEGT), 2 cases of
glomangiomyomas (GMM) and 6 cases of glomuvenous
malformation (GM). Immunohistochemistry was
performed, evaluating the expression of WT1,
smoothelin, smooth muscle actin (SMA), smooth muscle
myosin (SMM), h-caldesmon and desmin. Results:
Glomic cells showed cytoplasmic positivity for
smoothelin, and WT1 expression was present in all
studied cases. SGT showed WT1 positivity in all
endothelia. However, in regarding VEGT and GMM,
WT1 endothelial expression was positive in some areas,
but not in others. GM did not show endothelial cell
positivity for WT1. Conclusions: Smoothelin expression
in glomic cells indicates that they are contractile smooth
muscle cells, and thus its role in routine diagnosis should
be considered. The absence of WT1 expression in the
endothelium of the vascular structures of the GM is a
differential characteristic between SGT, VEGT and
GMM
A pregnant woman with a nodule on the tongue: a quiz. Lobular capillary haemangioma (pyogenic granuloma)
Diagnosis: Lobular capillary haemangioma (pyogenic granuloma)A 34-year-old woman, in her fourth month of pregnancy, presented with an isolated exophytic lesion of the tongue, which had developed 2 months previously and which caused discomfort when swallowing.Ye