2 research outputs found
Evaluation of hepatoprotective activity of stem bark of Pterocarpus marsupium Roxb.
OBJECTIVE : To evaluate the hepatoprotective activity of Pterocarpus
marsupium stem bark extracts against carbon tetrachloride
(CCl4)-induced hepatotoxicity. MATERIALS AND METHODS : Hepatotoxicity
was induced in male Wistar rats by intraperitoneal injection of CCl4
(0.1 ml/kg/day for 10 days). Methanol and aqueous extracts of P.
marsupium stem bark were administered to the experimental rats (25
mg/kg/day, p.o. for 14 days). The hepatoprotective effect of these
extracts was evaluated by the assay of liver function biochemical
parameters (total bilirubin, serum protein, alanine aminotransaminase,
aspartate aminotransaminase, and alkaline phosphatase activities) and
histopathological studies of the liver. RESULTS : In methanol
extract-treated animals, the toxic effect of CCl4 was controlled
significantly by restoration of the levels of serum bilirubin, protein
and enzymes as compared to the normal and the standard drug
silymarin-treated groups. Histology of the liver sections of the
animals treated with the extracts showed the presence of normal hepatic
cords, absence of necrosis and fatty infiltration, which further
evidenced the hepatoprotective activity. CONCLUSION : Methanol extract
of the stem bark of P. marsupium possesses significant
hepatoprotective activity