175 research outputs found
Imaging and Imagining Taiwan: Identity representation and cultural politics
Since the 1990s the issue of identity has been one of the most prominent and hotly-debated topics in Taiwan Studies. A rich corpus of literature has been produced in various fields in the attempt to address this problematic issue, examining questions of Taiwanese identity from political, social and cultural perspectives. Imaging and Imagining Taiwan takes a fresh approach to this important topic, examining Taiwanese identity from a visual perspective and exploring the ways in which the island is presented and imagined. In contrast to those studies that seek to address the issue of identity from an essentialist position, Imaging and Imagining Taiwan offers a new contextualization of identity, investigating the ways in which Taiwan has been represented in films, fine art, advertising, sport, and social spaces at different periods in history. Covering a diverse range of topics, the book aims to capture the fluidity, changeability, fragmentation and dynamism of Taiwanese identity as an imaginary and encompassing whole. Through seven case studies the book focuses on the ways in which Taiwan is represented, how this relates to identity politics, and how the island is imaged and imagined visually, socially, and symbolically. The essays comprising this collection are grouped into three sections, each of which focuses on a particular approach to the topic of Taiwanese identity. The first of these —Colonial Representation —deals with colonial subjectivity and traumatic experience. The second, entitled Imaging Difference, examines cultural practices in film, TV advertisements and fine art, and explores the boundaries between the inside and the outside, the difference marked by the process of othering, and the anxiety and alienation of the excluded. The third section—Identity and Place—focuses on the relationship between identity and the social construction of place, and examines the role of place-making in the new Taiwanese nation-building process. Interrogating the complex issue of Taiwanese identity from various standpoints, the seven contributors write from a range of disciplinary backgrounds (Literature, History, Film Studies, Linguistics, Anthropology and Cultural Studies) and geographical contexts (Taiwan, Europe and America). This combination of fresh perspectives and a range of disciplinary approaches offers a set of diverse yet complementary insights into how Taiwan has been envisioned and imagined, and how the Taiwanese have positioned and identified themselves at different times. By combining different themes and disciplinary approaches together in one publication, Imaging and Imagining Taiwan brings both nuance and depth to the discussion of the representation of Taiwanese identity. The book articulates and examines the complexity of identity, avoiding essentialist approaches to the topic, instead illustrating identity's multi-faceted nature and dynamic messiness. Thus, the book argues, the politics of identity is not only a politics of representation, but also a politics of positioning, whereby identity is formulated both by the construction of sameness and the inscription of difference. The interdisciplinary approach adopted by this book makes the discussion of Taiwanese identity of interest to those both studying and working in a range of subject disciplines, not limited to Taiwan Studies, but also in History, Film, Linguistics, Literary Studies, Nationalism Studies, and Urban Studies
Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells.
FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans. Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer. Herein, we investigated the roles of FUT1 and FUT2 in breast cancer. Silencing of FUT1 or FUT2 by shRNAs inhibited cell proliferation in vitro and tumorigenicity in mice. This was associated with diminished properties of cancer stem cell (CSC), including mammosphere formation and CSC marker both in vitro and in xenografts. Silencing of FUT2, but not FUT1, significantly changed the cuboidal morphology to dense clusters of small and round cells with reduced adhesion to polystyrene and extracellular matrix, including laminin, fibronectin and collagen. Silencing of FUT1 or FUT2 suppressed cell migration in wound healing assay, whereas FUT1 and FUT2 overexpression increased cell migration and invasion in vitro and metastasis of breast cancer in vivo. A decrease in mesenchymal like markers such as fibronectin, vimentin, and twist, along with increased epithelial like marker, E-cadherin, was observed upon FUT1/2 knockdown, while the opposite was noted by overexpression of FUT1 or FUT2. As expected, FUT1 or FUT2 knockdown reduced Globo H, whereas FUT1 or FUT2 overexpression showed contrary effects. Exogenous addition of Globo H-ceramide reversed the suppression of cell migration by FUT1 knockdown but not the inhibition of cell adhesion by FUT2 silencing, suggesting that at least part of the effects of FUT1/2 knockdown were mediated by Globo H. Our results imply that FUT1 and FUT2 play important roles in regulating growth, adhesion, migration and CSC properties of breast cancer, and may serve as therapeutic targets for breast cancer
On the importance of interface stability in cellular automata models: Planar and dendritic solidification in laser melted YSZ
Laser-processing technologies are often applied to enhance the properties of ceramics, such as laser glazing of Yttria Stabilised Zirconia (YSZ). However, very limited attention was paid to the solidification phenomena and mechanisms of YSZ. In this paper, two coexisting solidification behaviours of laser-melted YSZ have been identified, namely grain bending (crystals with curved grain boundary geometry under the surface) and grain surface sealing (in-plane surficial crystals cover vertical columnar grains). Although these phenomena have been reported, this is the first time the two phenomena coexist in the same material. A new cellular automata (CA) approach has been proposed to explain the formation mechanisms of these two phenomena. This new CA method consists of the separation of growth modes into dendritic and planar growth, whose critical transition value is calculated based on the supercooling theory. Besides, the proposed model for planar growth is far less computationally expensive than the widely used decentred octahedron algorithm. A good agreement with the EBSD data of longitudinal cross-sections and the top surface has been observed which proves that the proposed method can become a more realistic and efficient way to predict the grain microstructure in laser processing, allowing to capture dendritic and planar growth simultaneously
Global analysis of the relationship between reconstructed solar induced chlorophyll fluorescence (SIF) and gross primary production (GPP)
Solar-induced chlorophyll fluorescence (SIF) is increasingly known as an effective proxy for plant photosynthesis, and therefore, has great potential in monitoring gross primary production (GPP). However, the relationship between SIF and GPP remains highly uncertain across space and time. Here, we analyzed the SIF (reconstructed, SIFc)–GPP relationships and their spatiotemporal variability, using GPP estimates from FLUXNET2015 and two spatiotemporally contiguous SIFc datasets (CSIF and GOSIF). The results showed that SIFc had significant positive correlations with GPP at the spatiotemporal scales investigated (p p p > 0.05). Therefore, we propose a two-slope scheme to differentiate ENF from non-ENF biome and synopsize spatiotemporal variability of the GPP/SIFc slope. The relative biases were 7.14% and 11.06% in the estimated cumulative GPP across all EC towers, respectively, for GOSIF and CSIF using a two-slope scheme. The significantly higher GPP/SIFc slopes of the ENF biome in the two-slope scheme are intriguing and deserve further study. In addition, there was still considerable dispersion in the comparisons of CSIF/GOSIF and GPP at both site and biome levels, calling for discriminatory analysis backed by higher spatial resolution to systematically address issues related to landscape heterogeneity and mismatch between SIFc pixel and the footprints of flux towers and their impacts on the SIF–GPP relationship
White rice consumption and risk of esophageal cancer in Xinjiang Uyghur Autonomous Region, northwest China: a case-control study
This study investigated the association between white rice consumption and the risk of esophageal cancer in remote northwest China, where the cancer incidence is known to be high. A case-control study was conducted during 2008-2009 in Urumqi and Shihezi, Xinjiang Uyghur Autonomous Region of China. Participants were 359 incident esophageal cancer patients and 380 hospital-based controls. Information on habitual white rice consumption was obtained by personal interview using a validated semi-quantitative food frequency questionnaire. Logistic regression analyses were performed to assess the association between white rice consumption and the esophageal cancer risk. Confounding variables including socio-demographics, family history, dietary and lifestyle factors were adjusted in the multivariate model. The esophageal cancer patients reported lower consumption levels of white rice-based products, including cooked white rice and porridge, when compared to the control group. Overall, regular consumption of white rice foods was inversely associated with the esophageal cancer risk, the adjusted OR being 0.34 (95Â % CI 0.23 to 0.52) for the highest (>250Â g) versus the lowest (<92Â g) tertile of daily intake. Similar reductions in risk were also apparent for high consumption levels of cooked white rice and porridge. In conclusion, habitual white rice consumption was associated with a reduced risk of esophageal cancer for adults residing in northwest China. Our findings provide evidence to support the continued consumption of white rice
Ecosystem Carbon Stock Influenced by Plantation Practice: Implications for Planting Forests as a Measure of Climate Change Mitigation
Uncertainties remain in the potential of forest plantations to sequestrate carbon (C). We synthesized 86 experimental studies with paired-site design, using a meta-analysis approach, to quantify the differences in ecosystem C pools between plantations and their corresponding adjacent primary and secondary forests (natural forests). Totaled ecosystem C stock in plant and soil pools was 284 Mg C ha−1 in natural forests and decreased by 28% in plantations. In comparison with natural forests, plantations decreased aboveground net primary production, litterfall, and rate of soil respiration by 11, 34, and 32%, respectively. Fine root biomass, soil C concentration, and soil microbial C concentration decreased respectively by 66, 32, and 29% in plantations relative to natural forests. Soil available N, P and K concentrations were lower by 22, 20 and 26%, respectively, in plantations than in natural forests. The general pattern of decreased ecosystem C pools did not change between two different groups in relation to various factors: stand age (<25 years vs. ≥25 years), stand types (broadleaved vs. coniferous and deciduous vs. evergreen), tree species origin (native vs. exotic) of plantations, land-use history (afforestation vs. reforestation) and site preparation for plantations (unburnt vs. burnt), and study regions (tropic vs. temperate). The pattern also held true across geographic regions. Our findings argued against the replacement of natural forests by the plantations as a measure of climate change mitigation
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