8 research outputs found
Experience of Racism as a Correlate of Developmental and Health Outcomes Among Urban Adolescent Mental Health Clients
A theoretical framework for understanding ethnic socialization among international adoptees
10.1606/1044-3894.3817Families in Society894543-55
Transracial Adoption by Lesbian, Gay, and Heterosexual Couples: Who Completes Transracial Adoptions and With What Results?
Accelerated fetal lung maturation by estrogen is associated with an epithelial-fibroblast interaction
Race Lessons in Black and White: How White Adoptive Parents Socialize Black Adoptees in Predominately White Communities
Postnatal lung function after prenatal steroid treatment in sheep: Effect of gender
The effect of fetal gender on postnatal lung function and response to prenatal steroid exposure were examined retrospectively in a group of 115 preterm lambs. Fetuses received a single intramuscular injection of 0.5 mg/kg betamethasone alone or in conjunction with L-thyroxine 48 h before delivery at 128-d gestational age. Control animals received an equivalent volume of saline. After delivery, respiratory mechanics and blood gas parameters were recorded for 40 min. Deflation pressure volume curves were constructed in excised lungs. Right upper lobes from a randomly selected subgroup of control animals were examined morphometrically. Control (saline-treated) females were able to be ventilated at lower ventilatory pressures with equivalent tidal volumes and more efficient gas exchange. There were no gender differences in compliance, conductance, or excised lung volumes for saline-treated animals. More efficient gas exchange in females could not be explained by thinner alveolar septa or greater alveolar surface area. After hormone treatment, both males and females exhibited significant improvements in respiratory mechanics, gas exchange, and an increase in alveolar surfactant concentration. However, females exhibited a significantly greater improvement than males for compliance, conductance, excised lung volume, and arterial oxygen partial pressure. These data provide a comprehensive description of gender differences in postnatal lung function and response to steroid treatment in preterm animals, and support clinical findings of sexual dimorphism