Ferrocenyl-coupled n-heterocyclic carbene complexes of gold(i): a successful approach to multinuclear anticancer drugs

Four gold(I) carbene complexes featuring 4-ferrocenyl substituted imidazol-2-ylidene ligands were investigated for antiproliferative and antivascular properties. They were active against a panel of seven cancer cell lines, including multidrug-resistant ones, with low micromolar or nanomolar IC50 (72 h) values, according to their lipophilicity and cellular uptake. The delocalised lipophilic cationic complexes 8 and 10 acted by increasing the reactive oxygen species in two ways: via a genuine ferrocene effect and by inhibiting the thioredoxin reductase. Both complexes gave rise to a reorganization of the F-actin cytoskeleton in endothelial and melanoma cells, associated with a G1 phase cell cycle arrest and a retarded cell migration. They proved antiangiogenic in tube formation assays with endothelial cells and vascular-disruptive on real blood vessels in the chorioallantoic membrane of chicken eggs. Biscarbene complex 10 was also tolerated well by mice where it led to a volume reduction of xenograft tumors by up to 80%

The role of tourism in local economy development. Bihor County case study

The purpose of the present study is to emphasize the role of tourism in local economy development, in the context of present-day society dominated by antagonistic battles between local/regional values and the global ones. Tourism is a special anthropic activity, with deep implications both in the spatial individuality and regional values assertion and in those with global character. It sets up for a significant indicator regarding the development level recorded by a human collectivity in a certain area. In this context, the results of the correlations between the number of companies, employees, turnover and recorded profit, during the period between 2000 and 2014, on spatial and global level, become significant indicators, having special relevance in the role and importance of tourism in local economy development

Determining forest fund evolution by fractal analysis (Suceava-Romania)

The main objective of this study is developing an analysis methodology for the forest fund dynamic. One of the most severe current issues which Romania faces is the extent of deforestation, under the pressure of economic activities, also affecting forest areas. The Global Forest Change 2000-2013 data, supplied by Maryland University, was used for the analyses conducted, being further subjected to a segmentation process, using the Colour Deconvolution plug-in of ImageJ 1.49s. The segmented images have been manually binarized, and based on the latter, the covered areas have been further calculated and expressed in km2. For this purpose, a macro was written, implemented in ImageJ 1.49s. The resulting binarized images have been fractal analyzed, using the software ImageJ 1.49s - FracLac 2015Mar6206 - Box-counting Fractal and Lacunarity Analysis. ArcGIS platform was used to draft the cartographic materials, justifying and supporting this study. The main results of this study comprise of the alarming increase in deforested areas and the large difference between official data and statistical data reported from the real field situation, which illustrates the high extent of illegal logging, reached lately. Coherent strategies for territorial management are highly required to reduce, halt and even fight against these illicit activities

CCDC 1500972: Experimental Crystal Structure Determination

Related Article: Julienne K. Muenzner, Bernhard Biersack, Alexander Albrecht, Tobias Rehm, Ulrike Lacher, Wolfgang Milius, Angela Casini, Jing-Jing Zhang, Ingo Ott, Viktor Brabec, Olga Stuchlikova, Ion C. Andronache, Leonard Kaps, Detlef Schuppan, Rainer Schobert|2016|Chem.-Eur.J.|22|18953|doi:10.1002/chem.201604246,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.