Regulation of inhomogeneous drilling model with a P-I controller

International audienceIn this paper, we demonstrate that a Proportional Integral controller allows the regulation of the angular velocity of a drill-string despite unknown frictional torque and measuring only the angular velocity at the surface. Our model is an one dimensional damped inhomogeneous wave equation subject to an unknown dynamic at one side while the control and the measurement are in the other side. After writing this system of balance laws into the Riemann coordinates, we design a Lyapunov functional to prove the exponential stability of the closed-loop and show how it implies the regulation of the angular velocity

A new scoring system for the diagnosis of BRCA1/2 associated breast-ovarian cancer predisposition.

International audienceCriteria have been proposed for genetic testing of breast and ovarian cancer susceptibility genes BRCA1 and BRCA2. Using simulations, this study evaluates the efficiency (sensitivity, positive predictive value [PPV] and specificity) of the various criteria used in France. The efficiency of the criteria published in 1998, which are largely used, is not optimal. We show that some extensions of these criteria provide an increase in sensitivity with a low decrease in specificity and PPV. The study shows that scoring systems (Manchester, Eisinger) have similar efficiency that may be improved. In this aim, we propose a new scoring system that takes into account unaffected individuals and kinship coefficients between family members. This system increases sensitivity without affecting PPV and specificity. Finally, we propose a two-step procedure with a large screening by the physician for recommending genetic counselling, followed by a more stringent selection by the geneticist for prescribing genetic testing. This procedure would result in an increase of genetic counselling activity but would allow the identification of almost 80% of mutation carriers among affected individuals, with a mutation detection rate of 15% and a specificity of 88%

Stress corrosion crack initiation of Zircaloy-4 cladding tubes in an iodine vapor environment during creep, relaxation, and constant strain rate tests

During accidental power transient conditions with Pellet Cladding Interaction (PCI), the synergistic effect of the stress and strain imposed on the cladding by thermal expansion of the fuel, and corrosion by iodine released as a fission product, may lead to cladding failure by Stress Corrosion Cracking (SCC). In this study, internal pressure tests were conducted on unirradiated cold-worked stress-relieved Zircaloy-4 cladding tubes in an iodine vapor environment. The goal was to investigate the influence of loading type (constant pressure tests, constant circumferential strain rate tests, or constant circumferential strain tests) and test temperature (320, 350, or 380 °C) on iodine-induced stress corrosion cracking (I-SCC). The experimental results obtained with different loading types were consistent with each other. The apparent threshold hoop stress for I-SCC was found to be independent of the test temperature. SEM micrographs of the tested samples showed many pits distributed over the inner surface, which tended to coalesce into large pits in which a microcrack could initiate. A model for the time-to-failure of a cladding tube was developed using finite element simulations of the viscoplastic mechanical behavior of the material and a modified Kachanov's damage growth model. The times-to-failure predicted by this model are consistent with the experimental data

Precipitation changes in the Mediterranean basin during the Holocene from terrestrial and marine pollen records: a model–data comparison

Climate evolution of the Mediterranean region during the Holocene exhibits strong spatial and temporal variability. The spatial differentiation and temporal variability, as evident from different climate proxy datasets, has remained notoriously difficult for models to reproduce. In light of this complexity, we examine the previously described evidence for (i) opposing northern and southern precipitation regimes during the Holocene across the Mediterranean basin, and (ii) an east-to-west precipitation gradient or dipole during the early Holocene, from a wet eastern Mediterranean to dry western Mediterranean. Using quantitative climate information from marine and terrestrial pollen archives, we focus on two key time intervals, the early to mid-Holocene (8000 to 6000 cal yrs BP) and the late Holocene (4000 to 2000 yrs BP), in order to test the above mentioned hypotheses on a Mediterranean-wide scale. Palynologically derived climate information is compared with the output of regional-scale climate-model simulations for the same time intervals. Quantitative pollen-based precipitation estimates were generated along a longitudinal gradient from the Alboran (West) to the Aegean Sea (East); they are derived from terrestrial pollen records from Greece, Italy and Malta as well as from pollen records obtained from marine cores. Because seasonality represents a key parameter in Mediterranean climates, special attention was given to the reconstruction of season-specific climate information, notably summer and winter precipitation. The reconstructed climatic trends corroborate a previously described north-south partition of precipitation regimes during the Holocene. During the early Holocene, relatively wet conditions occurred in the south-central and eastern Mediterranean region, while drier conditions prevailed from 45° N northwards. These patterns reversed during the late Holocene, with a wetter northern Mediterranean region and drier conditions in the east and south. More sites from the northern part of the Mediterranean basin are needed to further substantiate these observations. With regard to the existence of a west-east precipitation dipole during the Holocene, our pollen-based climate data show that the strength of this dipole is strongly linked to the seasonal parameter reconstructed: Early Holocene summers show a clear east-to-west gradient, with summer precipitation having been highest in the central and eastern Mediterranean and lowest over the western Mediterranean. In contrast, winter precipitation signals are less spatially coherent. A general drying trend occurred from the early to the late Holocene; particularly in the central and eastern Mediterranean. However, summer precipitation in the east remained above modern values, even during the late Holocene interval. Pollen-inferred precipitation estimates were compared to regional-scale climate modelling simulations based on the HadAM3 GCM coupled to the dynamic HadSM3 and the high-resolution regional HadRM3 models. Climate model outputs and pollen-inferred precipitation estimates show remarkably good overall correspondence, although many simulated patterns are of marginal statistical significance. Nevertheless, models weakly support an east to west division in summer precipitation and there are suggestions that the eastern Mediterranean experienced wetter summer and winter conditions during the early Holocene and wetter summer conditions during the late Holocene. The extent to which summer monsoonal precipitation may have existed in the southern and eastern Mediterranean during the mid-Holocene remains an outstanding question; our model, consistent with other global models, does not suggest an extension of the African monsoon into the Mediterranean. Given the difficulty in modelling future climate change in Southern Europe, more simulations based on high resolution global models and very high resolution regional downscaling, perhaps even including transient simulations, are required to fully understand the patterns of change in winter and summer circulation patterns over the Mediterranean regio

Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations

In a French national cohort of unaffected females carriers/non-carriers of a BRCA1/2 mutation, long-term preventive strategies and breast/ovarian cancer risk perceptions were followed up to 5 years after test result disclosure, using self-administered questionnaires. Response rate was 74%. Carriers (N=101) were younger (average age±SD=37±10) than non-carriers (N=145; 42±12). There were four management strategies that comprised 88% of the decisions made by the unaffected carriers: 50% opted for breast surveillance alone, based on either magnetic resonance imaging (MRI) and other imaging (31%) or mammography alone (19%); 38% opted for either risk reducing salpingo-oophorectomy (RRSO) and breast surveillance, based on MRI and other imaging (28%) or mammography alone (10%). The other three strategies were: risk reducing mastectomy (RRM) and RRSO (5%), RRM alone (2%) and neither RRM/RRSO nor surveillance (6%). The results obtained for various age groups are presented here. Non-carriers often opted for screening despite their low cancer risk. Result disclosure increased carriers' short-term high breast/ovarian cancer risk perceptions (P⩽0.02) and decreased non-carriers' short- and long-term perceptions (P<0.001). During follow-up, high breast cancer risk perceptions increased with time among those who had no RRM and decreased in the opposite case; high ovarian cancer risk perceptions increased further with time among those who had no RRSO and decreased in the opposite case; RRSO did not affect breast cancer risk perceptions. Informed decision-making involves letting women know whether opting for RRSO and breast MRI surveillance is as effective in terms of survival as RRM and RRSO