ПРИМЕНЕНИЕ ПАКЕТА MATHCAD В МНОГОМЕРНОМ АНАЛИЗЕ ВЗАИМОСВЯЗЕЙ МИРОВЫХ ФОНДОВЫХ РЫНКОВ

Computer programs for analytical studies and forecasting of economic phenomena and processes are the everyday operating tool of a modern expert associated with the processing of statistical information. The program "SEMESTR" created on the base of Mathcad provides the wide range of possibilities for the comprehension of these algorithms due to automation of the multivariate data processing. Its usage in the educational process allows to develop stable skills in applying of mathematical and statistical methods of data analysis.Компьютерные программы для аналитических исследований и прогнозирования экономичес-ких явлений и процессов по праву являются повседневным рабочим инструментом совре-менного специалиста, связанного с обработкой статистической информации. Широкие воз-можности для изучения алгоритмов их работы предоставляет программа «SEMESTR» для пакета Mathcad, предназначенная для автома-тизации обработки данных на основе методов многомерного анализа. Ее использование в учебном процессе позволяет сформировать устойчивые навыки применения математико-статистических методов анализа данны

МЕТОДИЧЕСКИЕ ПОДХОДЫ К ИССЛЕДОВАНИЮ МНОГОМЕРНЫХ ЗАВИСИМОСТЕЙ НА ПРИМЕРЕ ФОНДОВОГО РЫНКА

Many-dimensional nature of real occurences and processes explains the actually increasing interest to the multivariate statistical analysis as a sophisticated toolset of the advanced researcher. Within the framework of the annual course «Multivariate statistical methods» such subsections as «Multivariate regression analysis», «Methods of the reduction of the variable space dimensionality», «Multivariate classification» are taught. All theoretical foundations are supported by praxis in computer class. The Mathcad based program «SEMESTR» provides the wide range of possibilities for performing laboratory works by course due to automation of the multivariate data processing. The article is devoted to the methodical principles of the study of multivariate relations between stock indexes.Многопризнаковая природа реальных явлений и процессов объясняет постоянно возрастающий интерес к методам многомерного статистического анализа, которые по праву являются интеллектуальным инструментарием современного исследователя. В рамках годового курса «Многомерные статистические методы» традиционно рассматриваются такие основные разделы как «Множественный корреляционно-регрессионный анализ», «Методы снижения размерности», «Методы многомерной классификации». Теоретический материал сопровождаются практическими занятиями в компьютерном классе. Широкие возможности для выполнения предусмотренных курсом лабораторных работ предоставляет программа «SEMESTR» для пакета Mathcad, предназначенная для автоматизации обработки данных на основе методов многомерного анализа. В статье излагаются методические основы исследования многомерных взаимосвязей на примере фондовых индексов

Clathrate Hydrates of Organic Solvents as Auxiliary Intermediates in Pharmaceutical Research and Development: Improving Dissolution Behaviour of a New Anti-Tuberculosis Drug, Perchlozon

There is an urgent need for new drugs to overcome the challenge of the ever-growing drug resistance towards tuberculosis. A new, highly efficient anti-tuberculosis drug, Perchlozone (thioureidoiminomethylpyridinium perchlorate, Pz), is only available in an oral dosage form, though injectable forms and inhalation solutions could be better alternatives, offering higher bioavailability. To produce such forms, nano- and micro-particles of APIs would need to be prepared as dispersions with carriers. We use this case study to illustrate the principles of selecting solvents and excipients when preparing such formulations. We justify the choice of water–THF (19.1 wt % THF) as solvent and mannitol as carrier to prepare formulations of Pz—a poorly soluble compound—that are suitable for injection or inhalation. The formulations could be prepared by conventional freeze-drying in vials, making the proposed method suitable for industrial scaling. A similar strategy for selecting the organic solvent and the excipient can be applied to other compounds with low water solubility

A New Approach for the Synthesis of 2,3,4а,6,7,8а,9,10-Octaaza-4,8-dioxo-3,4,4a,7,8,8а,9,9a,10,10а-decahydroanthracene and High-Energy Performance Characterization of Its Dinitramide Salt

A simple, one-pot regioselective method for the synthesis of a high-nitrogen tricycle, 2,3,4а,6,7,8а,9,10-octaaza-4,8-dioxo-3,4,4a,7,8,8а,9,9a,10,10а-decahydroanthracene, with a yield of 27% was developed on a starting urea basis as a result of studies focused on finding new, more efficient approaches to the synthesis of high-energy derivatives of dinitramic acid (DNA). This tricycle was further treated to furnish 2,3,4а,6,7,8а,9,10-octaaza-4,8-dioxo-3,4,4a,7,8,8а,9a,10а-octohydroanthracene-9,10-ion-bis(dinitramide). The resultant salt of dinitramic acid exhibited inhibitory properties towards the burning rate of pyrotechnic compositions, reducing it by 30%, and possessed good thermal stability due to a high decomposition temperature above 260 °C and a low sensitivity to mechanical stimuli. The structural features of the new tricycle-based dinitramide salt were characterized via 2D NMR spectroscopy and double-focusing sector mass spectrometry (DFS)

Adducts of the Zinc Salt of Dinitramic Acid

Herein, we describe the synthesis of coordination compounds starting from carbohydrazide ((H2NHN)2C=O (CHZ)) and the Zn2+ salt of dinitramic acid (HDN), which are high-nitrogen substances that exhibit properties similar to those of a burning-rate inhibitor of pyrotechnic compositions. This study demonstrates that these compounds react with glyoxal to furnish adducts of metal–organic macrocyclic cages bearing the elements of carbohydrazide, complexing metals and the HDN anion, depending on the ratio of the starting reactants. The assembled macrocyclic cage has “host–guest” properties and is a safe container for the storage of HDN salts. X-ray crystallographic analysis of the resultant coordination compound, [Zn(chz)3(N(NO2)2)2]), indicated that the metal–ligand association occurs via the N and O atoms of carbohydrazide. The zinc salt of dinitramic acid, which is enclosed into adducts with a macrocycle, is thermally stable and insensitive to mechanical impacts. The complex zinc salt of dinitramide was shown herein to exhibit inhibitory activity towards the burning rate of pyrotechnic compositions

Synthesis of Nitro- and Acetyl Derivatives of 3,7,10-Trioxo-2,4,6,8,9,11-hexaaza[3.3.3]propellane

Here, we report the study results of the nitration of 3,7,10-trioxo-2,4,6,8,9,11-hexaaza[3.3.3]propellane (THAP) by different nitrating agents such as nitric acid, mixed nitric/sulfuric acids, nitric anhydride, and mixed concentrated nitric acid/acetic anhydride to furnish 3,7,10-trioxo-2-nitro-2,4,6,8,9,11-hexaaza[3.3.3]propellane and 3,7,10-trioxo-2,8-dinitro-2,4,6,8,9,11-hexaaza[3.3.3]propellane, whereas a lactam–lactim rearrangement was found to take place upon vigorous cooling to give 10-hydroxy-2,4,6,8,9,11-hexaazatricyclo[3.3.3.01,5]undec-9-ene-3,7-dione. The two competing reactions, lactam–lactim rearrangement, and nitration were found to take place. The acylation of 3,7,10-trioxo-2,4,6,8,9,11-hexaaza[3.3.3]propellane was examined and the formation conditions of 2,6-di- and 2,6,9-triacetyl-substituted and 3,7,10-trioxo-2,4,6,8,9,11-hexaacetyl-2,4,6,8,9,11-hexaaza[3.3.3]propellane were established. The acetyl derivatives were found to be instable in an acidic medium and to undergo deacylation. The obtained findings correlate well with the quantum-chemical calculations

CCDC 1539571: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

CCDC 1539570: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

CCDC 1539572: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

CCDC 1539569: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures