711 research outputs found
Journal of general virology – introduction to ‘ICTV virus taxonomy profiles’
No abstract available
Rethinking Inductive Biases for Surface Normal Estimation
Despite the growing demand for accurate surface normal estimation models,
existing methods use general-purpose dense prediction models, adopting the same
inductive biases as other tasks. In this paper, we discuss the inductive biases
needed for surface normal estimation and propose to (1) utilize the per-pixel
ray direction and (2) encode the relationship between neighboring surface
normals by learning their relative rotation. The proposed method can generate
crisp - yet, piecewise smooth - predictions for challenging in-the-wild images
of arbitrary resolution and aspect ratio. Compared to a recent ViT-based
state-of-the-art model, our method shows a stronger generalization ability,
despite being trained on an orders of magnitude smaller dataset. The code is
available at https://github.com/baegwangbin/DSINE.Comment: CVPR 2024 (camera-ready version will be uploaded in March 2024
FutureMapping 2: Gaussian Belief Propagation for Spatial AI
We argue the case for Gaussian Belief Propagation (GBP) as a strong
algorithmic framework for the distributed, generic and incremental
probabilistic estimation we need in Spatial AI as we aim at high performance
smart robots and devices which operate within the constraints of real products.
Processor hardware is changing rapidly, and GBP has the right character to take
advantage of highly distributed processing and storage while estimating global
quantities, as well as great flexibility. We present a detailed tutorial on
GBP, relating to the standard factor graph formulation used in robotics and
computer vision, and give several simulation examples with code which
demonstrate its properties
Identification of an essential virulence gene of cyprinid herpesvirus 3
The genus Cyprinivirus consists of a growing list of phylogenetically related viruses, some of which cause severe economic losses to the aquaculture industry. The archetypal member, cyprinid herpesvirus 3 (CyHV-3) causes mass mortalities worldwide in koi and common carp. A CyHV-3 mutant was described previously that is attenuated in vivo by a deletion affecting two genes (ORF56 and ORF57). The relative contributions of ORF56 and ORF57 to the safety and efficacy profile of this vaccine candidate have now been assessed by analysing viruses individually deleted for ORF56 or ORF57. Inoculation of these viruses into carp demonstrated that the absence of ORF56 did not affect virulence, whereas the absence of ORF57 led to an attenuation comparable to, though slightly less than, that of the doubly deleted virus. To demonstrate further the role of ORF57 as a key virulence factor, a mutant retaining the ORF57 region but unable to express the ORF57 protein was produced by inserting multiple in-frame stop codons into the coding region. Analysis of this virus in vivo revealed a safety and efficacy profile comparable to that of the doubly deleted virus. These findings show that ORF57 encodes an essential CyHV-3 virulence factor. They also indicate that ORF57 orthologues in other cypriniviruses may offer promising targets for the rational design of attenuated recombinant vaccines
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