Integrating crime prevention into urban design and planning

Purpose: This paper aims to understand the delivery of Crime Prevention Through Environmental Design (CPTED) across Europe—from European-wide procedures, through national schemes to effective local strategies. Methodology: The findings come from a review of published literature and reports, case studies and site visits conducted primarily during COST Action TU1203 (2013–16). Findings: Innovative approaches and methods to integrate crime prevention into urban design, planning and management have been generated by multi-agency partnerships and collaborations at European, national and city levels. Methods and procedures developed by the European Committee for Standardization (CEN) Working Group on “Crime Prevention through Urban Planning and Building Design” are pioneering. However, findings show that implementation is best achieved at a local level using methods and procedures tailored to the specific context. Practical and research implications: In-depth research is required to appreciate subtle differences between local approaches and conceptual models developed to better understand approaches and methods. In addition, practitioners and academics working to prevent crime benefit from participation in focused, multi-agency collaborations that, importantly, facilitate visits to urban developments, discussions with local stakeholders responsible for delivery ‘on the ground’ and structured and sustained exploration of innovations and challenges. Originality / value: The authors hope that this paper will contribute to developing a new direction for CPTED practice and research that builds on significant progress in creating safer environments over previous decades

2D FT-ICR MS of Calmodulin : a top-down and bottom-up approach

Two-dimensional Fourier transform ion cyclotron resonance mass spectrometry (2D FT-ICR MS) allows data-independent fragmentation of all ions in a sample and correlation of fragment ions to their precursors through the modulation of precursor ion cyclotron radii prior to fragmentation. Previous results show that implementation of 2D FT-ICR MS with infrared multi-photon dissociation (IRMPD) and electron capture dissociation (ECD) has turned this method into a useful analytical tool. In this work, IRMPD tandem mass spectrometry of calmodulin (CaM) has been performed both in one-dimensional and two-dimensional FT-ICR MS using a top-down and bottom-up approach. 2D IRMPD FT-ICR MS is used to achieve extensive inter-residue bond cleavage and assignment for CaM, using its unique features for fragment identification in a less time- and sample-consuming experiment than doing the same thing using sequential MS/MS experiments

Encoding a magic state with beyond break-even fidelity

We distill magic states to complete a universal set of fault-tolerant logic gates that is needed for large-scale quantum computing. By encoding better quality input states for our distillation procedure, we can reduce the considerable resource cost of producing magic states. We demonstrate an error-suppressed encoding scheme for a two-qubit input magic state, that we call the CZ state, on an array of superconducting qubits. Using a complete set of projective logical Pauli measurements, that are also tolerant to a single circuit error, we propose a circuit that demonstrates a magic state prepared with infidelity $(1.87 \pm 0.16) \times 10^{-2}$. Additionally, the yield of our scheme increases with the use of adaptive circuit elements that are conditioned in real time on mid-circuit measurement outcomes. We find our results are consistent with variations of the experiment, including where we use only post-selection in place of adaptive circuits, and where we interrogate our output state using quantum state tomography on the data qubits of the code. Remarkably, the error-suppressed preparation experiment demonstrates a fidelity exceeding that of the preparation of the same unencoded magic-state on any single pair of physical qubits on the same device.Comment: 10 pages, 7 figures, comments welcom

Investigating the cost-effectiveness of videotelephone based support for newly diagnosed paediatric oncology patients and their families: design of a randomised controlled trial

BACKGROUND: Providing ongoing family centred support is an integral part of childhood cancer care. For families living in regional and remote areas, opportunities to receive specialist support are limited by the availability of health care professionals and accessibility, which is often reduced due to distance, time, cost and transport. The primary aim of this work is to investigate the cost-effectiveness of videotelephony to support regional and remote families returning home for the first time with a child newly diagnosed with cancer METHODS/DESIGN: We will recruit 162 paediatric oncology patients and their families to a single centre randomised controlled trial. Patients from regional and remote areas, classified by Accessibility/Remoteness Index of Australia (ARIA+) greater than 0.2, will be randomised to a videotelephone support intervention or a usual support control group. Metropolitan families (ARIA+ ≤ 0.2) will be recruited as an additional usual support control group. Families allocated to the videotelephone support intervention will have access to usual support plus education, communication, counselling and monitoring with specialist multidisciplinary team members via a videotelephone service for a 12-week period following first discharge home. Families in the usual support control group will receive standard care i.e., specialist multidisciplinary team members provide support either face-to-face during inpatient stays, outpatient clinic visits or home visits, or via telephone for families who live far away from the hospital. The primary outcome measure is parental health related quality of life as measured using the Medical Outcome Survey (MOS) Short Form SF-12 measured at baseline, 4 weeks, 8 weeks and 12 weeks. The secondary outcome measures are: parental informational and emotional support; parental perceived stress, parent reported patient quality of life and parent reported sibling quality of life, parental satisfaction with care, cost of providing improved support, health care utilisation and financial burden for families. DISCUSSION: This investigation will establish the feasibility, acceptability and cost-effectiveness of using videotelephony to improve the clinical and psychosocial support provided to regional and remote paediatric oncology patients and their families

Systemic Therapy in Men With Metastatic Castration-Resistant Prostate Cancer: American Society of Clinical Oncology and Cancer Care Ontario Clinical Practice Guideline

To provide treatment recommendations for men with metastatic castration-resistant prostate cancer (CRPC)