5 research outputs found
Erfaringsopsamling af vandforsyningers lĂŚring i relation til Dokumenteret Drikkevandssikkerhed, monitering ogforureningssituationer:Fra kontrol til styring â risikovurdering i vandforsyningen
Agents intervening against delirium in the intensive care unit (AID-ICU) - Protocol for a randomised placebo-controlled trial of haloperidol in patients with delirium in the ICU
Background
Delirium among patients in the intensive care unit (ICU) is a common condition associated with increased morbidity and mortality. Haloperidol is the most frequently used pharmacologic intervention, but its use is not supported by firm evidence. Therefore, we are conducting Agents Intervening against Delirium in the Intensive Care Unit (AIDâICU) trial to assess the benefits and harms of haloperidol for the treatment of ICUâacquired delirium.
Methods
AIDâICU is an investigatorâinitiated, pragmatic, international, randomised, blinded, parallelâgroup, trial allocating adult ICU patients with manifest delirium 1:1 to haloperidol or placebo. Trial participants will receive intravenous 2.5 mg haloperidol three times daily or matching placebo (isotonic saline 0.9%) if they are delirious. If needed, a maximum of 20 mg/daily haloperidol/placebo is given. An escape protocol, not including haloperidol, is part of the trial protocol. The primary outcome is days alive out of the hospital within 90 days postârandomisation. Secondary outcomes are number of days without delirium or coma, serious adverse reactions to haloperidol, usage of escape medication, number of days alive without mechanical ventilation; mortality, healthârelated qualityâofâlife and cognitive function at 1âyear followâup. A sample size of 1000 patients is required to detect a 7âday improvement or worsening of the mean days alive out of the hospital, type 1 error risk of 5% and power 90%.
Perspective
The AIDâICU trial is based on gold standard methodology applied to a large sample of clinically representative patients and will provide pivotal highâquality data on the benefits and harms of haloperidol for the treatment ICUâacquired delirium
Early Holocene sea-level changes in Ăresund, southern Scandinavia
The Baltic Sea and Kattegat are connected via three straits: StorebĂŚlt, LillebĂŚlt and Ăresund (Fig. 1). Ăresund is the shallowest with a threshold around 7 m deep and increasing water depths to the north (Fig. 2). In the early Holocene, global sea-level rise led to reflooding of Ăresund. It started in northern Ăresund which was transformed into a fjord. However, so far the timing of the transgression has not been well determined, but sediment cores collected north of the threshold, at water depths of 12 to 20 m, and a new series of radiocarbon ages help to constrain this. As the relative sea level continued to rise, the threshold in Ăresund was also flooded, and Ăresund became a strait. In mid-Holocene time, the relative sea level rose until it was 4â5 m higher than at present, and low-lying areas around Ăresund became small fjords. During the late Holocene, the relative sea level fell again. Part of the data set discussed here was presented by Andreasen (2005)