Polyamines and Physical Activity in Musculoskeletal Diseases: A Potential Therapeutic Challenge

Autophagy dysregulation is commonplace in the pathogenesis of several invalidating diseases, such as musculoskeletal diseases. Polyamines, as spermidine and spermine, are small aliphatic cations essential for cell growth and differentiation, with multiple antioxidant, anti-inflammatory, and anti-apoptotic effects. Remarkably, they are emerging as natural autophagy regulators with strong anti-aging effects. Polyamine levels were significantly altered in the skeletal muscles of aged animals. Therefore, supplementation of spermine and spermidine may be important to prevent or treat muscle atrophy. Recent in vitro and in vivo experimental studies indicate that spermidine reverses dysfunctional autophagy and stimulates mitophagy in muscles and heart, preventing senescence. Physical exercise, as polyamines, regulates skeletal muscle mass inducing proper autophagy and mitophagy. This narrative review focuses on the latest evidence regarding the efficacy of polyamines and exercise as autophagy inducers, alone or coupled, in alleviating sarcopenia and aging-dependent musculoskeletal diseases. A comprehensive description of overall autophagic steps in muscle, polyamine metabolic pathways, and effects of the role of autophagy inducers played by both polyamines and exercise has been presented. Although literature shows few data in regard to this controversial topic, interesting effects on muscle atrophy in murine models have emerged when the two “autophagy-inducers” were combined. We hope these findings, with caution, can encourage researchers to continue investigating in this direction. In particular, if these novel insights could be confirmed in further in vivo and clinical studies, and the two synergic treatments could be optimized in terms of dose and duration, then polyamine supplementation and physical exercise might have a clinical potential in sarcopenia, and more importantly, implications for a healthy lifestyle in the elderly population

Lifestyle of Italian University Students Attending Different Degree Courses: A Survey on Physical Activity, Sleep and Eating Behaviors during the COVID-19 Pandemic

The current study aimed to evaluate the Italian university students’ lifestyle during the COVID-19 pandemic, considering the degree courses, chronotype, and sex. Five-hundred thirty-three participants (21.46 ± 0.18 yrs, 335 females) filled out: Godin-Shephard Leisure Time Physical Activity Questionnaire (GSL-TPAQ), Pittsburgh Sleep Quality Index (PSQI), Mediterranean Diet Quality Index (KIDMED), Reduced Morningness-Eveningness Questionnaire (rMEQ) to assess physical activity, sleep, nutrition and chronotype. Use of electronic devices, smoking, and drinking habits were also evaluated. Sports science students were more active (60.92 ± 2.96), slept better (4.40 ± 0.15), showed greater Mediterranean diet adherence (5.98 ± 0.31), and smoked less (smokers: 14.5%) than nursing students (GSL-TPAQ: 38.62 ± 2.92, PSQI: 5.29 ± 0.18, KIDMED: 4.23 ± 0.33, smokers: 27.9%). They displayed a higher percentage of beer drinkers (40% vs. 28.7%) and lower use of electronic devices (5.92 ± 0.17 vs. 9.07 ± 1.17). Evening-type students showed worse sleep (5.96 ± 0.30) and lower Mediterranean diet adherence (4.32 ± 0.52) than Neither- (PSQI: 4.58 ± 0.13, KIDMED: 5.13 ± 0.28) and Morning-types (PSQI: 4.33 ± 0.33, KIDMED: 6.71 ± 0.64). Evening-types also showed a higher percentage of smokers (29.9%) and drinkers (beer: 53.3%, wine: 45.8%, alcohol: 40.2%) than Neither- (smokers: 20.3%, beer: 31.4%, wine: 31.4%, alcohol: 23.5%) and Morning-types (smokers: 8.9%, beer: 19.6%, wine: 19.6%, alcohol: 8.9%). Evening-type males used electronic devices longer (9.10 ± 3.05) than females (6.71 ± 0.41). Females showed fewer drinkers (beer: 26.6%, wine: 29.6%) than males (beer: 49.0%, wine: 38.9%). Maintaining a correct lifestyle even in this unusual condition is essential, in particular among the Evening-type students