Geogebra móvil, para un aprendizaje significativo crítico del perímetro y el área de figuras planas y regiones sombreadas en el grado séptimo de la institución educativa El Limonar

La aproximación al éxito del maestro en el siglo XXI, gira en torno a las suficientes y fundamentadas competencias sobre qué enseña, cómo lo enseña y qué medios utiliza para lograr que el estudiante aprenda de manera comprensiva. En concordancia con estos tres aspectos, la enseñanza de las matemáticas y en especial del pensamiento geométrico, debe ir de la mano de las diversas formas como el estudiante ha asumido su proceso de formación y de cómo el docente presente de manera atractiva las competencias que permitan un aprendizaje significativo crítico de los estudiantes. De ahí que, el papel de las nuevas tecnologías, juega un papel preponderante en las nuevas interrelaciones de docentes y estudiantes que los llevarían a lograr un aprendizaje para la comprensión de los componentes geométricos, en relación al área y perímetro de figuras planas y sombreadas.Abstract: The approach to teacher success in the 21st century revolves around sufficient and well-founded competencies in what it teaches, how it teaches and what means it uses to achieve comprehensively and to represent in a certain way for the student useful learning. In accordance with these three aspects, the teaching of mathematics and especially of geometric thinking must go hand in hand with the various ways in which the student has taken up his training process and how the teacher presents in an attractive way the skills. Hence, the role of new technologies plays a preponderant role in the new interrelations of teachers and students that would lead them to achieve learning for the understanding of the geometric components, in relation to the area and perimeter of flat and shaded figures

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children