393 research outputs found

    Surface plasmon-longitudinal optical phonon contribution to the reflectivity of n-type InSb

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    The reflectivity of n-type InSb has been measured in the far infrared. The doping of the samples was such that the free-carrier plasma frequency was near the longitudinal optical phonon frequency. The results suggest that samples with a sufficiently thick damage layer show effects due to surface plasmons. The results also indicate that the surface plasma excitations are coupled to the phonons. A simple model of this coupling is presented which agrees qualitatively with the observed reflectivity. A somewhat more rigorous theory of the coupling is also presented --Abstract, page ii

    Long-term intravenous infusion of antiarrhythmic drugs using a totally implanted drug delivery system

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    In vitro and in vivo testing was performed to establish the feasibility of a totally implantable pump system to deliver antiarrhythmic agents. In vitro flow characteristics suggested predictable day to day delivery with acceptably small variations in flow with changes in reservoir volume or temperature. During 3 months of in vitro testing, procainamide and bretylium were found suitable for long-term delivery. Delivery of lidocaine was limited by high viscosity and corrosion of steel elements within the pump. The pump was implanted in a subcutaneous pocket in four dogs. Procainamide (0.5 g/ml), delivered at 4 ml/day (70 mg/kg body weight per day), provided a mean steady state drug concentration of 5.3 [mu]g/ml. Bretylium (50 mg/ml), delivered at 8 ml/day (13 mg/kg per day), provided a steady state concentration of 0.8 [mu]g/ml (range 0.4 to 1.4). Long-term intravenous administration of therapeutic doses of bretylium and procainamide with this delivery system has been demonstrated in dogs and appears to be feasible in human subjects.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23974/1/0000223.pd
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