Scenario planning including ecosystem services for a coastal region in South Australia

Coastal regions provide vital ecosystem services for the human well-being. Rapid economic growth and increasing population in coastal regions is exerting more pressure on coastal environments. Here we develop four plausible scenarios to the year 2050 that address above issues in the northern Adelaide coastline, South Australia. Four scenarios were named after their characteristics, Lacuna, Gold Coast SA, Down to Earth, and Green & Gold. Lacuna and Gold Coast SA. Economy declined significantly in Lacuna, whereas, there is highest annual GDP growth (3.5%) in Gold Coast SA, which was closely followed by Green & Gold scenario (3%), GDP under Down to Earth grows at moderate 1.5%. There is highest population growth in Gold Coast SA followed by Green & Gold, Down to Earth and Lacuna. Gold Coast SA scenario led to high inequality as estimated by the Gini co-efficient of 0.45 compared to the current value of 0.33. Ecosystem services declined rapidly under Green & Gold and Lacuna as compared to the other two scenarios. The combination of scenario planning and ecosystem services valuation provides the capacity to guide coastal planning by illustrating enhanced social, environmental and economic benefits. © 2018 Elsevier B.V. **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Harpinder Sandhu” is provided in this record*

‘Mobile phones and the internet, mate’ : (Social) media, art, and revolution in Omar Robert Hamilton’s The City Always Wins

In Omar Robert Hamilton’s novel about the Arab Spring The City Always Wins (2017), readers observe that the phone charger has become as much of an essential as water to the protestors. Although the alternative media possess mass engagement, a global reach, and threaten power, over the course of his novel Hamilton traces the crushing of ‘Twitter revolution’ and the rise of a disillusionment and despair among the revolutionaries. This downward trajectory is typified both in the appellative journey from Hamilton’s non-profit media collective Mosireen – ‘those who insist’ – to the novel’s similar group, portentously named Chaos; and in the text’s tripartite reverse-chronological structure of ‘Tomorrow’, ‘Today’, and ‘Yesterday’. Hamilton’s cousin, the blogger and revolutionary activist Alaa Abd el Fattah, was arrested in March 2013 and sentenced to five years in jail in October 2014 for his role in protests. This detention on trumped-up charges inspired the hashtag #FreeAlaa and multimedia campaigns for his release, but the young man may now face a sentence extended by six months to three years due to his Facebook activity early on in the Egyptian revolution. Hamilton dedicates The City Always Wins to Alaa, writing that it ‘would have been a better book if I’d been able to talk to you’. Meanwhile, the author uses Twitter as an archive of an alternative, resistant history of revolutionary struggle; he embeds Tweets in the fabric of this experimental novel; and social media posts interrupt and punctuate the narrative as in the real life of these millennials. In this paper I explore the novel’s representations of (social) media and the impact these have both on everyday lives and modes of protest. Despite promising beginnings, the internet ultimately turns ‘toxic’ and is depicted as a Pandora’s box of dis- and misinformation, conspiracy theories, fake news, and the manipulations of state media mukhabarat. A more lasting alternative to media may be ‘creative insurgency’ (Kraidy 2016: 206−207). As such, I conclude this article by discussing what art can achieve that (citizen) journalism cannot, and how this applies to the novel’s portrayals of art, particularly music

Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania

Gamma-glutamylcysteine synthetase encoded by GSH1 is the rate-limiting enzyme in the biosynthesis of glutathione and trypanothione in Leishmania. Attempts to generate GSH1 null mutants by gene disruption failed in Leishmania infantum. Removal of even a single allele invariably led to the generation of an extra copy of GSH1, maintaining two intact wild-type alleles. In the second and even third round of inactivation, the markers integrated at the homologous locus but always preserved two intact copies of GSH1. We probed into the mechanism of GSH1 duplication. GSH1 is subtelomeric on chromosome 18 and Southern blot analysis indicated that a 10-kb fragment flanked by 466-bp direct repeated sequences was duplicated in tandem on the same chromosomal allele each time GSH1 was targeted. Polymerase chain reaction analysis and sequencing confirmed the generation of novel junctions created at the level of the 466-bp repeats consequent to locus duplication. In loss of heterozygosity attempts, the same repeated sequences were utilized for generating extrachromosomal circular amplicons. Our results are consistent with break-induced replication as a mechanism for the generation of this regional polyploidy to compensate for the inactivation of an essential gene. This chromosomal repeat expansion through repeated sequences could be implicated in locus duplication in Leishmania

No recent adaptive selection on the apyrase of Mediterranean Phlebotomus: implications for using salivary peptides to vaccinate against canine leishmaniasis

Vaccine development is informed by a knowledge of genetic variation among antigen alleles, especially the distribution of positive and balancing selection in populations and species. A combined approach using population genetic and phylogenetic methods to detect selective signatures can therefore be informative for identifying vaccine candidates. Parasitic Leishmania species cause the disease leishmaniasis in humans and mammalian reservoir hosts after inoculation by female phlebotomine sandflies. Like other arthropod vectors of disease agents, sandflies use salivary peptides to counteract host haemostatic and immunomodulatory responses during bloodfeeding, and these peptides are vaccine candidates because they can protect against Leishmania infection. We detected no contemporary adaptive selection on one salivary peptide, apyrase, in 20 populations of Phlebotomus ariasi, a European vector of Leishmania infantum. Maximum likelihood branch models on a gene phylogeny showed apyrase to be a single copy in P. ariasi but an ancient duplication event associated with temporary positive selection was observed in its sister group, which contains most Mediterranean vectors of L. infantum. The absence of contemporary adaptive selection on the apyrase of P. ariasi may result from this sandfly's opportunistic feeding behaviour. Our study illustrates how the molecular population genetics of arthropods can help investigate the potential of salivary peptides for disease control and for understanding geographical variation in vector competence

Going to sleep in the supine position is a modifiable risk factor for late pregnancy stillbirth; findings from the New Zealand multicentre stillbirth case-control study

Objective: Our objective was to test the primary hypothesis that maternal non-left, in particular supine going-to-sleep position, would be a risk factor for late stillbirth (≥28 weeks of gestation). Methods: A multicentre case-control study was conducted in seven New Zealand health regions, between February 2012 and December 2015. Cases (n=164) were women with singleton pregnancies and late stillbirth, without congenital abnormality. Controls (n=569) were women with on-going singleton pregnancies, randomly selected and frequency matched for health region and gestation. The primary outcome was adjusted odds of late stillbirth associated with self-reported going-to-sleep position, on the last night. The last night was the night before the late stillbirth was thought to have occurred or the night before interview for controls. Going to- sleep position on the last night was categorised as: supine, left-side, right-side, propped or restless. Multivariable logistic regression adjusted for known confounders. Results: Supine going-to-sleep position on the last night was associated with increased late stillbirth risk (adjusted odds ratios (aOR) 3.67, 95% confidence interval (CI) 1.74 to 7.78) with a population attributable risk of 9.4%. Other independent risk factors for late stillbirth (aOR, 95% CI) were: BMI (1.04, 1.01 to 1.08) per unit, maternal age ≥40 (2.88, 1.31 to 6.32), birthweight <10th customised centile (2.76, 1.59 to 4.80), and <6 hours sleep on the last night (1.81, 1.14 to 2.88). The risk associated with supine-going-to sleep position was greater for term (aOR 10.26, 3.00 to 35.04) than preterm stillbirths (aOR 3.12, 0.97 to 10.05). Conclusions: Supine going-to-sleep position is associated with a 3.7 fold increase in overall late stillbirth risk, independent of other common risk factors. A public health campaign encouraging women not to go-to-sleep supine in the third trimester has potential to reduce late stillbirth by approximately 9%

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy