Emergence of enterovirus 71 C4a in Denmark, 2009 to 2013

Enterovirus (EV) 71 has emerged as a primary cause of severe neurologic enterovirus infection in the aftermath of the global polio eradication effort. Eleven subgenotypes of EV71 exist, the C4 subgenotype being associated with large outbreaks in Asia with high mortality rates. This subgenotype has rarely been reported in Europe. In the period between 1 January 2009 and 31 December 2013 a total of 1,447 EV positive samples from 1,143 individuals were sent to the Statens Serum Institute (SSI), and 938 samples from 913 patients were genotyped at the Danish National World Health Organization Reference laboratory for Poliovirus at SSI. Echovirus 6 (E06) (n=141 patients), echovirus 30 (E30) (n=114), coxsackievirus A6 (CA06) (n=96) and EV71 (n=63) were the most prevalent genotypes. We observed a shift in circulating EV71 subgenotypes during the study period, with subgenotype C4 dominating in 2012. A total of 34 EV71 patients were found to be infected with strains of the C4 subgenotype, and phylogenetic analysis revealed that they belonged to the C4a lineage. In our study, the proportions of cases with cerebral and/or sepsis-like symptoms were similar in those affected by C4a (19/34) and those with C1 and C2 (15/35). The majority (n=30) of the 34 EV71 C4 cases were children ≤5 years of age, and males (n=22) were over-represented. Continued EV surveillance is required to monitor the spread of EV71 C4 in Denmark and the rest of Europe. </jats:p

Enhanced photoenergy harvesting and extreme Thomson effect in hydrodynamic electronic systems

The thermoelectric (TE) properties of a material are dramatically altered when electron-electron interactions become the dominant scattering mechanism. In the degenerate hydrodynamic regime, the thermal conductivity is reduced and becomes a {\it decreasing} function of the electronic temperature, due to a violation of the Wiedemann-Franz (WF) law. We here show how this peculiar temperature dependence gives rise to new striking TE phenomena. These include an 80-fold increase in TE efficiency compared to the WF regime, dramatic qualitative changes in the steady state temperature profile, and an anomalously large Thomson effect. In graphene, which we pay special attention to here, these effects are further amplified due to a doubling of the thermopower.Comment: 6 pages, 3 figure

The DiskMass Survey. X. Radio synthesis imaging of spiral galaxies

We present results from 21 cm radio synthesis imaging of 28 spiral galaxies from the DiskMass Survey obtained with the VLA, WSRT, and GMRT facilities. We detail the observations and data reduction procedures and present a brief analysis of the radio data. We construct 21 cm continuum images, global HI emission-line profiles, column-density maps, velocity fields, and position-velocity diagrams. From these we determine star formation rates (SFRs), HI line widths, total HI masses, rotation curves, and azimuthally-averaged radial HI column-density profiles. All galaxies have an HI disk that extends beyond the readily observable stellar disk, with an average ratio and scatter of R_{HI}/R_{25}=1.35+/-0.22, and a majority of the galaxies appear to have a warped HI disk. A tight correlation exists between total HI mass and HI diameter, with the largest disks having a slightly lower average column density. Galaxies with relatively large HI disks tend to exhibit an enhanced stellar velocity dispersion at larger radii, suggesting the influence of the gas disk on the stellar dynamics in the outer regions of disk galaxies. We find a striking similarity among the radial HI surface density profiles, where the average, normalized radial profile of the late-type spirals is described surprisingly well with a Gaussian profile. These results can be used to estimate HI surface density profiles in galaxies that only have a total HI flux measurement. We compare our 21 cm radio continuum luminosities with 60 micron luminosities from IRAS observations for a subsample of 15 galaxies and find that these follow a tight radio-infrared relation, with a hint of a deviation from this relation at low luminosities. We also find a strong correlation between the average SFR surface density and the K-band surface brightness of the stellar disk.Comment: 22 pages + Appendix, 16 figures + Atlas, 5 tables. Accepted for publication in Astronomy & Astrophysic

The DiskMass Survey. VIII. On the Relationship Between Disk Stability and Star Formation

We study the relationship between the stability level of late-type galaxy disks and their star-formation activity using integral-field gaseous and stellar kinematic data. Specifically, we compare the two-component (gas+stars) stability parameter from Romeo & Wiegert (Q_RW), incorporating stellar kinematic data for the first time, and the star-formation rate estimated from 21cm continuum emission. We determine the stability level of each disk probabilistically using a Bayesian analysis of our data and a simple dynamical model. Our method incorporates the shape of the stellar velocity ellipsoid (SVE) and yields robust SVE measurements for over 90% of our sample. Averaging over this subsample, we find a meridional shape of sigma_z/sigma_R = 0.51^{+0.36}_{-0.25} for the SVE and, at 1.5 disk scale lengths, a stability parameter of Q_RW = 2.0 +/- 0.9. We also find that the disk-averaged star-formation-rate surface density (Sigma-dot_e,*) is correlated with the disk-averaged gas and stellar mass surface densities (Sigma_e,g and Sigma_e,*) and anti-correlated with Q_RW. We show that an anti-correlation between Sigma-dot_e,* and Q_RW can be predicted using empirical scaling relations, such that this outcome is consistent with well-established statistical properties of star-forming galaxies. Interestingly, Sigma-dot_e,* is not correlated with the gas-only or star-only Toomre parameters, demonstrating the merit of calculating a multi-component stability parameter when comparing to star-formation activity. Finally, our results are consistent with the Ostriker et al. model of self-regulated star-formation, which predicts Sigma-dot_e,*/Sigma_e,g/sqrt(Sigma_e,*). Based on this and other theoretical expectations, we discuss the possibility of a physical link between disk stability level and star-formation rate in light of our empirical results.Comment: Accepted for publication in ApJ. 15 pages, 6 figures, 2 tables. An electronic version of Table 1 is available by request, or at http://www.astro.rug.nl/~westfall/research/dmVIII_table1.tx

Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends

SummaryMechanistic target of rapamycin (mTOR) regulates cell growth, metabolism and aging in response to nutrients, cellular energy stage and growth factors. mTOR is frequently up-regulated in cancer including hepatocellular carcinoma (HCC) and is associated with bad prognosis, poorly differentiated tumors, and earlier recurrence. Blocking mTOR with rapamycin and first generation mTOR inhibitors, called rapalogs, has shown promising reduction of HCC tumor growth in preclinical models. Currently, rapamycin/rapalogs are used in several clinical trials for the treatment of advanced HCC, and as adjuvant therapy in HCC patients after liver transplantation and TACE. A second generation of mTOR pathway inhibitors has been developed recently and is being tested in various clinical trials of solid cancers, and has been used in preclinical HCC models. The results of series of clinical trials using mTOR inhibitors in HCC treatment will emerge in the near future