190 research outputs found
Kinetics of diffuesion-controlled oxygen ordering in a lattic-gas model of YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7</sub><sub>-</sub>δ
Assessment of passive ankle stiffness:A new device allowing for a variable center of rotation
Impact of HPV-associated p16-expression on radiotherapy outcome in advanced oropharynx and non-oropharynx cancer
AbstractBackground and purposeHPV is found in head and neck cancer from all sites with a higher prevalence in oropharynx cancer (OPC) compared to non-OPC. HPV/p16-status has a significant impact on radiotherapy (RT) outcome in advanced OPC, but less is known about the influence in non-OPC. We analyzed HPV-associated p16-expression in a cohort of patients with stage III–IV pharynx and larynx cancer treated with primary, curatively intended (chemo-)RT, aiming to test the hypothesis that the impact of HPV/p16 also extends to tumors of non-oropharyngeal origin.Material and methods1294 patients enrolled in previously conducted DAHANCA-trials between 1992 and 2012 were identified. Tumors were evaluated by p16-immunohistochemistry and classified as positive in case of staining in >70% of tumors cells.ResultsThirty-eight percent (490/1294) of the tumors were p16-positive with a significantly higher frequency in OPC (425/815) than in non-OPC (65/479), p<.0001. In OPC p16-positivity significantly improved loco-regional control (LRC) (adjusted HR [95% CI]: 0.43 [0.32–0.57]), event-free survival (EFS) (HR 0.44 [0.35–0.56]), and overall survival (OS) (HR: 0.38 [0.29–0.49]), respectively, compared with p16-negativity. In non-OPC no prognostic impact of p16-status was found for either endpoint: LRC (HR: 1.13 [0.75–1.70]), EFS (HR: 1.06 [0.76–1.47]), and OS (HR: 0.82 [0.59–1.16]).ConclusionsThe independent influence of HPV-associated p16-expression in advanced OPC treated with primary RT was confirmed. However, RT-outcome in the group of non-OPC did not differ by tumor p16-status, indicating that the prognostic impact may be restricted to OPC only
New model for surface fracture induced by dynamical stress
We introduce a model where an isotropic, dynamically-imposed stress induces
fracture in a thin film. Using molecular dynamics simulations, we study how the
integrated fragment distribution function depends on the rate of change and
magnitude of the imposed stress, as well as on temperature. A mean-field
argument shows that the system becomes unstable for a critical value of the
stress. We find a striking invariance of the distribution of fragments for
fixed ratio of temperature and rate of change of the stress; the interval over
which this invariance holds is determined by the force fluctuations at the
critical value of the stress.Comment: Revtex, 4 pages, 4 figures available upon reques
Pinning of a solid--liquid--vapour interface by stripes of obstacles
We use a macroscopic Hamiltonian approach to study the pinning of a
solid--liquid--vapour contact line on an array of equidistant stripes of
obstacles perpendicular to the liquid. We propose an estimate of the density of
pinning stripes for which collective pinning of the contact line happens. This
estimate is shown to be in good agreement with Langevin equation simulation of
the macroscopic Hamiltonian. Finally we introduce a 2--dimensional mean field
theory which for small strength of the pinning stripes and for small capillary
length gives an excellent description of the averaged height of the contact
line.Comment: Plain tex, 12 pages, 3 figures available upon reques
Tri-critical behavior in rupture induced by disorder
We discover a qualitatively new behavior for systems where the load transfer
has limiting stress amplification as in real fiber composites. We find that the
disorder is a relevant field leading to tri--criticality, separating a
first-order regime where rupture occurs without significant precursors from a
second-order regime where the macroscopic elastic coefficient exhibit power law
behavior. Our results are based on analytical analysis of fiber bundle models
and numerical simulations of a two-dimensional tensorial spring-block system in
which stick-slip motion and fracture compete.Comment: Revtex, 10 pages, 4 figures available upon reques
Asteroseismology of the Hyades red giant and planet host epsilon Tauri
Asteroseismic analysis of solar-like stars allows us to determine physical
parameters such as stellar mass, with a higher precision compared to most other
methods. Even in a well-studied cluster such as the Hyades, the masses of the
red giant stars are not well known, and previous mass estimates are based on
model calculations (isochrones). The four known red giants in the Hyades are
assumed to be clump (core-helium-burning) stars based on their positions in
colour-magnitude diagrams, however asteroseismology offers an opportunity to
test this assumption. Using asteroseismic techniques combined with other
methods, we aim to derive physical parameters and the evolutionary stage for
the planet hosting star epsilon Tau, which is one of the four red giants
located in the Hyades. We analysed time-series data from both ground and space
to perform the asteroseismic analysis. By combining high signal-to-noise (S/N)
radial-velocity data from the ground-based SONG network with continuous
space-based data from the revised Kepler mission K2, we derive and characterize
27 individual oscillation modes for epsilon Tau, along with global oscillation
parameters such as the large frequency separation and the ratio between the
amplitude of the oscillations measured in radial velocity and intensity as a
function of frequency. The latter has been measured previously for only two
stars, the Sun and Procyon. Combining the seismic analysis with interferometric
and spectroscopic measurements, we derive physical parameters for epsilon Tau,
and discuss its evolutionary status.Comment: 13 pages, 13 figures, 4 tables, accepted for publication in Astronomy
& Astrophysic
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