41 research outputs found

    XRCC1 Deficiency Sensitizes Human Lung Epithelial Cells to Genotoxicity by Crocidolite Asbestos and Libby Amphibole

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    Background: Asbestos induces DNA and chromosomal damage, but the DNA repair pathways protecting human cells against its genotoxicity are largely unknown. Polymorphisms in XRCC1 have been associated with altered susceptibility to asbestos-related diseases. However, it is unclear whether oxidative DNA damage repaired by XRCC1 contributes to asbestos-induced chromosomal damage

    Chromium in Drinking Water: Sources, Metabolism, and Cancer Risks

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    Regulation of DNA damage responses by mismatch repair

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    Importance of Chromium−DNA Adducts in Mutagenicity and Toxicity of Chromium(VI)

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