Results of Fetal Ultrasound Imaging and Doppler Ultrasound Study in Pregnant Women with Extragenital Pathology

The aim of this research was to study the parameters of fetal ultrasound imaging and Doppler ultrasound study in pregnant women with extragenital diseases (EGDs) during the treatment regimes with and without hyperbaric oxygen therapy (HBOT). Materials and Methods: A total of 235 pregnant women were examined prospectively at 5 to 40 weeks of gestation. The main group included 191 women with EGDs (anemia, arterial hypertension, chronic pyelonephritis); the control group included 44 women with physiological pregnancy without EGDs. Evaluation of treatment efficacy was based on data from clinical and laboratory findings before treatment and after its completion. The following hardware methods of research were performed: ultrasonography, fetometry, dopplerometric study of fetoplacental complex. Results: Based on data obtained from this study, the following findings were made: - In the early stages of gestation, there were no disturbances in fetoplacental blood circulation. - Starting the 19th week of pregnancy, there is a significant increase in the uterine artery resistive index in pregnant women with arterial hypertension. - In women with a high perinatal risk on the background of the studied EGDs, the third trimester of pregnancy, despite the ongoing conventional treatment, is characterized by persistent impairment in fetoplacental blood circulation. - The inclusion of HBOT in complex therapy in the early stages of pregnancy in women with a high perinatal risk allows leveling out the inevitable disturbances in fetoplacental blood circulation on the background of the studied EGDs

Controlled Structure of Polyester/Hydroxyapatite Microparticles Fabricated via Pickering Emulsion Approach

Biodegradable polyester/hydroxyapatite microparticles are widely proposed as microcarriers for drug/cell delivery or scaffolds for bone tissue regeneration. The current research implements the surfactant-free approach for the fabrication of polyester-based microparticles filled with hydroxyapatite nanoparticles (nHA) via the oil/water Pickering emulsion solvent evaporation technique for the first time, to the best of our knowledge. The process of polyester microparticle fabrication using nHA for the oil/water interface stabilization was studied as a function of phase used for nHA addition, which allows the preparation of a range of microparticles either filled with nHA or having it as a shell over the polymeric core. The effect of processing conditions (polymer nature, polymer/nHA ratio, ultrasound treatment) on particles’ total yield, size distribution, surface and volume morphology, and chemical structure was analyzed using SEM, EDX, Raman spectroscopy, and mapping. Addition of nHA either within the aqueous or oil phase allowed the effective stabilization of the oil/water interface without additional molecular surfactants, giving rise to hybrid microparticles in which total yield, size distribution, and surface morphology depended on all studied processing conditions. Preliminary ultrasound treatment of any phase before the emulsification process led to a complex effect but did not affect the homogeneity of nHA distribution within the polymeric core of the hybrid microparticles

Results of Fetal Ultrasound Imaging and Doppler Ultrasound Study Depending on the Factors of Perinatal Risk in Preterm Birth

Premature birth (PB) is associated with placental insufficiency, which is confirmed in the morphological study of the placenta. Ultrasonic markers of placental abnormalities, often preceding PB, have been identified: changes in placental structure, premature ripening of the placenta, oligohydramnios, and fetal-placental circulation