Fatores de risco para o diagnóstico da síndrome metabólica em adolescentes sobrepesos, obesos e superobesos

Determinar para uma população de adolescentes matriculados na condição de casos novos no Ambulatório de Medicina do Adolescente da Faculdade de Medicina de Botucatu/UNESP de ambos os gêneros, na faixa etária compreendida entre 10 anos completos e 16 anos incompletos, considerados sobrepesos, obesos e superobesos, quais deles apresentavam critérios para a SM e dentre os critérios avaliados quais eram os mais prevalentes. 200 adolescentes de ambos os gêneros, compreendidos na faixa etária entre 10 anos completos e 16 anos incompletos foram submetidos à avaliação antropométrica, sendo obtidos peso, estatura, circunferência abdominal e calculado o Índice de Massa Corporal (IMC), classificado de acordo com a idade e o sexo e os respectivos pontos de corte propostos pelo Centers for Desease Control and Prevention (CDC, 2002) e classificados em eutróficos, sobrepesos, obesos e superobesos. A aferição da pressão arterial foi criteriosamente obtida segundo as recomendações. Aqueles considerados com o IMC igual ou superior ao 85o percentil para o IMC foram submetidos a avaliação laboratorial, com dosagem de Colesterol Total e Frações, Triglicérides, Insulinemia de jejum, Glicemia de jejum, Tiroxinemia livre (T4 livre) e Hormônio Tireoestimulante (TSH), para avaliar a presença dos critérios para SM propostos por Zimmet e col.,2007,ou excluí-los pela presença de alguma outra alteração clínica ou metabólica, que pudesse estar relacionada a outra doença. A Insulinemia de jejum e a Glicemia de jejum foram também utilizadas para determinar a presença de provável resistência à insulina. Calculou-se HOMA-IR, Quicki e Fração Glicemia de jejum/Insulinemia de jejum (FGI). Dos 200 adolescentes avaliados 69 (34,5%), foram considerados sobrepesos, 77(38,5%) obesos e 54 (27%) superobesos; 41(20,5%) apresentaram diagnóstico de SM pelos critérios utilizados e dentre aqueles...To determine which individuals showed criteria for MS and, among the investigated criteria, which were the most prevalent in a population of adolescents registered in the condition of new cases at the Adolescents’ Medicine Outpatient Unit of the Botucatu School of Medicine/UNESP, of both genders, at the age range from 10 years old (complete) to 16 years old (incomplete), considered to be overweight, obese and super-obese, Two hundred adolescents of both genders, at the age range from 10 years old (complete) to 16 years old (incomplete), were submitted to anthropometric evaluation, and the following measurements were taken: weight, height and abdominal circumference. The Body Mass Index (BMI) was estimated and classified according to age and gender and the respective cutoff points proposed by the Centers for Disease Control and Prevention (CDC, 2002). The participants were then classified as eutrophic, overweight, obese and super-obese. Arterial pressure was carefully measured according to recommendations. Those considered to have BMI equal to or higher than the 85o percentile for BMI were submitted to laboratory evaluation by testing for Total Cholesterol and Fractions, Triglycerides, Fasting Insulinemia, Fasting Glycemia, Free Thyroxinemia (free T4) and Thyroid-stimulating Hormone (TSH) in order to evaluate the presence of the criteria for MS proposed by Zimmet et al, 2007 or exclude them by the presence of a clinical or metabolic alteration that could be related to another disease. Fasting insulinemia and fasting glycemia were also used to determine the presence of probable insulin resistance. HOMA-IR, Quicki and fasting Glycemia fraction/fasting insulinemia (FGI) were calculated. Of the 200 adolescents evaluated 69 (34,5%) were considered to be overweight, 77(38.5%) obese and 54 (27%) super-obese; 41(20.5%) were diagnosed with MS by the criteria used and, among those analyzed... (Complete abstract click electronic access below)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36

Abstract Obesity in adolescents has reached epidemic proportions and is associated with the inflammatory response and viral infections. The aim of this study was to understand the profile of inflammatory cytokines and chemokines associated with the inflammatory response and metabolic syndrome (MetS) in obese adolescents with positive serology for adenovirus 36 (ADV36). Thirty-six overweight, 36 obese, and 25 severe obesity adolescents aged 10 to 16 years were included in the study. The following variables were analyzed: sex, age, body mass index (BMI), blood pressure, total cholesterol and fractions, triglycerides, glucose, serum cytokine concentrations, and ADV36 antibodies. Cytokines and chemokines were quantified by cytometry and ADV36 serology was determined by enzyme-linked immunosorbent assay (ELISA). The results showed higher levels of the cytokines interleukin-1beta (IL-1β), IL-6, IL-10 and of the chemokine interferon-gamma-inducible protein 10 (IP-10) in severe obesity adolescents compared to the obese and overweight groups, as well as in the group with MetS compared to the group without this syndrome. The frequency of ADV36-positive individuals did not differ between groups. The findings revealed differences in BMI between the obese and severe obesity groups versus the overweight group in the presence of positivity for ADV36, suggesting an association with weight gain and possibly MetS installation