Network Building Capabilities for a Sustainable and Circular Economy

This research introduces a novel integrated model that affiliates the innovative capacity of circular start-ups, as seen through their network-building capabilities, with the influential attribute of top management support as outlined in the T-O-E theory. The investigation employs a quantitative research methodology based on a random sampling technique for the entire research population. The structural equation model, utilizing SMARTPLS, is used on a dataset comprising 231 manufacturing-based circular start-ups and their franchises in India. The findings reveal significant direct and indirect relationships between network-building capabilities and the innovation function of circular start-ups. The study highlights the pivotal role of top management support, following the T-O-E framework, as a complete mediator between network-building capabilities and organizational innovativeness. This inquiry establishes that effective networking and other factors confer a competitive edge upon firms. Furthermore, it contributes to the literature on the circular economy within emerging markets, offering insights applicable across various sectors like IT, hospitality, aviation, pharmaceuticals, and more. The study's implications extend to future researchers and policymakers, advocating for adopting a multi-level perspective to foster and ensure the innovativeness of circular start-ups in diverse industries

Cutaneous metastasis of transitional cell carcinoma of the urinary bladder: Cytological aspect

Cutaneous metastasis from transitional cell carcinoma urinary bladder is a rare clinical entity associated with poor prognosis. This case report describes a 51-year-old male who presented with multiple cutaneous metastases arising from high grade transitional cell carcinoma bladder with lamina propria invasion. The prominent cytological features include medium sized to large pleomorphic cells with irregular nuclear outlines, coarse chromatin pattern, and tumor giant cells. An awareness of this rare clinical entity and high index of suspicion is needed for diagnosis

Novel non-glycerol-based cytofectins with lactic acid-derived head groups

We report herein the design, synthesis, and transfection biology of a novel series of non-glycerol-based cationic lipids with lactic acid-derived head groups The synthetic procedure adopted herein for preparing 1-hydroxy-prop-2-yl head-group-based monocationic transfection lipids 1-7 is fairly straightforward and potentially applicable in designing other cationic lipids with lactic acid-derived head groups. A striking anchor-length dependency was observed in NIH3T3 cells in the sense that except lipid 4, all the other lipids were essentially transfection-inefficient. Ethidium bromide assay for the lipid:DNA interactions is consistent with the general observation that significant lipid:DNA interactions do not guarantee on improved transfection efficiency cationic lipid mediated gene delivery. Given its remarkable transfection properties and low cellular toxicity, lipid 4 is likely to find future use in the area of liposomal gene delivery