Pemberdayaan Masyarakat dalam Upaya Pencegahan Penularan COVID-19 melalui Peningkatan Pemahaman dan Keterampilan Pembuatan Sabun Cuci Tangan Bunga Rosella pada Siswa Pesantren Di Gresik Sebagai Implementasi SDGs 3: Community Empowerment in Efforts to Prevent Transmission of COVID-19 through Increasing Understanding and Skills in Making Rosella Flower Hand Washing Soap for Islamic Boarding School Students in Gresik as Implementation of SDGs 3

Efforts to inhibit the transmission of COVID-19 are continuing to this day. One of them is using hand-washing soap to prevent the transmission of this virus. The Faculty of Pharmacy, Airlangga University, seeks to implement SDGs-3 through community service activities to increase community empowerment, especially for the younger generation. The utilization of natural ingredients containing many active compounds has yet to be discovered. The solution is to provide information on the source of the active ingredients for hand washing soap, for example, the Rosella flower, explaining the mechanism of soap in inhibiting the spread of viruses and how to make hand washing soap. The activity was carried out in Gresik with counseling and training methods. The outcome was an increase in participants' understanding, as indicated by an average post-test score of >65, with an increase in score of >10% compared to the pretest. In addition, one product of Rosela flower hand washing soap was also obtained. From this activity, it was concluded that there was an increase in understanding of 28%. It is hoped that this increase in understanding and skills for the younger generation can mobilize the surrounding community so that prevention of the transmission of COVID-19 is more massive and conditions of good health and well-being in society will be achieved.

Synthesis, anti-angiogenic activity and prediction toxicity of (E)-3-(3-methoxyphenyl) propenoic acid

Background: Anti-angiogenic medications, one of cancer chemo preventive mechanism were permitted for different cancers. Nevertheless, major primary and secondary resistance obstruct efficacy in several tumor types. Moreover, the improvement of safe and effective NSAIDs for angiogenesis inhibition is complicated, because of their serious toxicity. So, we require improving clinically appropriate strategies to boost efficacy of anti-angiogenic drugs with low risk of toxicity. Objectives: The present study aimed to synthesize the (E)-3- (3-methoxyphenyl)propenoic acid (3MPCA), to determine the anti-angiogenic activity and predict its toxicity. Methods: 3MPCA was obtained by Knoevenagel reaction using microwave irradiation at 400 Watt. The anti-angiogenesis experimental was performed using chorioallantois membrane of embryonated chicken eggs induced by b-FGF. The potency of 3MPCA was verified at dosage 30 and 60 ng and compared with celecoxib 60 ng. Toxicity prediction of 3MPCA was performed by ProTox II online program. Results: The results showed that 3MPCA was achieved in good yield (89%). Anti angogenic activity was showed by endothelial cells growth in neovascular capillaries of new blood vessel of chorioallantois membrane of embryonated chicken eggs. The endothelial cells growth decreased until 41.7-83%. The prediction LD50 was 1772mg/kg. Conclusion: (E)-3-(3-methoxyphenyl)propenoic acid can be obtained through Knovenagel reaction using microwave irradiation and it has potential as anti-angiogenesis inhibitor with low toxicity