Differential induction of total IgE by two Salmonella enterica serotypes

The main goal of this study was to establish how the inflammation caused by infection with two different Salmonella enterica serotypes, S. Typhimurium and S. Enteritidis, may lead to the predisposition to allergy as measured by total IgE level in the blood. Infection by S. Typhimurium did not affect the systemic IgE concentration while in S. Enteritidis-infected patients there was a significant 3.5-fold increase. This effect was especially profound in patients >4 years old, with up to the eight-fold increase above the norm. The degree of dysbiosis in these two infections measured with the comparative counts of cultivated bacteria showed an inverse relationship with the IgE concentration. Earlier we reported the elevated level of IL-17 in patients infected by S. Enteritidis. In the current study a significant correlation was found between the concentrations of IL-17 and IgE suggesting a possible role played by this cytokine in triggering the production of IgE in response to S. Enteritidis infection

The Problem of Adaptation of the Diaspora Armenians in Transition Armenia

Isolation, Adaptation, Integration, Democratization, J17,

Employee responses to CEO activism

We examine employee responses to CEO activism, the increasingly common practice of CEOs taking public stances on socio-political issues. CEO activism may bolster employees' identification with their organizations and strengthen shared beliefs among employees. Alternatively, CEO activism may alienate employees if CEO stances contrast with employees' ideologies. We find that employee satisfaction is higher when CEOs engage in activism that is aligned with employees’ ideologies. Furthermore, firms with CEO activism experience a net inflow of productive, ideologically-aligned inventors, which contributes to increased firm-level innovation. The improvements in employee satisfaction and innovation constitute an important channel that connects aligned CEO activism to increased firm value.24 month embargo; first published 10 May 2024This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Evaluating the burden of brucellosis in hospitalized patients in Armenia, 2016

ObjectiveTo understand the disease burden, we studied the epidemiological and clinical characteristics and associated costs for brucellosis patients hospitalized in Nork hospital in 2016.IntroductionBrucellosis, endemic in Armenia, is recognized as a significant public health challenge with a major economic burden. To address the regional threat of brucellosis for both animal health and public health, the “One Health Surveillance of Brucellosis in Armenia” was initiated in December 2016. The project aims to develop scientifically sound strategies and policies for sustainable control of the disease.MethodsIn 2016, 265 patients diagnosed with brucellosis were hospitalized at “Nork” hospital, of whom 16 were 0-14 years old and 94% were males. Diagnosis was confirmed using agglutination test and ELISA. The SPSS program was used to analyze the data.ResultsDistribution of the disease by marz revealed that the most cases came from Ararat (53), followed by Kotayk (49), Armavir (38), Aragatsotn (36), Yerevan (28), Gegharkunik (26), Vayots Dzor (24), Syunik (8), and Lori (3). Clinical data indicated that 71% of patients had acute brucellosis with fever, arthralgia and night sweating while 29% suffered chronic brucellosis with damage of organ systems. The primary complaints included arthralgia (80%), sweating (60%) and fever (40%). Joint pain was mainly located in knee, elbow, and sacroiliac regions. Average grade of fever was 37,9±0,95oC. Total days spent in hospital were 1798, economic losses for the hospital were estimated at AMD 36 million per year.ConclusionsThose at the highest risk for brucellosis were males living in Ararat and Kotayk marzes who work with livestock.

Potential Involvement of Salmonella Infection in Autoimmunity

In this work, we investigated the potential effects of nontyphoidal Salmonella infection on autoantibody (AA) formation. The titer and profiles of autoantibodies in the sera of patients with acute salmonellosis due to Salmonella enterica serovar Typhimurium (S. Typhimurium) or Salmonella enterica serovar Enteritidis (S. Enteritidis) infection, as well as in convalescent patients, were determined with indirect immunofluorescence. A significant increase of autoantibodies in acute diseases caused by both serotypes of Salmonella and during post infection by S. Enteritidis was detected. Antibody profile analysis by multivariate statistics revealed that this increase was non-specific and was not dependent on the infectious agent or disease stage. The results obtained suggest that nontyphoidal Salmonella infection contributes to the generation of autoantibodies and may play a role in autoimmune disease